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Bifunctional novel periodontal guided tissue regeneration membrane with sandwich structure and preparation method thereof and application

A periodontal tissue regeneration, dual-function technology, applied in tissue regeneration, medical science, prosthesis, etc., can solve the problems of lack of inducibility of periodontal soft tissue, failure of regeneration and repair process, etc., to promote tissue differentiation and healing, promote blood vessels the formation, good biocompatibility and degradability of

Inactive Publication Date: 2017-12-12
STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the periodontal tissue regeneration-guided membranes in the prior art, such as GTR film materials, are mainly aimed at periodontal hard tissues, and lack induction to periodontal soft tissues.
The regeneration of periodontal tissue includes not only the hard tissue composed of alveolar bone and cementum, but also soft tissues such as periodontal ligament and gingiva. If the periodontal tissue cannot be completely repaired, the entire regeneration process may fail.
However, there are few reports on periodontal regeneration membranes for soft tissue restoration

Method used

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  • Bifunctional novel periodontal guided tissue regeneration membrane with sandwich structure and preparation method thereof and application
  • Bifunctional novel periodontal guided tissue regeneration membrane with sandwich structure and preparation method thereof and application
  • Bifunctional novel periodontal guided tissue regeneration membrane with sandwich structure and preparation method thereof and application

Examples

Experimental program
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Effect test

Embodiment 1

[0042]A membrane for guiding periodontal tissue regeneration, in which the inner layer is polycaprolactone / silk fibroin / mesoporous bioactive glass microsphere fiber membrane, and the mesoporous bioactive glass microsphere has a radial fiber pore structure with a molar composition of 80 %SiO 2 -20%CaO, the mass fraction is 0.4%, the particle size is 200~500nm; the middle layer is polycaprolactone / silk fibroin fiber membrane, and polycaprolactone / silk fibroin is dissolved in hexafluoroisopropanol The total mass concentration of silk fibroin is 6%, and the mass ratio of silk fibroin to polycaprolactone is 1:3; the outer layer is polycaprolactone / silk fibroin fiber membrane loaded with platelet-derived growth factor, and the platelet-derived growth factor is in the outer layer The mass concentration in the silk spinning solution is 50ng / mL.

[0043] The preparation method is as follows:

[0044] S1: Dissolve the freeze-dried silk fibroin powder and polycaprolactone in the hexafl...

Embodiment 2

[0052] In the guided periodontal tissue regeneration film provided in this example, the molar composition of the mesoporous bioactive glass microspheres is 60% SiO 2 -40%CaO, the mass fraction is 0.6%, and the particle size is 200~500nm; the content of platelet-derived growth factor is 80ng / mL; the polycaprolactone / silk fibroin in the middle layer is dissolved in hexafluoroisopropanol The total mass concentration is 8%, and the mass ratio of silk fibroin to polycaprolactone is 1:3; other components and amounts are consistent with those in Example 1.

[0053] S1~S3 in the preparation method is consistent with embodiment 1, and S4 is as follows:

[0054] Electrospin the outer layer, middle layer and inner layer spinning solution in turn by electrospinning method: put the outer layer spinning solution into the syringe, fix the syringe on the micro-sampler, and the needle at the front end of the syringe (inner diameter 1mm) As an anode, the surface of the drum receiving device wa...

Embodiment 3

[0056] In the guided periodontal tissue regeneration membrane provided in this example, the molar composition of mesoporous bioactive glass microspheres is 90% SiO 2 -10%CaO, the mass fraction is 0.8%, the particle size is 200~500nm; the content of platelet-derived growth factor is 100ng / mL; the polycaprolactone / silk fibroin in the middle layer is dissolved in hexafluoroisopropanol The total mass concentration is 7%, and the mass ratio of silk fibroin to polycaprolactone is 1:3; other components and amounts are consistent with those in Example 1.

[0057] S1~S3 in the preparation method is consistent with embodiment 1, and S4 is as follows:

[0058] Electrospin the outer layer, middle layer and inner layer spinning solution in turn by electrospinning method: put the outer layer spinning solution into the syringe, fix the syringe on the micro-sampler, and the needle at the front end of the syringe (inner diameter 1mm) As an anode, the surface of the drum receiving device was w...

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Abstract

The invention relates to a bifunctional novel periodontal guided tissue regeneration membrane with a sandwich structure and a preparation method thereof and application. The bifunctional novel periodontal guided tissue regeneration membrane comprises an inner layer, an intermediate layer and an outer layer. The inner layer is a polycaprolactone / silk fibroin / mesoporous bioactive glass microsphere fiber membrane; the intermediate layer is a polycaprolactone / silk fibroin fiber membrane; and the outer layer is a polycaprolactone / silk fibroin fiber membrane loading platelet-derived growth factors. The bifunctional novel periodontal guided tissue regeneration membrane is of a three-layer-membrane structure and can promote periodontal soft tissue regeneration and have functions of periodontal hard tissue and soft tissue dual regeneration and repair; the bifunctional novel periodontal guided tissue regeneration membrane can also effectively prevent the invasion of gingival epithelial cells to a bone defect area and provide a space for regeneration and reconstruction of bone tissues. In addition, the periodontal guided tissue regeneration membrane also has good biocompatibility, biodegradability and biological activity.

Description

technical field [0001] The invention belongs to the field of medical biomaterials, and more specifically relates to a dual-functional novel "sandwich" structure guiding periodontal tissue regeneration membrane and its preparation method and application. Background technique [0002] Periodontal disease is one of the common and frequently-occurring diseases in oral diseases. According to statistics, nearly 90% of the world's people have different degrees of periodontal disease (mainly periodontitis and gingivitis). If it is not treated in time, it will cause The loss of connective tissue and bone tissue, which eventually leads to the loosening and loss of teeth, is the number one cause of tooth loss in adults. Therefore, prevention and treatment of periodontal disease is particularly important to human health. Traditional treatment methods mainly include tooth extraction, dentures and root canal treatment. Tooth extraction causes destructive injuries to patients; dentures a...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/54A61L27/10A61L27/22A61L27/18A61L27/50
CPCA61L27/10A61L27/18A61L27/227A61L27/50A61L27/54A61L2300/252A61L2300/414A61L2430/02A61L2430/12A61L2430/34C08L89/00C08L67/04
Inventor 苗国厚杨雪超李正茂赵世勇叶上珠夏娟
Owner STOMATOLOGY AFFILIATED STOMATOLOGY HOSPITAL OF GUANGZHOU MEDICAL UNIV
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