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Medicine composition for treating dog dermatomycosis and preparation method and application thereof

A technology of dermatophytosis and antifungal drugs, applied to the compound antifungal drug composition and its preparation for the treatment of canine dermatomycosis, and in the field of compound antifungal preparations, which can solve the problem of reducing the infectivity of dermatophytosis and poor treatment effect, etc. problems, to achieve the effect of overcoming easy recurrence, low cost and good curative effect

Inactive Publication Date: 2015-11-11
NORTHEAST AGRICULTURAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Topical antifungal shampoos can be used as an adjunct to the treatment of dermatophytosis, it can reduce the infectivity of dermatophytosis, but the treatment effect is not good when used alone

Method used

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  • Medicine composition for treating dog dermatomycosis and preparation method and application thereof
  • Medicine composition for treating dog dermatomycosis and preparation method and application thereof
  • Medicine composition for treating dog dermatomycosis and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Preparatory Example 1 Drug Extraction (Water Extraction Method)

[0055] Grind the scorpion, kelp and turmeric separately, weigh 100g of the coarse powder, put it in a stainless steel decoction container, add 1000mL of distilled water, soak for 6h, put it on the electric furnace with asbestos net, heat and decoct it for 1h, and use silk cloth to filter to obtain the decoction, add 500mL of distilled water to the filtered medicinal residue, soak, decoct, and filter according to the previous method, combine the filtrate twice, heat and concentrate to a small volume, filter with ultrafiltration membrane, and use a vacuum drying oven Dry under reduced pressure at 70°C for 36 hours to obtain water-extracted powder of Chinese medicinal materials for testing. The water extracts of each traditional Chinese medicine were stored dry at room temperature.

Embodiment 2

[0056] Preparatory Example 2 Drug Extraction (alcohol extraction method)

[0057] Grind the scorpion, kelp and turmeric separately, weigh 100g of the coarse powder, extract 3 times with 60% ethanol under reflux in a water bath at 60°C, each time for 30min, filter the extract and then concentrate it to about 5ml. Ultrafiltration membrane filtration, drying under reduced pressure in a vacuum oven at 70° C. for 36 hours, to obtain alcohol-extracted powder of Chinese medicinal materials for testing. The alcohol extracts of each traditional Chinese medicine were stored dry at room temperature.

[0058] The preparation of embodiment 1 compound antifungal preparation

[0059] Weigh 0.008kg, 0.06kg, and 0.30kg of the water-extracted powders of scorpion, kelp, and turmeric obtained in Preliminary Example 1, respectively, dissolve them in dimethyl sulfoxide, soak for 12h, then add glycerin and 95% ethanol to soak for 12h, and Mix the above-mentioned components evenly, add water to 10L...

Embodiment 3

[0062] The preparation of embodiment 3 compound antifungal preparations

[0063] Weigh 0.012kg, 0.10kg, and 0.50kg of the water-extracted powders of scorpion, kelp, and turmeric obtained in Preliminary Example 1, respectively, dissolve them in dimethyl sulfoxide, soak for 12h, add glycerin and 95% ethanol to soak for 12h, and Mix the above-mentioned components evenly, add water to 10L, stir, and soak for 12 hours, so that the active ingredients of each component are fully dissolved in water, filter, fill into plastic tanks, 100ml per tank, and store away from light.

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Abstract

The invention discloses a medicine composition for treating dog dermatomycosis and a preparation method and application thereof, and belongs to the field of preparation and application of medicine for treating the dog dermatomycosis. The medicine composition for treating the dog dermatomycosis comprises a sorpio extract, a radix curcuma extract and a laminaria extract. The invention further discloses a preparation method of the compound antifungal medicine composition. The preparation method comprises the steps that all the components are weighed by mass, then appropriate auxiliary materials or carriers are added, and the external preparation for livestock is prepared according to a conventional preparation method. The invention further discloses medicine which has the better effect on dog dermatomycosis treatment, and the medicine is composed of a first component and a second component which are independent to each other; the first component comprises the sorpio extract, the radix curcuma extract and the laminaria extract, and the second component adopts itraconazole. The medicine composition for treating the dog dermatomycosis has the advantages of being low in cost, good in safety and treatment effect, small in side effect and the like.

Description

technical field [0001] The invention relates to a compound antifungal preparation for treating dermatophytosis, in particular to a compound antifungal pharmaceutical composition for treating canine dermatophytosis and its preparation method and application, belonging to the field of drug preparation and application for canine dermatophytosis. Background technique [0002] As the most intimate companion animals of human beings, dogs play an important role in today's life. Unreasonable feeding and management of dogs, unscientific and reasonable bathing, unbalanced diet, excessive and long-term use of antibiotics, and urban environmental pollution have caused the incidence of canine dermatophytosis to increase year by year. [0003] Dermatomycosis (surface mycosis) refers to a fungal disease in which fungi infect the epidermis and its appendages. At present, there are more than 1,400 types of fungi that cause human and animal infections, of which there are only dozens of fungi...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61K31/496A61P31/10A61P17/00A61K35/646
Inventor 范宏刚冯国峰张建涛栾莉关伟李蓓刘涛张卓梁新江赵越陈悦
Owner NORTHEAST AGRICULTURAL UNIVERSITY
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