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Uses of cyclic adenosine monophosphate or derivatives thereof in omental hemorrhage after surgical operation

An adenosine phosphate derivative and cyclic adenosine monophosphate technology, applied in the field of cyclic adenosine monophosphate or its derivatives, can solve the problems of slow hemostatic effect, life-threatening patients, etc. The effect of reducing the degree of damage

Active Publication Date: 2016-02-24
SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the method of reducing postoperative subomental hemorrhage is mainly to inject hemostatic drugs during or after the operation, but the hemostatic effect of the current hemostatic drugs is slow, and they are often helpless when encountering sudden and large-scale bleeding, resulting in The patient is in danger of life and cannot meet the requirements

Method used

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  • Uses of cyclic adenosine monophosphate or derivatives thereof in omental hemorrhage after surgical operation
  • Uses of cyclic adenosine monophosphate or derivatives thereof in omental hemorrhage after surgical operation
  • Uses of cyclic adenosine monophosphate or derivatives thereof in omental hemorrhage after surgical operation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Main materials

[0027] Cyclic adenosine monophosphate (purchased from Shanghai Yuanye Biotechnology Co., Ltd.), normal saline, distilled water, syringe, optical microscope, homogenizing glass dish, and surgical instruments.

[0028] 2. Subjects

[0029] Adult male rats (purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.), male, weighing 280-350 g, were reared in a single cage before surgery, kept at a body temperature of 18-22 degrees Celsius, free to eat and drink, and raised in a quiet, dark environment .

[0030] 3. Experimental method

[0031] Adult healthy rats were divided into four groups as follows:

[0032] Operation group A: 10 rats, oppressed or knotted to block the blood vessels of intestinal blood, after 5 minutes, intestinal subomentum hemorrhage, did not relieve the oppressed or knotted, and then injected 2ml cyclic adenosine monophosphate solution (2mg cyclic adenosine monophosphate Adenosine was dissolved in 2ml0.9% so...

Embodiment 2

[0040] This embodiment uses cyclic adenosine monophosphate meglumine to replace cyclic adenosine monophosphate, adopts the main materials of embodiment 1, the same experimental object of embodiment 1, and adopts the operation group A and control group B in the experimental method in embodiment 1 Experimental method to obtain the relationship between the amount of bleeding over time, such as image 3 shown.

Embodiment 3

[0042] This embodiment uses dibutyryl cyclic adenosine phosphate calcium to replace cyclic adenosine monophosphate, adopts the main materials of embodiment 1, the same experimental objects of embodiment 1, and adopts the experiment of operation group A and control group B in the experimental method in embodiment 1 method to obtain the relationship between the amount of bleeding over time, such as Figure 4 shown.

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Abstract

The invention relates to uses of cyclic adenosine monophosphate or derivatives thereof, and specifically relates to uses of cyclic adenosine monophosphate or derivatives thereof in omental hemorrhage after surgical operation. Low dosage of cyclic adenosine monophosphate or derivatives can effectively reduce amount and area of omental hemorrhage after surgical operation, reduce hemostasis time of omental hemorrhage after surgical operation, and relieve the damage degree of human body.

Description

technical field [0001] The present invention relates to the use of cyclic adenosine monophosphate or derivatives thereof, in particular to the application of cyclic adenosine monophosphate or derivatives thereof in postoperative subretinal hemorrhage. Background technique [0002] Cyclic adenosine monophosphate is cAMP, the CAS number is 60-92-4, and the chemical formula is C 10 h 12 N 5 o 6 P, is a derivative of nucleotides. It is an important substance that transmits nitrogen-containing hormones in the human body. When nitrogen-containing hormones are secreted from a certain cell, they travel to target cells with body fluids and act on specific receptors on the cell membrane to activate adenylyl cyclase in the cell membrane. , the enzyme in Mg 2+ or Ca 2+ Under the condition of existence, the adenosine triphosphate (ATP) in the cell is converted into cAMP, and then protein kinase is activated by cAMP, and various enzyme systems are activated by protein kinase to have...

Claims

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Application Information

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IPC IPC(8): A61K31/7076A61P7/04A61P1/00
Inventor 傅苗青厉达中陈宇东
Owner SHANGHAI JINCHENG PHARMACEUTICAL CO LTD
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