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Intelligent PSA (prostate specific antigen) detection system and sensor preparation method thereof

An intelligent detection and sensor technology, applied in the direction of electrochemical variables of materials, etc., can solve the problems of unmentioned system tracking detection, high requirements for biological antibody preservation, false positives, etc., to avoid false positive test results, avoid excessive treatment, The effect of low detection limits

Active Publication Date: 2016-02-03
SHENZHEN HANK BIOLOG ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Chinese patent CN101070345B discloses a method for detecting prostate-specific antigen (PSA), using the monoclonal antibody against prostate-specific antigen invented by the patent, that is, using the PSA baggage detection matrix to detect PSA by competitive ELISA, another method The double-antibody sandwich method ELISA of anti-prostate specific antigen monoclonal antibody is used to detect PSA. The PSA detection range of monoclonal antibody is 0-2048ng / mL. This invention relates to biological monoclonal antibody, and the specificity of antibody in the detection method The requirements are very high, otherwise there will be a large number of false positive results. In addition, the requirements for the preservation of biological antibodies are high. If the preservation is not done properly, it will cause great errors in actual operation.
But the invention does not mention system tracking detection

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] A preparation method of an electrochemical sensor, the steps are as follows:

[0030] (1) Electrospinning: use nano-gold suspension and polylactic acid (PLA) acetone solution to prepare nano-gold organic suspension; add the nano-gold organic suspension to the liquid propeller of electrospinning equipment In electrospinning, the nano-gold organic suspension is ejected from 5 independent spray heads, the receiving end is a grounded glassy carbon electrode, the distance between the spray head and the glassy carbon electrode is 5cm, and the spinning voltage 35kV, and the electrospinning time is 3min. After the electrospinning, the obtained spun film does not completely cover the glassy carbon electrode.

[0031] Wherein, the mass percentage of the nano-gold suspension is 0.5%, the mass volume percentage of the polylactic acid (PLA) acetone solution is 10 wt%, and the mass ratio of the nano-gold suspension to PLA is 1:10.

[0032] (2) Preparation of magnetic nanoparticle su...

Embodiment 2

[0041] An intelligent detection system for tracking and detecting prostate-specific antigen (PSA).

[0042] The intelligent detection system for tracking and detecting PSA includes: an electrochemical sensor module, an intelligent storage module, a wireless communication module, and an intelligent analysis module.

[0043] The electrochemical sensor module consists of an immunoelectrochemical sensor sensitive to PSA.

[0044] The data measured by the electrochemical sensor is transmitted to the intelligent storage module, and then the data is transmitted to the intelligent analysis module through the wireless communication module, and the PSA data trend is analyzed to help doctors more accurately assess the risk of prostate cancer in patients risk.

[0045] The preparation method of described electrochemical sensor, the steps are as follows:

[0046] (1) Electrospinning: use nano-platinum suspension and polylactic acid (PLA) acetone solution to prepare nano-platinum organic ...

Embodiment 3

[0053] A preparation method of an electrochemical sensor, the steps are as follows:

[0054] (1) Electrospinning: use nano-gold suspension and polylactic acid (PLA) acetone solution to prepare nano-gold organic suspension; add the nano-gold organic suspension to the liquid propeller of electrospinning equipment In electrospinning, the nano-gold organic suspension is ejected from 10 independent spray heads, and the receiving end is a grounded glassy carbon electrode. The distance between the spray head and the glassy carbon electrode is 7cm, and the spinning voltage 60kV, the electrospinning time is 8min, after the electrospinning is finished, the obtained spun film does not completely cover the glassy carbon electrode.

[0055] Wherein, the mass percentage of the nano-gold suspension is 1%, the mass volume percentage of the polylactic acid (PLA) acetone solution is 20 wt%, and the mass ratio of the nano-gold suspension to PLA is 1:20.

[0056] (2) Preparation of magnetic nano...

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Abstract

The invention discloses an intelligent detection system for detecting prostate specific antigens (PSA) by tracking, and a preparation method of an electrochemical sensor serving as a core module of the intelligent detection system. According to the intelligent detection system and the preparation method, modification electrodes such as electrospun nanogold (platinum) and magnetic nano particles are adopted, and the electrochemical sensor is constructed. The intelligent PSA detection system can track the PSA level of a screened object for a long time to help a doctor to estimate the risk that the screened object has a prostate cancer more precisely, thus avoiding a false positive detection result and avoiding excessive treatment, and even a treatment error. The intelligent detection system has the characteristics of sensitivity, specificity and high selectivity, and has an important application prospect in the field of medical clinical diagnosis.

Description

technical field [0001] The invention relates to a detection system for prostate specific antigen, in particular to a PSA intelligent detection system and a sensor preparation method thereof, belonging to the field of biological detection. Background technique [0002] Prostate-specific antigen (prostate specificantigen, PSA) is an antigen related to prostate cancer, which belongs to glycoprotein substances, and is recognized as a good tumor marker for the diagnosis of prostate cancer. [0003] The standard prior art method for assessing prostate cancer risk is to measure the level of prostate-specific antigen (PSA) in the blood. [0004] However, clinical data prove that the PSA prostate cancer screening method does not reduce the prostate cancer-related mortality of the screened population, but causes too many unnecessary treatments. The reason for this problem is that although the screening method based on PSA level has high sensitivity, its specificity is not good. There...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/26G01N27/30
Inventor 孙京华潘正海
Owner SHENZHEN HANK BIOLOG ENG CO LTD
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