50 results about "Synthetic musk" patented technology

The invention discloses a quality testing method for fingerprint of herbal medicine musk. The method includes establishing a gas chromatographic fingerprint of the musk by gas chromatography, and analyzing chemical components of different types of musk by gas chromatography and mass spectrometry. A test sample is processed by specific process, chromatographic detection is optimized, and tests show that the method is stable, precise and repeatable. Three established reference musk fingerprints are well specific. Similarity of the three types of musk is researched under integration of non-integration conditions of muscone, and more accurate basis is provided for testing quality of the three different types of musk. In addition, common compounds of the three types of musk are obtained by identification by GC-MS (gas chromatography and mass spectrometry) and can be used as basis for further identification of synthetic musk, domestic musk and natural musk.

The invention relates to a method capable of simultaneously measuring organochlorine pesticide concentration and synthetic musk concentration in human serum. According to the method, the aim of measuring organochlorine pesticide and synthetic musk in the serum is realized through a chemical pretreatment method of liquid-liquid extraction, gel permeation chromatography and silica gel alumina column, in combination with a detection technology of gas chromatography-electron capture detection (GC-ECD) and gas chromatography-mass spectrometry (GC-MS). The method provided by the invention belongs to the technical field of physico-chemical analysis measurement of organic chemicals. In the method provided by the invention, the serum pretreatment process comprises organic solvent liquid-liquid extraction, gel permeation chromatographic column degreasing, silica gel alumina column purification, separation and concentrating to constant volume, finally, GC-ECD and GC-MS are used for detection, detection spectrograms of organochlorine pesticide and synthetic musk in serum sample are respectively obtained, and concentration values of organochlorine pesticide and synthetic musk in the serum are calculated through a special formula. The method provided by the invention is a steady, relatively high-sensitivity and high-precision effective measurement method.

The invention discloses a preparation for restoring consciousness and calming nasal mucosa and a preparation method thereof. The preparation is a nasal drug composition preparation for treating cerebrovascular diseases. The nasal drug composition preparation is prepared from 30 to 50 parts by weight of borneol (or L-borneol), 3 to 9 parts by volume of synthetic musk essential oil, 2 to 6 parts by volume of turmeric root tuber essential oil and 30 to 40 parts by weight of cape jasmine fruit extract. The nasal drug composition preparation produces treatment effects through being absorbed by nasal mucosa and the nasal mucosa absorption process is mainly a passive absorption process. Drugs and fat-soluble drugs having relative molecular weight less than 1000 can be absorbed easily. The nasal drug composition preparation has high bioavailability near to 100%.

The invention relates to a method which can stably detect the concentration of synthetic musk in breast milk, and the purpose of measuring the concentration of the synthetic musk in the breast milk is achieved through the combined method of the gel chromatographic column chemical pretreatment method and the gas chromatography-mass spectroscopy. The method belongs to the technical field of physical and chemical analysis and measurement of organic chemical materials. The pretreatment process of the breast milk in the method of the invention comprises liquid-liquid extraction and the step of passing through the gel chromatographic column, the solution after the concentration by eluting solution is processed by passing through a small silica gel column and finally enters a gas chromatograph-mass spectrograph (GC-MS) for carrying out the detection, thereby obtaining a mass spectrum curve diagram containing various synthetic musk in the breast milk sample and then utilizing the specific formula for calculating the content of the musk contained in the breast milk. The method of the invention is an effective measurement method which is stable and has higher accuracy.

The invention discloses a method for detecting synthetic musk. Muscone, 4-methyl-cyclopentadecanon, musk lactone, dehydrogenated musk lactone and C18H2803 of synthetic musk in a medicine are qualitatively detected, so as to judge whether the medical synthetic musk conforming to the regulations of the pharmacopeia is used in the medicine. Through the method, the safety and effectiveness of the medicine can be judged accurately, and the medicine quality is controlled more comprehensively.

