Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of mesalamine in preparation of medicament for treating pyoderma gangrenosum

A technology of pyoderma gangrenosum and mesalazine, which is applied in the field of medicine, can solve problems such as prominent adverse reactions, patient resistance to treatment, and difficulty in reducing drugs, and achieve mild adverse reactions, high compliance, and good tolerance Effect

Inactive Publication Date: 2015-09-09
JIANGSU PROVINCE HOSPITAL
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently, there is no specific effective treatment for this disease. The most commonly used treatment option is the application of glucocorticoids, but it usually requires a higher dose than usual, so the adverse reactions are prominent, and some patients are resistant to treatment.
[0003] At present, there is no special and effective treatment plan for pyoderma gangrenosum. The original common treatment method is to use glucocorticoids in excess of the conventional dose, and it needs long-term application. Such as causing high blood pressure, diabetes, osteoporosis, central obesity and inducing and aggravating infection, these adverse reactions themselves are enough to cause death

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0008] The following shows that mesalazine can be used as a drug for treating pyoderma gangrenosum through the specific clinical application of mesalazine in the treatment of pyoderma gangrenosum.

[0009] The used mesalazine (trade name "Edisa", French Aidifa pharmaceutical factory), specification 500mg / bag.

[0010] Patient 1. Male, 80 years old, was admitted to the hospital because of "left lower extremity ulcer with pain for several months". After admission, he was diagnosed with pyoderma gangrenosum based on clinical manifestations and histopathology. He was treated with glucocorticoids and azathioprine successively. Azathioprine, followed by oral administration of mesalamine 4g / d (in four divided doses), the pain relieved after one week, and the ulcer surface shrunk to half of the original area after 3 months, and the dose of mesalazine was reduced to 1.5g / d for maintenance After 4 months of treatment, the ulcer surface shrunk to a quarter of the original area, and the ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses an application of mesalamine in preparation of a medicament for treating pyoderma gangrenosum. When the mesalamine is used for treating the pyoderma gangrenosum, the skin lesion pain of a patient can be relieved within a short term, the symptom is generally relieved within a week, and the skin lesion is continually reduced and can be quickly controlled; and the mesalamine is good in tolerance, high in compliance of patients, few and light in adverse responses and good in overall safety, and can cause light stomach discomfort and hepatic dysfunction which can be restored after withdrawal. The application provides a brand-new choice and thought for treating the pyoderma gangrenosum.

Description

technical field [0001] The invention belongs to the field of medicine, in particular to the application of mesalazine in the preparation of medicine for treating pyoderma gangrenosum. Background technique [0002] Pyoderma gangrenosum (PG) is a chronic recurrent skin ulcer disease, in which neutrophil infiltration in the dermis can be seen histopathologically. The disease has characteristic skin lesions, manifested as latent necrotic ulcers of skin lesions, accompanied by severe pain, which seriously affects the quality of life of patients and may endanger their lives. Currently, there is no specific effective treatment for this disease. Currently, the most commonly used treatment is the application of glucocorticoids, but it usually requires a higher dose than the conventional one. Therefore, its adverse reactions are prominent, and some patients are resistant to treatment. [0003] At present, there is no special and effective treatment plan for pyoderma gangrenosum. The ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/606A61P17/02
Inventor 侯麦花卢新政
Owner JIANGSU PROVINCE HOSPITAL
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com