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Biological diagnosis marker for central nervous system demyelinating diseases

A technology for demyelinating diseases and diagnostic markers, which is applied in the field of biological diagnostic markers for demyelinating diseases of the central nervous system, and can solve problems such as unclear changes

Inactive Publication Date: 2015-06-10
GENERAL HOSPITAL OF PLA
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Problems solved by technology

[0008] However, up to now, the changes of PDGF, CXCL12, and CXCL14 in ON are still unclear. Therefore, detecting the changes of PDGF, CXCL12, and CXCL14 in the cerebrospinal fluid of ON patients may find new biological markers for diagnosis and prognosis, and Potential to further reveal the physiological mechanisms underlying optic neuritis onset and recovery

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  • Biological diagnosis marker for central nervous system demyelinating diseases
  • Biological diagnosis marker for central nervous system demyelinating diseases
  • Biological diagnosis marker for central nervous system demyelinating diseases

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Embodiment 1

[0020] 1 experiment

[0021] 1.1 Research object

[0022] A total of 55 patients from the Neuro-Ophthalmology Department of PLA General Hospital from September 2012 to September 2013 were selected. Among them, 35 patients with ON (taking 4 weeks after the onset as the node, divided into 18 patients in the acute phase group and 17 patients in the stable phase group), and 10 patients with NMO as the experimental group. ON met the diagnostic criteria for optic neuritis proposed by the ONTT research group of the United States. NMO met the diagnostic criteria proposed by Wingerchuk et al. Ten patients with CVST (Cerebral venous sinus thrombosis, intracranial venous sinus thrombosis) were selected as the control group, who were matched with the ON and NMO groups in gender and age. All subjects were ≥16 years old, had no history of hormone, immunosuppressant or immunomodulator treatment for at least 3 months, and excluded infectious optic neuritis and other eye diseases and system...

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Abstract

The invention discloses a biological diagnosis marker for central nervous system demyelinating diseases. The biological diagnosis marker refers to platelet-derived growth factors, chemotactic factors 12 and chemotactic factors 14 in cerebrospinal fluid. The central nervous system demyelinating diseases include optic neuritis (ON) and neuromyelitis optica (NMO); disease changes can be evaluated by monitoring the platelet-derived growth factor and the chemotactic factors in cerebrospinal fluid in different phases of the optic neuritis ON so as to judge recovering conditions. A new biological marker can be discovered by detecting levels and changes of platelet-derived growth factors, chemotactic factors 12 and chemotactic factors 14 in cerebrospinal fluids of ON and NMO patients, so that the medullar sheath regeneration capability can be estimated, an experimental basis is provided for the ON and NMO recovery and development, and a new idea is provided for treatment.

Description

technical field [0001] The invention relates to the medical field, in particular to a biodiagnostic marker for central nervous system demyelinating diseases. Background technique [0002] The optic nerve belongs to the central nervous system, and its nerve fibers are wrapped by a myelin sheath composed of oligodendrocytes. Apoptosis of oligodendrocytes often causes ON (Optic neuritis, optic neuritis), which is an inflammatory demyelinating disease that involves the optic nerve and leads to axonal damage. [0003] ON is a type of CIS (Clinically isolated syndrome, clinically isolated syndrome), clinically, CIS patients can progress to MS (Multiple sclerosis, multiple sclerosis) or NMO (Neuromyelitis optica, neuromyelitis optica) and other CNS (Central nervous system, central nervous system) demyelinating disease. In demyelinating diseases, there is not only loss of myelin in the CNS, but also axonal damage. As far as MS and NMO are concerned, the pathological damage of NMO ...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6893G01N2800/285
Inventor 魏世辉陈霆隽李朝辉
Owner GENERAL HOSPITAL OF PLA
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