The invention relates to a cerebral apoplexy treatment medicament and a preparation method thereof. The cerebral apoplexy treatment medicament comprises, by weight proportion, 10-20 parts of radix notoginseng, 25-35 parts of radix salviae miltiorrhizae, 5-15 parts of flos carthami ,10-20 parts of Geosaurus, 10-20 parts of angelica sinensis, 10-20 parts of Sichuan lovage rhizome, 5-15 parts of peony root and 0.1-1 part of synthetic musk. With radix notoginseng and radix salviae miltiorrhizae as major ingredients, the cerebral apoplexy treatment medicament is used for treating cerebral apoplexy. Compared with other traditional Chinese medicine formulas, the cerebral apoplexy treatment medicament is more reliable in treating effect and safe with no evident side effects. The cerebral apoplexytreatment medicament is capable of promoting blood circulation to remove blood stasis, is used for cerebral thrombosis convalescence, and is used for treating symptoms of hemiplegia, wrying mouth andtongue, difficult speech, dark tongue, ecchymosis and the like.

The invention discloses mosquito repellent for children and a preparation method of the mosquito repellent. The mosquito repellent comprises raw materials in parts by weight as follows: 3-7 parts of argy wormwood leaves, 6-9 parts of lemons, 4-6 parts of chamomile, 2-4 parts of synthetic musk, 1-4 parts of fresh ginger, 1 part of vitamin B and 20-40 parts of ethyl alcohol. The mosquito repellent for children has good mosquito repelling effect and reasonable formula, does not have toxic and side effects on children, is low in production cost and facilitates mass production.

The invention provides a medicinal composition and a preparation method thereof. The medicinal composition consists of the following bulk pharmaceuticals in parts by weight: 2-5 parts of in-vitro-cultured calculus bovis, 10-25 parts of synthetic musk, 60-170 parts of frankincense processed with vinegar and 60-170 parts of myrrh processed with vinegar. The invention further provides an application of the medicinal composition to preparation of a medicament for treating malignant tumor accompanied with gall-stone. As proved by clinical test, the medicinal composition has a remarkable curative effect on gall-stone accompanied with malignant tumor, and can be used for relieving tumor symptoms.

The invention discloses a traditional Chinese medicine preparation for treating traumatic injury, and a preparation method thereof. The traditional Chinese medicine preparation is prepared from synthetic musk, borneol, olibanum (processed with vinegar), safflower, sangusis draconis, angelica sinensis, cutch, lignum dalbergiae odoriferae, pseudo-ginseng, myrrh (processed with vinegar) and cinnabar according to certain proportions. The preparation method comprises the following steps of grinding synthetic musk and borneol into fine powder respectively; smashing residual medicines of olibanum, safflower, sangusis draconis, angelica sinensis, cutch, lignum dalbergiae odoriferae, pseudo-ginseng and myrrh into fine powder; screening the smashed powder; sterilizing by irradiation of Co-60; mixing uniformly; granulating; drying; shaping particles; adding cinnabar powder, synthetic musk fine powder and borneol fine powder; mixing uniformly and filling in capsules to obtain the traditional Chinese medicine preparation. The preparation provided by the invention increases accuracy of medicine sub-packaging dosage, guarantees stabilization of dosage, guarantees effectiveness and security of the medicine, and increases medicine stability.

The invention discloses a flowery flavor perfume composed of the following raw materials: santalol, tarragon, vanillin, angelica sinensis, muscone, salvia sclarea l., synthetic musk, vetiver, ambrein, linalool, pogostemon cablin, lavender, isoeugenol, coumarin, methylionone, heliotropin, methyl atratate, cananga odorata, bergamot, cinnamon acetate, jasmine, benzoin, rose, ethanol, and wintergreen oil. The perfume prepared by the method has elegant fragrance, is capable of increasing woman confidence, and is especially suitable for ordinary women to use.

The invention relates to an application of Xueshuan Xinmaining to preparation of a medicine for treating vascular dementia and belongs to the field of traditional Chinese medicine. The Xueshuan Xinmaining medicine is prepared by the following active ingredients in parts by weight: 450-550 parts of ligusticum wallichii, 450-550 parts of salvia miltiorrhiza, 200-300 parts of sophora flower, 100-150 parts of hirudo, 200-300 parts of pubescent holly root, 1.00-1.50 parts of synthetic musk, 10.0-15.0 parts of calculus bovis factitius, 20-30 parts of ginseng stem-leaf saponin, 2.0-3.0 parts of borneol, and 1.00-1.50 parts of venenum bufonis. Xueshuan Xinmaining has the functions of supplementing qi, activating blood circulation, and treating vascular dementia.

