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Method for determining synthetic musk concentration of breast milk

A technology for synthesizing musk and concentration, applied in the field of physical and chemical analysis and determination of organic chemical substances

Inactive Publication Date: 2008-12-31
SHANGHAI UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] At present, the research on the synthetic musk in the human body is still in its infancy in my country, and there is no document that has clearly published the method for the determination of the synthetic musk in breast milk. Influence has a positive meaning

Method used

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  • Method for determining synthetic musk concentration of breast milk
  • Method for determining synthetic musk concentration of breast milk
  • Method for determining synthetic musk concentration of breast milk

Examples

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Embodiment 1

[0036] In the present embodiment, the process and steps of assay method are as follows:

[0037] 1. Liquid-liquid extraction and constant weight fat

[0038] Measure 5ml of breast milk sample into a separatory funnel, add 0.01μg of recovery rate indicator D10-phenanthrene, then add 8ml of 8% potassium oxalate and 10ml of ethanol and shake well, then add 5ml of diethyl ether for shaking, and dissolve the mixture Carry out liquid-liquid extraction; first add 20ml of n-hexane, fully oscillate, let it stand for stratification, and separate the liquid after the liquid level is stratified, take the supernatant and pour it into a chicken heart bottle for later use; the collected lower turbid liquid Pour it into the separatory funnel again, add 10ml of n-hexane, oscillate fully, let it stand for stratification, take the supernatant and pour it into the original chicken heart bottle; Discard the turbid liquid in the lower layer; place the clarified liquid collected in the original chi...

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Abstract

The invention relates to a method which can stably detect the concentration of synthetic musk in breast milk, and the purpose of measuring the concentration of the synthetic musk in the breast milk is achieved through the combined method of the gel chromatographic column chemical pretreatment method and the gas chromatography-mass spectroscopy. The method belongs to the technical field of physical and chemical analysis and measurement of organic chemical materials. The pretreatment process of the breast milk in the method of the invention comprises liquid-liquid extraction and the step of passing through the gel chromatographic column, the solution after the concentration by eluting solution is processed by passing through a small silica gel column and finally enters a gas chromatograph-mass spectrograph (GC-MS) for carrying out the detection, thereby obtaining a mass spectrum curve diagram containing various synthetic musk in the breast milk sample and then utilizing the specific formula for calculating the content of the musk contained in the breast milk. The method of the invention is an effective measurement method which is stable and has higher accuracy.

Description

technical field [0001] The invention relates to a method capable of stably detecting the concentration of synthetic musk in breast milk. The purpose of measuring the concentration of synthetic musk in breast milk is achieved through a chemical pretreatment method of a gel chromatographic column and a method combining gas chromatography and mass spectrometry. The invention belongs to the technical field of physical and chemical analysis and measurement of organic chemical substances. Background technique [0002] As a synthetic organic compound, synthetic musk has replaced natural musk with its elegant aroma, excellent fragrance-fixing ability and low price. One of the main components in the industry. China is one of the largest producers of synthetic musk in the world. It has been developing synthetic musk since the 1970s. It was approved by the Ministry of Health as a new drug in 1993 and trial production was carried out. By the end of 2000, thousands of kilograms had been...

Claims

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Application Information

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IPC IPC(8): G01N30/88G01N30/08G01N30/12G01N27/64
Inventor 张晓岚梁高锋王珺郭亚文周静
Owner SHANGHAI UNIV
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