Application of sesquiterpene lactone compound in preparation of drugs for treating optic neuritis
An ester compound, optic neuritis technology, applied in the medical field of autoimmune diseases, can solve the problems of treatment failure, large systemic side effects, hormone tolerance of treatment methods, etc.
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[0025] The molecular formula of the sesquiterpene lactone compound used to prepare the medicine for treating neuromyelitis optica studied in this embodiment is as follows: figure 1 As shown, also known as ACT001, the chemical name of ACT001 is: (3R, 3aS, 9R, 9aS, 9bS)-3-((dimethylamino)methyl)-9-hydroxyl-6,9-dimethyl -3,3a,4,5,7,8,9,9a-octahydroazulene[4,5-b]furan-2(9bH)-one fumarate is a michelactone derivative. Molecular formula such as figure 1 shown. In this example, ACT001 was used to study the treatment of patients with AQP4 autoimmune antibody-positive neuromyelitis optica.
[0026] Pharmacological and drug efficacy experiments are as follows:
[0027] 1. We first conducted an in vitro test on the active ingredients. According to the in vitro test results, ACT001 can inhibit the proliferation of BV-2 cells in vitro, and its IC50 value is 23.6 μM. And it can significantly reduce the release of microglial inflammatory factors (TNF-α, IL-6, NO) activated by LPS at 10 μ...
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