The present invention discloses a powder preparation for curing ophthalmopathy and its preparation method. Said powder preparation has obvious therapeutic effect for curing several ophthalmopathies of ocular red swelling, pain and itching of eye, dacryorrhea, trachoma and marginal blepharitis, etc. Said powder preparation is made up by using calcined smithsonite, amber, synthetic bovine bezoar, borneol, synthetic musk, borax, pearl and sal ammoniac through a certain preparation process. Said invention also provides the concrete steps of said preparation process.

The invention discloses a medicine for treating benign prostatic hyperplasia hypertrophy and a preparation method thereof. The medicine includes following traditional Chinese medicines: astragalus membranaceus, Chinese yam, common macrocarpium, oldenlandia diffusa, atractylodes macrocephala, poria cocos, Sichuan dioscorea septemloba, pangolin, salviae miltiorrhizae, rhizoma sparganii, curcuma zedoary, stir-fried cortex phellodendri, schisandra chinensis, semen coicis, honey-fried radix glycyrrhizae, divaricate saposhnikovia, leech and synthetic musk, while a western medicine formula includes vitamin B. The medicine is prepared through compatibility of Chinese medicines and western medicines and through reasonable preparation. The medicine is good in curative effect on the benign prostatic hyperplasia hypertrophy, is short in treatment course, can cure both exterior and interior, is high in curative rate, is not liable to cause relapse, is less in adverse reaction, is easy to prepare and is safe to use. The medicine is an excellent formula for treating the benign prostatic hyperplasia hypertrophy. Clinical experience for many years proves that the medicine is higher than 90% in curative effective rate and is 100% in total effective rate.

The invention discloses a traditional Chinese medicine for treating a coronary heart disease. The traditional Chinese medicine is characterized by being prepared from the following medicinal materials in parts by weight: 15-25 parts of pseudo-ginseng, 15-25 parts of salviae miltiorrhizae, 15-25 parts of saffron crocus, 10-20 parts of synthetic musk, 5-15 parts of prepared fleece flower roots, 5-15 parts of acanthopanax, 5-15 parts of spina date seeds, 5-15 parts of angelica sinensis, 5-15 parts of platycladi seeds, 5-15 parts of radix paeoniae alba, 5-15 parts of American ginseng and 2-8 parts of borneol. The traditional Chinese medicine is applied to the diseases such as the coronary heart disease, stenocardia, early myocardial infarction, palpitation and chest distress, and is capable of nourishing yin, tonifying the kidneys, reinforcing qi, nourishing blood, promoting blood circulation to remove blood stasis, and regulating qi to alleviate pain; with American ginseng as monarch and musk as minister in the formula, monarch and minister are combined to reach the effects of exciting foundation, consolidating constitution and recovering vigor; the salvia miltiorrhiza is an assistant; the saffron crocus is a guide medicine; and the traditional Chinese medicine is scientific and reasonable in composition, unique in compatibility and significant in curative effect, has the characteristics of treating both symptoms and root causes, is free of a toxic or side effect and fast in acting, significant in economic and social benefits, simple in production method, low in cost, and suitable for individual clinics for prescribing medicines to treat diseases, and is also suitable for preparation various hospitals and production of Chinese patent medicines in pharmaceutical factories.

The present invention discloss an ointment for curing ophthalmopathy and its preparation method. Said medicinal ointment is made up by using vaseline, smithsonite, amber, artificially-synthetic bovine bezoar, borneol, artificially-synthetic musk, wool fat, liquid paraffin wax, borax, pearl and sal ammoniac, and can obtain good therapeutic effect for curing several ophthalmopathies of acute contagious conjunctivitis, pain and itching of eye, tearing on exposure to wind, trachoma and marginal blepharitis, etc. Said invention also provides its preparation method and concrete steps.

