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Gel containing triclosan

A triclosan gel, triclosan technology, applied in medical preparations containing active ingredients, medical preparations with non-active ingredients, peptide/protein ingredients, etc., can solve patients' tingling sensation, dry skin, Problems such as protein denaturation, achieve high clarity, refreshing skin feeling, and increase water solubility

Inactive Publication Date: 2015-12-30
TIANJIN SPRING BIOPHARM LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At 25°C, the solubility of triclosan in water is only 4.6mg / L, and in practical applications, as a bacteriostatic agent, the recommended dosage of triclosan is 0.05%-0.3%, which greatly limits the three Wide Application of Chlorosan in Aqueous Matrix
Ethanol is a commonly used disinfectant, but it has a certain astringency. If it is used as a skin disinfectant for a long time, it will cause dry and tight skin, and the experience is extremely bad; when it is used for wound disinfection, patients will feel tingling, and alcohol will Cause protein denaturation and affect wound healing

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 3

[0037] Example 1 Preparation of Triclosan Nanoemulsion

[0038] Composition content Triclosan 10g Caprylic / Capric Glycerides (Miglyol 812, SASOL) 20g Polyoxyethylene castor oil (Cremophor EL, BASF) 35g water Make up to 700ml

[0039] Add triclosan to caprylic acid / capric glyceride according to the above prescription amount, stir evenly until the system is transparent and clear, then add polyoxyethylene castor oil, continue stirring until transparent and clear, slowly add to the remaining water, stir Until the system is completely emulsified, a triclosan nano-emulsion with clear and transparent appearance and slightly blue opalescence is formed. The average particle diameter of the obtained triclosan nanoemulsion was 15nm as detected by a Mastersizer2000 particle size analyzer.

Embodiment 2 3

[0040] Example 2 Triclosan free hand sanitizer gel

[0041] Composition content Triclosan Nanoemulsion 1g Carbomer 934 0.4g Triethanolamine 0.5g water Make up to 100g

[0042] The preparation method of this triclosan free hand sanitizing gel is as follows:

[0043] 1) Slowly add the prescribed amount of carbomer to 40g of water, and leave it at room temperature for 10 hours to allow the carbomer to fully swell;

[0044] 2) Add the triclosan nanoemulsion and the remaining water to the product of step 1), and stir evenly;

[0045] 3) Under stirring conditions, slowly add triethanolamine dropwise to the product of step 2), adjust the pH of the system to 5.5-7, and finally obtain a transparent and clear triclosan hand sanitizer gel.

Embodiment 3

[0046] Embodiment 3 contains triclosan gel

[0047] Composition content Triclosan Nanoemulsion 0.7g carbomer 0.6g Triethanolamine 0.8g water Make up to 100g

[0048] The triclosan gel preparation method is as follows:

[0049] 1) Slowly add the prescribed amount of carbomer to 60g of water, and leave it at room temperature for 10 hours to allow the carbomer to fully swell;

[0050] 2) Add the triclosan nanoemulsion and the remaining water to the product of step 1), and stir evenly;

[0051] 3) Slowly add triethanolamine dropwise to the product of step 2) under stirring conditions to adjust the pH of the system to 4.0-6.0, and finally obtain a transparent and clear gel preparation containing triclosan, which can be used for gynecological inflammation treatment or medical ultrasonic coupling agent.

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PUM

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Abstract

The invention relates to gel containing triclosan. The gel containing the triclosan is characterized in that ethyl alcohol does not exist in the gel. The gel containing the triclosan takes the triclosan as a germicidal component, and by means of the technological means of nanoemulsion, the problem that the triclosan is difficult to dissolve in water is solved; carbomer serves as a gel matrix, and a gel preparation which is clear and transparent in appearance is obtained finally. The gel containing the triclosan can be used for the medical fields such as skin sterilization, treatment on gynecological diseases and medical ultrasonic coupling agents.

Description

technical field [0001] The invention belongs to the field of pharmacy and pharmacy, and relates to triclosan-containing gel and its application. Background technique [0002] Carbomer is a kind of polyalkenyl polyether cross-linked acrylic polymer, which forms a polymer with a three-dimensional network structure after swelling in water, and forms a clear and transparent gel after alkali neutralization, and carboxymethyl cellulose ( Compared with hydrogel matrices such as CMC) and methyl cellulose (MC), carbomer gel has low dosage, good hand feeling and good product clarity, and is the most commonly used matrix in hydrogel preparations. [0003] For some water-insoluble substances, it is first necessary to solve the solubility of the insoluble substances when preparing hydrogel formulations. Triclosan is a substance that is extremely insoluble in water, also known as "triclosan", "triclosan", etc., and its chemical name is 2,4,4'-trichloro-2'-hydroxydiphenyl ether, Is a saf...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/085A61K45/00A61K38/40A61K35/74A61K47/32A61P17/00A61P31/04A61P15/00A61K49/22
Inventor 马二利冯宏美庞慧
Owner TIANJIN SPRING BIOPHARM LTD
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