New application of conjugated linoleic acid to promotion of fracture healing

A technology of conjugated linoleic acid and fracture healing, applied in bone diseases, drug combinations, etc.

Inactive Publication Date: 2015-12-30
SUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no relevant research on CLA on fracture healing at home and abroad, so this experiment is designed to study the effect of CLA on fracture healing, in order to improve our understanding of the important role of nutrient metabolism in fracture healing, and provide a basis for our future research on fracture healing. Treatment provides another effective method and approach

Method used

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  • New application of conjugated linoleic acid to promotion of fracture healing
  • New application of conjugated linoleic acid to promotion of fracture healing
  • New application of conjugated linoleic acid to promotion of fracture healing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Effect of conjugated linoleic acid on mouse fracture model

[0018] 1 Animals and main materials

[0019] 1.1 Experimental animals

[0020] 30 female Sprague-Dawley rats, clean grade, body weight (200±15) g

[0021] 1.2 Reagents and instruments

[0022] Conjugated linoleic acid (cis-9, trans-11CLA, 37.6%; trans-10, cis-12CLA, 39.3%; C18:1, 10.1l%; c18:O, 2.04%, Qingdao Aohai Biological Co., Ltd.)

[0023] 2 Experimental methods

[0024] 2.1 Animal grouping

[0025] After fracture modeling, 30 female SD rats were randomly divided into 2 groups, 15 in each group, A blank control group (Control): intragastric administration of normal saline, B intragastric administration of conjugated linoleic acid (CLA) intervention (10g / Kg·diet), it has been reported that this dosage was used to study the effects of conjugated linoleic acid on calcium metabolism and bone metabolism in castrated rats. Guiding Opinions on Experimental Animals".

[0026] 2.2 Establishment of fractu...

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Abstract

The invention discloses new application of a conjugated linoleic acid to promotion of fracture healing. Relevant experiment research on whole animal and molecular cell level shows that the conjugated linoleic acid can further increase fracture healing strength by improving the quality of a rat fracture healing callus so as to achieve the fracture healing promotion. As proved by experiment results, the conjugated linoleic acid can promote fracture healing and enhance in-organism osteoblastic activity and improve ALP (serum alkaline phosphatase) activity. The invention hints that the conjugated linoleic acid has a prospect for developing a fracture healing promotion drug.

Description

technical field [0001] The invention relates to a new application of conjugated linoleic acid for promoting fracture healing, and belongs to the technical field of new application of medicine. Background technique [0002] With the continuous development of the global economy, the rapid expansion, extension and frequency of human communication and mobility, and the rapid development of means of transportation, the incidence of fractures caused by trauma is increasing year by year. Therefore, the repair of fractures has always been a research topic in the field of orthopedics. Hot Issues. Fracture healing is affected by many factors such as the whole body and external factors. At present, relevant research focuses on the influence of fracture internal fixation materials, surgical methods, and drug application on fracture healing, and seldom pays attention to nutrient metabolism is also an important influencing factor. . [0003] Recent studies have reported that conjugated ...

Claims

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Application Information

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IPC IPC(8): A61K31/201A61P19/08A61P19/10
Inventor 陈亮单中书罗宗平
Owner SUZHOU UNIV
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