3 results about "Platlet-Derived Growth Factor" patented technology

This invention discloses a topical preparation of recombinant platelet-derived growth factor (PDGF) and its preparation method. In this invention, each milliliter of the topical preparation contains the following components and dosages: 40,000-85,000 IU of PDGF, 50-200 mg of polyvinyl alcohol, 10-100 mg of arginine hydrochloride, 54-60 mg of sodium chloride, 40-80 mg of disodium hydrogen phosphate, 0.5-2.5 mg of sodium dihydrogen phosphate, and 0.5-5 mg of benzalkonium chloride, diluted to 10 ml with water for injection. The pH of the solution is 7.0. The PDGF topical solution of this invention has optimized compatibility of its raw materials, exhibits good stability, and can promote wound healing effectively and rapidly, shortening wound healing time and improving wound healing efficiency, thus demonstrating good therapeutic efficacy.

The present disclosure provides methods for treating delayed union or nonunion fractures in a bone More specifically, the present disclosure provides methods of inducing bone formation in a delayed union or nonunion fracture in a bone comprising: applying to a site of delayed union or nonunion fracture a composition comprising a platelet-derived growth factor (PDGF) solution disposed in a biocompatible matrix.