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Human bone substitute material and preparation method thereof

A technology of human bone and implementation method, which is applied in the field of human bone substitute materials and its preparation, can solve the problems of inability to maintain the ability to induce osteogenesis and high immunogenicity of heterogeneous bone, and achieve low price, small human rejection reaction, and wide source of materials Effect

Inactive Publication Date: 2015-06-17
王芳
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  • Summary
  • Abstract
  • Description
  • Claims
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Problems solved by technology

[0003] One of the main purposes of the present invention is to solve the problem that the human body has too high immunogenicity to xenogeneic bone and cannot maintain its ability to induce osteogenesis, and specifically provides a human bone substitute material and its preparation method

Method used

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Examples

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Embodiment

[0020] A human bone substitute material and its preparation method, using pig bone as raw material, extracting non-collagen protein in pig bone through biochemical reaction; Make a mixture, and finally compound to obtain a human bone substitute material. The specific steps are:

[0021] Step 1: Take the raw pork bone, separate the epiphysis from the backbone, remove the soft tissue and bone marrow, and use it as A1;

[0022] Step 2: Carry out the degreasing and decalcifying reactions on the A1 prepared in the step 1, shape it with a mold, and perform the degreasing reaction again to obtain A2;

[0023] Step 3: use CaCl successively for the A2 prepared in the step 2 2 , EDTA-Na 2 Extract the non-collagen protein in the bone with LiCl, freeze-dry it, and make it into strips and granules to obtain B1;

[0024] Step 4: Take the A2 prepared in the step 2, extract the osteogenic protein with urea to obtain an extract, take the extract for water dialysis, take the precipitate, and...

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PUM

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Abstract

For solving the problems of high immunogenicity of human body to heterogeneous bone and maintenance of osteogenic ability, the invention provides a human bone substitute material and a preparation method thereof. According to the invention, pig bone is taken as a raw material, noncollagen proteins in the pig bone can be extracted through a biochemistry reaction; ossification protein in the bone is extracted by using urea, noncollagen proteins and the ossification protein are prepared to a mixing agent, and finally the human bone substitute material is prepared. According to the human bone substitute material and the preparation method thereof, the fracture healing can be effectively promoted and human bone can be successfully substituted, bone grafting is carried out, bone graft operation risk and human body rejection can be obviously reduced, and the human bone substitute material can be used on market.

Description

technical field [0001] The invention relates to the field of orthopedic surgery, in particular to a human bone substitute material and a preparation method thereof. Background technique [0002] At present, there have been researches on human bone substitute materials at home and abroad. At present, the human bone substitute materials include: hydroxyapatite, tricalcium phosphate, active glass ceramics, recombined heterogeneous bone and other decalcified bone matrix materials. Although alternative materials have been put into use in the market, various problems have been discovered as the use progresses: 1. The human body is too immunogenic to xenogeneic bone; 2. The ability to induce osteogenesis is poor; 3. After combining with the human body The rejection reaction is obvious, and the success rate of the operation is low. Therefore, there is an urgent need for a human bone substitute material that solves the high immunogenicity of the human body to xenogeneic bone and mai...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/26
Inventor 王芳胡鹏翟乃亮
Owner 王芳
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