The invention relates to a sublingual thrombolytic anti-bacterial spray and a preparation method thereof, and belongs to the technical field of anti-bacterial sprays. According to the technical scheme, crocus sativus, herba bidentis bipinnatae, bambusae caulis in taenias, astmgali radi, radix angelicae sinensis, artemisiae argyi folium, lycii fructus, hirudo, fagopyrum tataricum root, olibanum, draconis sanguis, fructus crataegi, synthetic musk and zingiberis rhizoma are put into a container, liquor is poured into the container, the container stands still in a shade place for 37 days after being sealed, filtering is performed after soaking is performed for 37 days, borneol is put in, standing still is then carried out for 9 days, finally, filtering is carried out, and the obtained solutionis filled into a medicinal spray container. The sublingual thrombolytic anti-bacterial spray has the beneficial effects that thrombus can be dissolved, blood fat can be reduced, cerebral infarction,myocardial infarction, arteriosclerosis, hemiplegia and the like can be prevented, an oral medicine spraying mode is adopted, the effect is faster and better than that of an oral medicine for sublingual affected parts, the spray is sprayed to sublingual Jinjin and Yuye acupoints, thrombus and blood garbage can be effectively dissolved, and the conditions of cerebral infarction, myocardial infarction, hemiplegia, facial paralysis, unclear speaking, dizzy and the like are prevented.

The invention discloses a fracture-setting and ache-removing traditional Chinese medicine as well as a preparation method and application thereof, and relates to the technical field of traditional Chinese medicinal compositions. The fracture-setting and ache-removing traditional Chinese medicine is prepared from the following raw materials by weight: 100 to 120 parts of woodlouse, 55 to 60 parts of olibanum, 55 to 60 parts of myrrh, 5 to 10 parts of synthetic musk, 5 to 10 parts of borneol, 80 to 85 parts of salviae miltiorrhizae, 30 to 35 parts of phryma leptostachya, 15 to 25 parts of ligusticum wallichii, 45 to 50 parts of angelica sinensis, 15 to 25 parts of divaricate saposhnikovia root, 55 to 60 parts of panax notoginseng, 30 to 35 parts of agilawood, 15 to 60 parts of plant soots, 55 to 75 parts of elm root barks, 55 to 65 parts of resina draconis, 30 to 35 parts of pangolin and 40 to 60 parts of liquorice. The fracture-setting and ache-removing traditional Chinese medicine is a traditional Chinese medicinal preparation for external application, and is prepared according to a conventional traditional Chinese medicine preparation method. The traditional Chinese medicine disclosed by the invention is outstanding in treating effect and high in curing rate, and has no toxic or side effects; the operating method is simple, and the traditional Chinese medicine can be used for treating different types of fractures and other ache diseases in different ages.

The invention discloses an external-use ointment for treating rhinitis. The external-use ointment comprises, by weight, 10-15 parts of chrysanthemum, 6-10 parts of bufonis venenum, 2-4 parts of synthetic musk, 4-6 parts of asarum, 6-8 parts of flos magnolia, 3-4 parts of radix angelicae dahuricae, 2-4 parts of fructus xanthii, 6-8 parts of radix aucklandiae, 4-5 parts of stir-fried radix scutellariae, 2-4 parts of semen brassicae, 7-9 parts of cantharides, 8-10 parts of rubia cordifolia root, 3-5 parts of prepared ephedra, 4-5 parts of centipeda minima, 6-8 parts of flos lablab, 8-10 parts of mirabilitum dehydratum, 2-4 parts of prepared myrrh, 3-4 parts of spina gleditsiae, 5-7 parts of periostracum cicada, 3-4 parts of vicia hirsuta and 2-3 parts of sedum drymarioides hance. The external-use ointment has the advantages that the external-use ointment is reasonable in prescription, the medicinal materials are safe and reliable and reasonably and scientifically combined to achieve effects of detoxifying with pungent and warm medicinal materials, diminishing inflammation and relieving pain, inducing resuscitation and eliminating nasal discharge, the external-use ointment can effectively treat allergic rhinitis, and the clinical treatment and observation of over 100 patients with the allergic rhinitis show that the effective rate of the external-use ointment reaches 98.8%.

