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Application of oxymatrine and derivatives thereof to prepare medicines treating skin lymphoid hyperplasia related diseases

A derivative, the technology of matrine, applied in the field of medicine, can solve the problems of exacerbating immune imbalance and less application

Active Publication Date: 2016-02-10
施惠娟
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

(2) Systemic treatment 1. Chemotherapy Single-drug chemotherapy such as methotrexate and chlorambucil can be used in the treatment of advanced MF. Combined chemotherapy often exacerbates immune imbalance and is rarely used

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Comparison of Acute Toxic Effects of Oxymatrine on Mice

[0023] Kunming mice were randomly divided into a normal control group and a test drug group, with ten mice in each group, half male and half male. In addition to the normal control group, the test drug group was injected intraperitoneally (ip) with a large dose of oxymatrine once, observed continuously for 7 days, and recorded the death time and number of animals.

[0024] The results showed that when the dose of oxymatrine was 950mg / kg, it had great toxicity, and 9 out of 10 mice died.

[0025] Comparison of acute toxic effects of epioxymatrine, glycyrrhizic acid and their combination (ip once) on mice

[0026] group Dose (mg / kg) Deaths / Total normal control group 0 0 / 10 bitter 950 9 / 10

[0027] Remarks: "Bitter": means oxymatrine.

Embodiment 2

[0029] Clinical Observation on Oxymatrine Treating a Case of Early Stage Mycosis Fungoides

[0030] 1 Materials and methods

[0031] 1.1 Clinical data The patient, Xin XX, female, 56 years old, had repeated infiltrating erythema with pigmented purpura-like skin lesions on both lower limbs for more than 1 year. He went to Ningxia People's Hospital and Peking Union Medical College Hospital successively. The histopathological diagnosis was consistent with early stage mycosis fungoides. He had received black light therapy (UVB) treatment, but the effect was not good, and the skin lesions gradually aggravated. No serious visceral diseases such as liver and kidney dysfunction.

[0032] 1.2 Treatment method The patients were intravenously infused with oxymatrine injection 0.6g100ml / d; 8 weeks was a course of treatment, and the curative effect was judged after the course of treatment was over.

[0033] 1.3 Safety evaluation Before and after treatment, blood and urine routines and bi...

Embodiment 3

[0039] Clinical Observation on Oxymatrine Treating a Case of Rosai-Dorfman Disease

[0040] 1 Materials and methods

[0041] 1.1 Clinical data The patient, Li XX, female, 64 years old, complained of "Lesions on the legs for 1 year, skin lesions on the chest for 3 months, accompanied by pain". He went to the First Hospital of Yinchuan, Ningxia three months ago and was diagnosed with "skin tuberculosis". After being given "rifampicin and isoniazid" treatment for one month, the skin lesions did not improve and gradually increased. University General Hospital. Clinical examination: no obvious abnormalities in the heart, lungs and abdomen, and no enlarged superficial lymph nodes in the whole body. Dermatological conditions: a nodular plaque with a diameter of about 6 cm and a dark red color was found on the left chest and the lower part of the right leg. Dark yellow is visible in some areas of the foundation. Immunoglobulin+complement, erythrocyte sedimentation rate, CEA+CA199+C...

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Abstract

The invention relates to application of pharmaceutically-acceptable forms and derivatives of oxymatrine(oxymatrine, matrine and iosmatrine ) to prepare medicines controlling skin lymphoid hyperplasia related diseases (comprising mycosis fungoides, Paget reticulosis, CD30+ lymphoproliferative disease, regressing atypical histiocytosis, hydroa vacciniforme-like cutaneous lymphoproliferative disease, chronic actinic dermatitis, skin lymphocytic infiltration, pseudolymphoma, cutaneous plasmacytosis, skin inflammatory pseudotumor, benign cutaneous type mastocytosis, langerhans' cell histiocytosis, indeterminate cell histiocytosis, xanthogranulomatous cholecystitis, benign cephalic histiocytosis, generalized eruptive histiocytoma, progressive nodular histiocytosis, papular xanthoma, xanthoma disseminatum, and rosai-dorfman disease).

Description

technical field [0001] The invention belongs to the field of medicine, and relates to the application of matrine and its derivatives in the preparation of medicines for treating skin lymphoproliferation-related diseases. The medicine is matrine (oxymatrine, matrine, isomatrine) or a pharmaceutically acceptable form or derivative thereof and a medicine box containing the medicine. Background technique [0002] In recent years, with the rapid development of knowledge and technology in cell and molecular biology, the source and composition of lymphoreticular cells have been further understood. At present, it is believed that it is mainly composed of lymphocytes and mononuclear phagocytes, cells of the mononuclearphagocyteandimmunoregulatoryeffector (M-PIRE) system, and various scaffold cells, including lymphocytes, monocytes, histiocytes and reticulocytes, etc. . It is known that lymphocytes are not only divided into T cells and B cells, but also have subtypes. Monocytes are...

Claims

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Application Information

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IPC IPC(8): A61K31/4375A61P17/00A61P7/00A61P35/00
Inventor 施惠娟
Owner 施惠娟
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