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Traditional Chinese medicine composition for treating depression and preparation method, detection method and application thereof

A composition and technology for depression, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as poor circulation of Qi and blood, depression of patients, etc.

Inactive Publication Date: 2015-08-12
LIANYUNGANG ZHIYUAN PHARMA TECH SERVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

If the qi and blood between the liver and gallbladder are unobstructed, the circulation between the viscera will be unimpeded, but if there is a lesion, the qi and blood circulation between the entire viscera will be blocked, causing depression in the patient

Method used

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  • Traditional Chinese medicine composition for treating depression and preparation method, detection method and application thereof
  • Traditional Chinese medicine composition for treating depression and preparation method, detection method and application thereof
  • Traditional Chinese medicine composition for treating depression and preparation method, detection method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0234] Determination of content: Determination by high performance liquid chromatography:

[0235] (1) Chromatographic conditions: the chromatographic column is C 18 Column, the mobile phase is methanol:water with a ratio of 15:85, and the flow rate is 1.2mL?min -1 , the detection wavelength is 256nm, the column temperature is 25°C, and the number of theoretical plates is not less than 4000 based on the quercetin peak;

[0236] (2) Test product solution: take the content of 10 Chinese medicine composition capsules of the present invention with the difference in filling amount meeting the requirements, grind it finely, dry it at 50°C to constant weight, take 1g, and accurately weigh it; put a plug with a capacity of 20mL Add 80% ethanol to the mark in the bottle, ultrasonicate twice at room temperature, 0.5h each time; shake well, filter, take the subsequent filtrate, adjust to 20mL with 80% ethanol, and use it as the test solution;

[0237] (3) Preparation of reference sub...

Embodiment 2

[0251] Determination of content: Determination by high performance liquid chromatography:

[0252] (1) Chromatographic conditions: the chromatographic column is C 18 Column, the mobile phase is methanol:water with a ratio of 15:85, and the flow rate is 1.2mL?min -1 , the detection wavelength is 256nm, the column temperature is 25°C, and the number of theoretical plates is not less than 4000 based on the quercetin peak;

[0253] (2) Test product solution: take the content of 10 Chinese medicine composition capsules of the present invention with the difference in filling amount meeting the requirements, grind it finely, dry it at 50°C to constant weight, take 1g, and accurately weigh it; put a plug with a capacity of 20mL Add 80% ethanol to the mark in the bottle, ultrasonicate twice at room temperature, 0.5h each time; shake well, filter, take the subsequent filtrate, adjust to 20mL with 80% ethanol, and use it as the test solution;

[0254] (3) Preparation of reference sub...

Embodiment 3

[0268] Determination of content: Determination by high performance liquid chromatography:

[0269] (1) Chromatographic conditions: the chromatographic column is C 18 Column, the mobile phase is methanol:water with a ratio of 15:85, and the flow rate is 1.2mL?min -1 , the detection wavelength is 256nm, the column temperature is 25°C, and the number of theoretical plates is not less than 4000 based on the quercetin peak;

[0270] (2) The test solution: take 10 tablets of the traditional Chinese medicine composition of the present invention with the difference in filling amount meeting the requirements, grind them finely, dry them at 50°C to constant weight, take 1g, and accurately weigh them; put them in a 20mL volumetric flask , add 80% ethanol to the mark, ultrasonicate twice at room temperature, 0.5h / time; shake well, filter, take the subsequent filtrate, adjust to 20mL with 80% ethanol, as the test solution;

[0271] (3) Preparation of reference substance solution: Accur...

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Abstract

The invention belongs to the field of medicine, and provides a traditional Chinese medicine composition for treating depression and a preparation method, a detection method and application thereof. The traditional Chinese medicine composition is prepared from the following raw materials by weight: 1-2 parts of Chenopodium hybridumL., 1-2 parts of large angiopteris rhizome, 1-2 parts of Euonymus sacrosancta Koidz. and 1-2 parts of Polemonium coeruleum. The preparation process is as below: decocting fried Chenopodium hybridumL, large angiopteris rhizome, Euonymus sacrosancta Koidz. and Polemonium coeruleum with water 1-3 times, adding water in the volume 4-15 times, soaking for 0.5-2h, decocting for 0.5-2 h, merging the decoction, filtering, concentrating the filtrate, drying and crushing into a dry powder, adding the accessories, and preparing the powder into tablets, pills, hard capsules, soft capsules and granules by the conventional traditional Chinese pharmaceutical method. The invention also provides a method for determining the content of the traditional Chinese medicine and a fingerprint detection method. The methods have the advantages of high accuracy, stability and repeatability. The traditional Chinese medicine composition can be used for the preparation of a medicament for treating insomnia and amnesia.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicines, and relates to a traditional Chinese medicine composition for treating depression, in particular to a traditional Chinese medicine composition made from Chenopodium japonicus, Chinese horseshoe root, Euonymus cuspidatum and Rhizoma chinensis as raw materials. Background technique [0002] For the treatment of depression, it mainly starts from the patient's state of mind, and treats it from its hobbies and emotional fluctuations. The traditional Chinese medicine has a long-standing understanding of depression, and the treatment of depression in the book "Neijing" has already been It exists, but its disease name has not been defined yet, but it has a relatively clear interpretation of the depression of the five qi, which has laid a corresponding foundation for the treatment of the five qi, and provides a corresponding reference for the treatment of depression today. If the qi and blood ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/37A61P25/00A61P25/20A61P25/24G01N30/02
Inventor 齐乐辉杨大宇韩淼
Owner LIANYUNGANG ZHIYUAN PHARMA TECH SERVICE CO LTD
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