The invention relates to ointment for treating skin ulceration, burns and scalds. The ointment is prepared from raw materials in parts by weight as follows: 1 part of synthetic musk, 10 parts of pearls, 10 parts of frankincense, 5 parts of crocus sativus, 1 part of borneol, 20 parts of dragon bone, 5 parts of fritillaria cirrhosa, 20 parts of talc, 10 parts of myrrh, 10 parts of dragon's blood, 5parts of cortex phellodendri amurensis, 5 parts of semen strychni, 5 parts of raw rhizoma arisaematis and 5 parts of elephant hide. Various common wounds can be treated and cured, the ointment has wide application range, can rapidly promote growth of wound granulation of long-term unhealed deep skin tissue ulcer, is high in wound healing speed and cure rate and is convenient to apply, healed epidermis is soft and good in elasticity, the scar remaining rate is low and the medicine changing pain is small.

The invention relates to a medicine composition for treating coronary heart disease and angina and a preparation method thereof. 500g of medicine composition is characterized by comprising the following components: 39g of ginseng stem and leaf total saponins, 16g of ox-gall cream powder, 30g of synthetic musk, 187g of pearl, 30g of calculus bovis factitious, 60g of borneol, 32.5g of venenum bufonis, 35.1g of pseudo-ginseng cream powder, and 70.4g of starch. The preparation method comprises steps of smashing, sieving, drawing, pelletizing, and drying at low temperature. The medicine composition is safe and efficient, can take effect rapidly, has low cost, is convenient to prepare, can be used for curing both coronary heart disease and angina, not only can be used for clinical rescue, but also achieves the purpose of healing.

The invention discloses a method for removing synthetic musk in water. The method for removing synthetic musk in water comprises the following steps: introducing sewage containing synthetic musk intoan aerobic hydrolysis-MBR membrane bioreactor for treatment; introducing the treated sewage into a reaction tank, adding a proper amount of active carbon, stirring and adsorbing for 24-36h, standing and precipitating for 40-60 min, and obtaining a clear liquid, namely treated sewage. The method for removing synthetic musk in water has advantages of short treatment time, obvious treatment effect and low treatment cost.

The invention discloses an ultrafine calcium preparation with effects of inhibiting bacteria, relieving itching and dispelling dampness and an application of the ultrafine calcium preparation. The traditional Chinese medicine composition, namely, the ultrafine calcium preparation comprises raw materials in parts by mass as follows: 15-20 parts of incised notopterygium rhizome, 10-20 parts of baical skullcap root, 5-12 parts of Polyporus umbellatus, 5-12 parts of oriental waterplantain rhizome, 3-6 parts of wasabi, 6-10 parts of divaricate saposhnikovia root, 5-12 parts of largetrifoliolious bugbane rhizome, 9-20 parts of kudzuvine root, 3-6 parts of frankincense, 1-3 parts of synthetic musk, 1-3 parts of alum, 2-6 parts of ultrafine calcium and 1-3 parts of liquorice root. The ultrafine calcium preparation with the effects of inhibiting bacteria, relieving itching and dispelling dampness can effectively remove dampness and toxins, promote pus stopping and healing of a wound surface, remove necrotic tissue, promote granulation and repair and protect regenerated cells and epidermis while killing bacteria and diminishing inflammation, has the functions of inhibiting bacteria, relieving itching and dispelling dampness aiming at feet and can effectively relieve symptoms such as skin itching and the like caused by mosquito bites and toxins, and the traditional Chinese medicine composition can be further used for mould control, bacteria killing, odor removal and the like by means of the strong antibacterial activity.

The invention relates to the identification of OR5A2 as an Olfactory Receptor that binds natural musk and synthetic musks. The invention encompasses the use of the interaction of OR5A2 polypeptides and nitromusk, polycyclic musk, macrocyclic musk and alicyclic musks as the basis of screening assays for agents that specifically modulate the activity of the OR of the invention.

The invention belongs to the technical field of natural product synthesis, and discloses a novel method for synthesizing musk extract (2R, 5R)-Musclide-A1. The method comprises the steps: utilizing cyclopropane-aminoalcohol chiral ligand / zinc to catalyze an addition reaction of methylacrolein 1 and (R)-3-benzyloxy-1-butyne 2 so as to obtain a compound 3, then performing reduction and sulfonation so as to obtain a compound 4, and finally performing deprotection so as to obtain the target compound (2R, 5R)-Musclide-A1. The method has the advantages of a simple synthetic route, mild reaction conditions, environmental friendliness and the like.

