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Gefarnate-containing pharmaceutical composition

The technology of a composition and gelatin, which is applied in the field of pharmaceutical preparations, can solve the problems of unqualified content uniformity, unstable and difficult to solve problems of gelatin tablets, etc., and achieves the effect of simple process operation.

Active Publication Date: 2016-01-20
HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The present invention adopts specific prescriptions and processes such as prefabricated powder to absorb oily raw materials and coating, etc. to solve the problem of poor compressibility and difficult solution after being made into tablets. Uniformity and content uniformity are difficult to pass

Method used

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  • Gefarnate-containing pharmaceutical composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: the preparation of prefabricated powder

[0042] Prescription for prefabricated powder:

[0043] prescription

sodium starch glycolate

gum arabic

Aluminum hydroxide

magnesium hydroxide

silica

HPMC

Prescription 1

7g

53g

152g

58g

100g

40g

Prescription 2

10g

39g

98g

38g

65g

5g

Prescription 3

11g

54g

196g

75g

129g

10g

Prescription 4

11g

113g

245g

94g

161g

15g

Prescription 5

14g

215g

367g

141g

242g

20g

Prescription 6

16g

320g

490g

188g

323g

24g

[0044] Preparation of prefabricated powder:

[0045] a. The auxiliary materials are passed through an 80-mesh sieve and set aside;

[0046] b. Preparation of gum arabic solution: take gum arabic and heat water, dissolve, and cool to room temperature.

[0047] c. Mix aluminum hydroxide, magnesiu...

Embodiment 2

[0052] Prescription 7:

[0053]

[0054] Process:

[0055] a. Put 80% prefabricated powder in a wet mixing granulator, slowly add gefar ester while stirring, granulate, take out, and sieve;

[0056] b. Add sodium carboxymethyl starch, the remaining prefabricated powder and magnesium stearate, mix well, take out, compress into tablets, and obtain gefarcetin tablets;

[0057] c. Coating by conventional method.

Embodiment 3

[0059] Prescription 8:

[0060]

[0061]

[0062] Process:

[0063] a. Put 40% prefabricated powder in a wet mixing granulator, slowly add gefar ester while stirring, granulate, take out, and sieve;

[0064] b. Add the remaining prefabricated powder and magnesium stearate, mix evenly, take out, and press into tablets to obtain gefarcetin tablets;

[0065] c. Coating by conventional method.

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PUM

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Abstract

The invention relates to gefarnate-containing pharmaceutical composition. The gefarnate-containing pharmaceutical composition mainly contains gefarnate and pre-prepared powder. The pre-prepared powder absorbs oily raw materials firstly and then matched with other proper auxiliaries, the mixture is compressed into tablets, and the technical defects of very poor compressibility, instability and the like after gefarnate as an oily raw material is compressed into tablets are overcome. The gefarnate-containing pharmaceutical composition has stable quality, and a production process is simple to operate, low in cost and quite suitable for industrial production.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a pharmaceutical composition of gefarate. Background technique [0002] The digestive system is a common and frequently-occurring disease, and it is also a chronic disease that easily recurs. So far, there is no effective means for a complete cure. Studies have shown that digestive system diseases are caused by gastric mucosal invasion factors (including gastric acid, pepsin, abnormal motility, bile acid, certain drugs, alcohol, nicotine) and mucosal protective factors (including mucosal barrier, mucosal blood flow, prostaglandins, caused by an imbalance between bicarbonate secretion and epithelial regeneration). In my country, the drugs for the treatment of peptic ulcer mainly consist of proton pump inhibitors, H2-receptor antagonists and gastric mucosal protective agents. With the advent of proton pump inhibitors, peptic ulcer healing is not a difficult problem to s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/28A61K31/232A61K47/38A61P1/04
Inventor 卢良华
Owner HANGZHOU HUADONG MEDICINE GRP PHARMA RES INST
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