Application of Lunasin polypeptide in aspect of preparing substance with weight-reducing activity

An active substance and aspect technology, which is applied in the application field of Lunasin polypeptide in the preparation of active substances with weight loss, can solve the problems of lack of new activity research, and achieve the effects of reducing accumulation and inhibiting mRNA expression.
CN104840943AInactive Publication Date: 2015-08-19INST OF CROP SCI CHINESE ACAD OF AGRI SCI
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
INST OF CROP SCI CHINESE ACAD OF AGRI SCI
Publication Date
2015-08-19
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses application of Lunasin polypeptide in the aspect of preparing substance with weight-reducing activity. Lunasin is substance with weight-reducing activity and is prepared by inhibiting differentiation of mouse preadipocyte (3T3-L1) through a PPAR gamma passage. The application includes: using an MTT method to detect influence, on 3T3-L1 adipocyte activity, of Lunasin at different dosages; detecting inhibiting effect, on adipocyte differentiation, of Lunasin at different dosages. Compared with current study conditions of Lunasin, the application has the advantages that the application shows that Lunasin can inhibit differentiation of insulin-induced 3T3-L1 cells, reduce accumulation of lipid droplets in lipid and inhibit mRNA expression of PPAR gamma, Lunasin presents dosage dependence, and effect of Lunasin with dosage higher than 50ug / mL is better than that of rosiglitazone of 5ug / mL; the application shows that Lunasin has potential weight-reducing effect.
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Description

technical field

[0001] The present invention relates to the application of new physiologically active substances of Lunasin polypeptides, in particular to the application of Lunasin polypeptides in the preparation of active substances for weight loss, and in particular to the preparation of Lunasin by inhibiting the differentiation of mouse preadipocytes (3T3-L1) through the PPARγ pathway. It has applications in the aspect of weight loss active substances. Background technique

[0002] Lunasin is a polypeptide containing 43 amino acids that was first isolated and identified from soybeans. Animal experiments have shown that Lunasin will not be completely digested and degraded in the gastrointestinal system, but can be completely absorbed by the body. Lunasin is considered to be a brand-new peptide with cancer prevention effect. Lunasin can also reduce the body's serum total cholesterol level and LDL-C, and has a significant lipid-lowering effect. In addition, it has been rep...

Claims

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