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External preparation containing non-steroid anti-inflammatory drug microemulsion and used for skin

A technology for non-steroidal anti-inflammatory drugs and external preparations, which is applied in the field of skin external preparations to prepare the preparations, and achieves the effects of good stability, good penetration-promoting effect, and reduced dosage

Active Publication Date: 2016-02-03
BEIJING TIDE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no report on the application of microemulsion to the preparation of non-steroidal anti-inflammatory drug external patches

Method used

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  • External preparation containing non-steroid anti-inflammatory drug microemulsion and used for skin
  • External preparation containing non-steroid anti-inflammatory drug microemulsion and used for skin
  • External preparation containing non-steroid anti-inflammatory drug microemulsion and used for skin

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The prescription composition of the ketogloben micro -lacture paste sticker:

[0037]

[0038] Preparation:

[0039] 1. Put 1g ketones, 5GIPM, 10G Cromiti, 5G Twen 80, and 2G, 83 and 83 into a cup, stir and dissolve, and then add it to 100g of ultra -pure water.It

[0040] 2. Mix the above -mentioned prepared micro -emulsion with 30g of gel and 10g polyacrylol alcohol to be uniform to make the obtaining drug solution;

[0041] 3. After scattered 30g of polyacryonic acid, 1g of glycine, 40g of carboxymethyl cellulose, 50g titanium dioxide, and 476g glycerin, add it to the above main medicine solution and continue to stir about 30min;

[0042] 4. Apply the above prepared paste to the back lining layer, cover the protective layer, dry, and cut it on demand to the specified size.

Embodiment 2

[0044] The prescription composition of the ketogloben micro -lacture paste sticker:

[0045]

[0046] Preparation:

[0047] 1. Put 10g ketone Lang, 60gipm, 50G Cromiti, 50G Twen 80, 40G, 83 and 83 into a cup and stir to dissolve, and then add it to 250g of ultra -pure water.It

[0048] 2. Mix the above -mentioned prepared microfoundal with 80g gum (aqueous solution), 60g polyacrylisol (aqueous solution) uniform to make the obtaining medicine solution;

[0049] 3. After the 100g polyacryonic acid, 3g of glycopine, 40g of carboxymethyl cellulose sodium, 10g titanium dioxide, and 147g glycerin are dispersed evenly, add it to the above main medicine solution and continue to stir about 30min;

[0050] 4. Apply the above prepared paste to the back lining layer, cover the protective layer, dry, and cut it on demand to the specified size.

Embodiment 3

[0052] The prescription composition of the ketogloben micro -lacture paste sticker:

[0053]

[0054] Preparation:

[0055]1. Put 4g ketone aura, 25g tritencel glycerin, 20g Cromit, 20g polyoxyethylene alcohol oil, 5g skeleton 83 into a cup and stir to dissolve, and then add it to 100g of ultra -pure water, use the average qualityMillet emulsification, preparing micro -milk;

[0056] 2. Mix the above -mentioned prepared microfounds with 50g of gum (aqueous solution), 120g polyacryl (aqueous solution), uniformly to make the obtaining medicine solution;

[0057] 3. After scattered 70g of sodium polyacrylate salt, 2g of glychydroxyed, 80g of carboxymethyl cellulose, 20g kaolin, 228g glycerin, add it to the above main medicine solution, and continue to stir about 30min;

[0058] 4. Apply the above prepared paste to the back lining layer, cover the protective layer, dry, and cut it on demand to the specified size.

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Abstract

The invention provides a non-steroid anti-inflammatory drug microemulsion-based gel patch with good stability and good permeation promotion effect. The patch contains a non-steroid anti-inflammatory drug microemulsion, a polymer gel skeleton, a cross-linking agent, a tackifier, a humectant, a filler and other pharmaceutically acceptable excipients. The non-steroid anti-inflammatory drug microemulsion contains a non-steroid anti-inflammatory drug, an emulsifier, a co-emulsifier, an oil phase and pharmaceutically acceptable excipients. According to the invention, the oil phase, the emulsifier and the co-emulsifier used for preparing the microemulsion can be used as drug permeation promoters at the same time and are cooperated with the microemulsion to promote percutaneous permeability of the drug, so the percutaneous permeability of the drug is effectively improved; thus, the residual quantity of the drug in the patch is reduced and the utilization degree of the drug is improved.

Description

Technical field [0001] This application involves a micro -milk agent that involves non -steroidal anti -inflammatory drugs (NSAIDS), especially for skin exterior preparation containing non -steroidal anti -inflammatory micro -milk micro -milk, and also provides methods for preparing the preparation. Background technique [0002] Non -steroidal anti -inflammatory drugs (NSAIDS) compounds are effective pain and inflammation in multiple treatment schemes.At present, the dose of capsules, tablets and other doses are administered orally. Due to its effectiveness, oral non -steroidal anti -inflammatory drugs are used to treat acute and chronic shutdown pain and inflammation.At the same time, NSAIDS is also widely used for postoperative pain, usually administration or oral administration in intravenous veins.Oral NSAIDS will have a variety of severe gastrointestinal complications, including gastric ulcers, digestive perforation, bleeding, colon ulcers, and colitis. It seriously affects ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/405A61K31/192A61K47/42A61K47/44A61P29/00
Inventor 赵焰平张丽梅郭映君田莉莉张伟强刘亚男
Owner BEIJING TIDE PHARMA
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