Composition comprising a combination of an elder extract and a strain of lactobacillus rhamnosus

A technology of Lactobacillus rhamnosus and extracts, which can be used in drug combinations, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., and can solve problems such as unknown limitations of inflammatory responses

Inactive Publication Date: 2016-01-06
PIERRE FABRE MEDICAMENT SAS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

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Method used

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  • Composition comprising a combination of an elder extract and a strain of lactobacillus rhamnosus
  • Composition comprising a combination of an elder extract and a strain of lactobacillus rhamnosus

Examples

Experimental program
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Embodiment 1

[0110] Example 1: Preparation of elderberry extract for use within the scope of the invention

[0111]Elderberry extract obtained from anthocyanin-enriched elderberry juice and dried on maltodextrin. The enrichment was carried out by a membrane filtration method according to the following method: 26 liters of clarified elderberry juice were diluted with 284 liters of water (1 volume of juice corresponds to 11 volumes of water). The 310 liters of liquid thus obtained were stirred and heated to 45° C. and then diafiltered over a first 5 kDa membrane by adding 7 volumes of water per volume of juice (ie 181 L). Then, pass through a 5kDa membrane (5.8m 2 Ultrafiltration on a 5 / 10 kDa membrane pilot per unit surface concentrates the dialysis permeate. The ultrafiltration retentate was thermally concentrated under vacuum at a temperature not exceeding 50° C., and then atomized on a maltodextrin carrier such that the amount of maltodextrin was lower than or equal to 30% (p / p).

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Embodiment 2

[0115] Example 2: Food Supplement in Capsule Form , this composition is especially suitable for adults.

[0116] - Freeze-dried probiotic strain, Lactobacillus rhamnosus: 35mg, ie 5.10 8 UFC;

[0117] - Elderberry extract (Sambucus nigra) according to example 1: 50 mg;

[0118] - Vitamin A: 400 μg;

[0119] - Vitamin B1: 550 μg;

[0120] - Vitamin B2: 700 μg;

[0121] -Vitamin B5: 3mg;

[0122] - Vitamin B6: 700 μg;

[0123] - Vitamin B8: 25 μg;

[0124] - Vitamin B9: 100 μg;

[0125] - Vitamin B12: 0.625 μg;

[0126] - Vitamin C: 40mg;

[0127] - Vitamin D: 2.5 μg;

[0128] - Vitamin E: 6mg;

[0129] - Iron: 2.5 mg;

[0130] - Zinc: 2.5 mg;

[0131] - Selenium: 15 μg;

[0132] - Chromium: 12.5 μg;

[0133] - Manganese: 500 μg;

[0134] - Molybdenum: 12.5 μg.

Embodiment 3

[0135] Example 3: Food supplement in sachet form , this composition is especially suitable for very young children.

[0136] - Freeze-dried probiotic strain, Lactobacillus rhamnosus: 35mg, ie 5.10 8 UFC;

[0137] - Elderberry extract (Sambucus nigra) according to example 1: 25 mg;

[0138] -Vitamin C: 18mg;

[0139] - Vitamin B6: 600 μg;

[0140] -Vitamin E: 2.4mg;

[0141] - Zinc: 2.5 mg;

[0142] - Selenium: 15 μg;

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Abstract

The present invention concerns a combination of an elder (Sambucus nigra) extract and a strain of lactobacillus rhamnosus, intended to stimulate immunity and/or strengthen the immune defences and/or promote an anti-infection and/or anti-inflammatory immune response and/or help maintain vitality.

Description

technical field [0001] The present invention relates to a composition comprising a combination of an elderberry extract and at least one strain of Lactobacillus rhamosus, aimed at stimulating immunity and / or promoting an anti-infective and / or anti-inflammatory response. Background technique [0002] Elderberry or black elderberry (Sambucus nigra L.) belongs to the family Adoxaceae. The genus Sambucus comprises 25 species distributed in temperate regions of the world. Black elderberry (S. nigrassp. nigra) grows widely in Europe (especially Denmark, Italy and Austria), northern regions of Africa and western Asia. Canadian elderberry (S. nigrassp. Canadensis), although a sélection in Canada, originates from northeastern North America and grows in Oregon, Pennsylvania, and Kansas. [0003] The different organs of the elderberry: bark, root, stem, flowers, leaves and fruit are traditionally used in various fields such as medicine, the food industry and the manufacture of tools ...

Claims

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Application Information

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IPC IPC(8): A61K36/35A61P37/04A61P31/00A61P29/00A61P31/16A23L1/29A23L1/30A61K35/747A23L33/15
CPCA61K36/185B32B15/088B32B15/20B32B1/08F16L11/085B32B2307/54B32B2597/00A61K35/747A61P29/00A61P31/00A61P31/12A61P31/16A61P37/04A61K2300/00C08L77/06C08L63/00C08L79/00C08L77/02B32B27/34B32B2377/00C08K5/3412C08K5/353C08L77/00A61K35/74A61K36/35B60R16/08B62D29/043F16L11/045
Inventor C·J·拉泰格C·利博
Owner PIERRE FABRE MEDICAMENT SAS
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