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Method for detecting synthetic musk

A technology of artificial musk and detection method, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of differentiation, inability to control the quality of medicines more comprehensively, and the inability to judge the safety and effectiveness of finished products, so as to achieve the goal of controlling the quality of medicines Effect

Active Publication Date: 2016-03-23
山东宏济堂制药集团股份有限公司
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Problems solved by technology

[0011] The above control points cannot distinguish whether the musk used in the drug is an artificial musk used for medicinal purposes, and cannot be distinguished from other artificial musks used as fragrances, so that it is impossible to judge the safety and effectiveness of the finished product
At present, Shandong Hongjitang Pharmaceutical Group Co., Ltd. is the only market supplier of muscone used in domestic medicinal artificial musk. The artificial musk Chinese patent medicine preparations sold on the market only detect the relevant muscone components. In fact, Shandong Hongjitang Pharmaceutical Group The by-product 4-methylcyclopentadecanone (the method disclosed in the patent with the patent publication number CN1994998A) of "Muskone" prepared by the company by the closed-loop method is also an active ingredient; in the detection method of the prior art, only The detection method of artificial musk with a single component of muskone cannot accurately judge the safety and effectiveness of the drug, and cannot more comprehensively control the quality of the drug

Method used

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  • Method for detecting synthetic musk
  • Method for detecting synthetic musk
  • Method for detecting synthetic musk

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Experimental program
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Effect test

Embodiment 1

[0067] Chromatographic conditions and system suitability test

[0068] The temperature of the column was programmed, the initial temperature was 140°C, kept for 10 minutes, then increased to 170°C at a rate of 2°C per minute, kept for 5 minutes, the temperature of the injection port was 220°C, and the temperature of the hydrogen flame ion detector was 250°C.

[0069] Preparation of the reference medicinal solution Precisely weigh the artificial musk reference medicinal material, add methanol and ultrasonically treat it, discard the insoluble matter, and make a reference medicinal material solution containing 20 mg of artificial musk per 1 ml, shake well, and filter to obtain final product;

[0070] Preparation of the reference substance solution Accurately weigh the muscone reference substance and add methanol to make a reference substance solution containing 1mg of muscone per 1ml, shake well, filter, and obtain;

[0071] Preparation of the test solution: Take the Chinese pat...

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Abstract

The invention discloses a method for detecting synthetic musk. Muscone, 4-methyl-cyclopentadecanon, musk lactone, dehydrogenated musk lactone and C18H2803 of synthetic musk in a medicine are qualitatively detected, so as to judge whether the medical synthetic musk conforming to the regulations of the pharmacopeia is used in the medicine. Through the method, the safety and effectiveness of the medicine can be judged accurately, and the medicine quality is controlled more comprehensively.

Description

technical field [0001] The invention relates to the technical field of artificial musk identification and detection, in particular to a detection method for artificial musk. Background technique [0002] As a traditional Chinese medicine, musk is widely used in the field of medicine and cosmetics. After musk deer is listed as a national first-class protected wild animal, natural musk from male musk deer can only be used in a few varieties of traditional Chinese medicine designated by the state. In order to protect wild animals and at the same time meet the clinical needs of traditional Chinese medicine, the only medicinal artificial musk in China has been successfully developed, and the approval number is Z20040042. Pharmacological and clinical trials have proved that the main pharmacological effects of artificial musk are basically the same as those of natural musk, the physical properties are similar, the clinical curative effect is definite, and it is safe to use. It can ...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/90
CPCG01N30/02G01N30/90G01N2030/025
Inventor 张桥宋骁李海燕李樱武勇
Owner 山东宏济堂制药集团股份有限公司
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