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Drug/factor control-released thin film scaffold and preparation method thereof

A technology of factors and drugs, which is applied in the field of drug/factor controlled-release film scaffolds and its preparation, can solve the problems of not being able to guide the proliferation of seed cells, and achieve the effect of improving hydrophilicity and promoting adhesion

Inactive Publication Date: 2017-03-15
上海市口腔病防治院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing scaffold materials that guide periodontal tissue regeneration, some promote osteogenesis by slow release of cytokines, but cannot guide the proliferation of seed cells

Method used

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  • Drug/factor control-released thin film scaffold and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Step 1, using electrospinning technology to prepare SMV / Col-I / PCL film-like biomimetic scaffold material.

[0055] With reference to the proportion of Col-I contained in the periodontal ligament of normal people, take Col-I and PCL as main raw materials and add an appropriate amount of SMV, wherein, the amount of SMV added is 15% (or 1%, 5%) of the mass of Col-I , 10%; 25% and other different additions), others are PCL; after mixing the above materials, add chloroform (or without any organic solvent), and stir on a magnetic stirrer until the solution is colorless, transparent and viscous Shaped spinning solution, the mass concentration of the solution is 6% (or 15%, 20%, 35%; 45% and other different concentrations).

[0056] Control the flow rate of the electrospinning flow rate of the injection pump at (0.01-0.02ml / min), adjust the voltage of the electrospinning high-voltage generator within the range of (5-15KV), control the space temperature at 30-35°C, and the humid...

Embodiment 2

[0062] Step 1, using electrospinning technology to prepare SMV / Col-I / PCL film-like biomimetic scaffold material.

[0063] Use Col-I and PCL as the main raw materials and add an appropriate amount of SMV, wherein the mass ratio of Col-I and PCL is 1:1 (or 1:0.01; 1:0.1; 1:0.5; 1:2; 1:5 ; 1:10; 1:100 and other different ratios), the addition of SMV is 25% of the total mass of Col-I and PCL (or 1%, 5%, 10%; 35%; 55% and other different additions) After mixing, add acetone (or do not use any organic solvent) and place on a magnetic stirrer and stir until the solution is a colorless, transparent and viscous spinning solution, and the mass percentage concentration of the solute sum in this solution is 11% (or 5 %, 20%, 35%; 45% and other different concentrations).

[0064] Control the flow rate of the electrospinning flow rate of the injection pump at (0.01-0.02ml / min), adjust the voltage of the electrospinning high-voltage generator within the range of (5-15KV), control the space ...

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Abstract

The invention provides a drug / factor control-released thin film scaffold. The drug / factor control-released thin film scaffold is characterized by comprising a film-like bionic scaffold, a PDGF (Platelet Derived Growth Factor) coating layer and a slow release layer which are sequentially arranged. According to a scaffold material, i.e, a film-like scaffold material on the surface layer of a factor / the core layer of a drug, for clinic periodontal treatment, provided by the invention, controlled release of active factors and drugs is realized, and cell proliferation and osteogenic differentiation are promoted, so that three elements of seed cells, a scaffold material and regulatory factors in tissue regeneration are organically combined, periodontal repairing is promoted, and a facilitation function for periodontal tissue engineering research is obtained.

Description

technical field [0001] The invention relates to the technical field of biological tissue engineering scaffolds, in particular to a drug / factor controlled-release film scaffold and a preparation method thereof. Background technique [0002] Chronic periodontitis can lead to gingival inflammation, periodontal tissue destruction, alveolar bone loss, and even tooth loss. It is one of the most important factors causing tooth loss in healthy people. According to the figures released by the third national oral epidemiological survey in 2005, the total prevalence rate of gum and periodontal disease in 35-44 years old was 97.2%, while that of 67-74 years old was as high as 99.4%. [0003] Periodontal disease is not only the primary cause of tooth loss in adults, but also an important factor affecting the functions of important organs such as the heart, lungs, and kidneys. According to foreign research reports, the probability of coronary heart disease and stroke in patients with per...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/24A61L27/18A61L27/16A61L27/20A61L27/22A61L27/54A61L27/58
CPCA61L27/16A61L27/18A61L27/20A61L27/227A61L27/24A61L27/54A61L27/58A61L2300/216A61L2300/252A61L2300/412A61L2300/604A61L2420/06A61L2420/08C08L67/04C08L5/08C08L5/04C08L25/18C08L39/00
Inventor 赵丙姣刘月华
Owner 上海市口腔病防治院
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