The invention provides a device for removing synthetic musk in sewage. The device comprises an aerobic treatment device and a sedimentation device, wherein the aerobic treatment device comprises a plurality of small microbial spheres arranged in the aerobic treatment device, a plurality of baffles vertically arranged in the aerobic treatment device, an aeration device located at the bottom of the aerobic treatment device as well as a carrier separator and an effluent weir which are located at a water outlet of the aerobic treatment device. Under the action of aeration and blockage with the baffles, the sewage sequentially passes through bottom ends and top ends of the adjacent baffles to form baffling flow which reciprocates up and down, and contact time with the plurality of small microbial spheres is prolonged; the small microbial spheres are spheres containing bacillus subtilis and a curing embedding agent, the curing embedding agent is used for adsorbing the synthetic musk in the sewage, and the bacillus subtilis is used for degrading the adsorbed synthetic musk; the degraded sewage is subjected to sedimentation treatment in the sedimentation device, and a supernatant is treated effluent.

The invention provides a traditional Chinese medicinal composition for treating liver tumor. The traditional Chinese medicinal composition is characterized by comprising the following raw medicinal materials in parts by weight: 15-40 parts of roots of turnip, 5-30 parts of trogopterus dung, 5-30 parts of rhizoma acori tatarinowii, 1-20 parts of stigma croci, 10-40 parts of fructus chebulae, 1-25 parts of thalli of usnea longissima, 0.5-5 parts of pericarpium zanthoxyli, 5-32 parts of semen brassicae, 1-30 parts of herba oxytropis, and at least one selected from 1-15 parts of cordyceps sinensis, 1-20 parts of semen entadae phaseoloidis, 0.1-5 parts of synthetic musk, 1-30 parts of herba rhodiolae sacrae, 1-20 parts of radix et rhizoma rhei, and 1-10 parts of herba hydrocotylis. The traditional Chinese medicinal composition can effectively inhibit the growth of the tumor of liver cancer patients and improve the life quality of the patients.

The invention discloses novel antioxidative rubber. The novel antioxidative rubber is prepared from, by weight, 50-70 parts of natural rubber, 10-30 parts of ethylene propylene diene monomer rubber, 6-10 parts of petroleum resin, 1-3 parts of propionyl phosphate bis-octadeca-ester, 1-3 parts of palmitamide, 1-3 parts of methyl propionate, 2-4 parts of p-phenylenediamine, 0.2-0.4 part of synthetic musk, 0.2-0.4 part of salicylic acid, 10-30 parts of argil, 3-5 parts of aromatic hydrocarbon oil, 1-3 parts of microcrystalline cellulose, 2-6 parts of microcrystalline wax, 6-10 parts of sulphur, 2-7 parts of titanium dioxide, 0.2-0.4 part of vitamin E, 1-3 parts of sodium citrate, 1-3 parts of limonene, 1-3 parts of benzoylacetone, 2-7 parts of tin antimony oxide, 2-7 parts of rare earth, 5-9 parts of silicon carbide, 6-8 parts of diamond micropowder, 20-30 parts of high-wear-resistant carbon black, 1-3 parts of stearic acid, 6-10 parts of nano-calcium carbonate, 2-4 parts of a coupling agent, 1-3 parts of an antioxidant and 2-4 parts of an anti-aging agent. The rubber has the very good wear resistance, corrosion resistance and aging resistance and especially has the significant oxidation resistance.

The invention provides a rhizoma gastrodiae powder for treating small animal infantile convulsions and a preparation method thereof. The rhizoma gastrodiae powder is prepared from, by weight, 80-120 parts of rhizoma gastrodiae, 80-120 parts of calculus bovis factitius, 160-240 parts of cornu bubali, 22-30 parts of synthetic musk, 40-60 parts of pearl, 80-120 parts of realgar, 80-120 parts of cinnabar, 80-120 parts of rhizoma coptidis, 80-120 parts of radix scutellariae, 80-120 parts of radix curcumae, 80-120 parts of fructus gardeniae, 80-120 parts of radix isatidis, 22-30 parts of borneol and80-120 parts of licorice root. The rhizoma gastrodiae powder for treating small animal infantile convulsions has a significant effect on the small animal infantile convulsions and has little toxic and side effects, in clinical treatment, after symptoms disappear, the medicine is usually continued to be given for 2-3 weeks for consolidating the effects, and no side effect appears.