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Chemical sensor arrays with multiple sensors per well

A chemical sensor, chemical sensitive technology, applied in the sensor field of chemical analysis

Active Publication Date: 2019-12-20
LIFE TECH CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] A problem that arises in the operation of large chemical sensor arrays is the sensitivity of the sensor output signal to noise

Method used

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  • Chemical sensor arrays with multiple sensors per well
  • Chemical sensor arrays with multiple sensors per well
  • Chemical sensor arrays with multiple sensors per well

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Embodiment Construction

[0022] A chemical detection device is described comprising a plurality of chemical sensors for parallel detection of chemical reactions in the same operatively associated reaction zones. The multiple sensors can provide redundancy and improved accuracy in detecting properties of chemical reactions.

[0023] By utilizing multiple chemical sensors to separately detect the same chemical reaction, the individual output signals can be combined or processed to produce a composite low noise output signal. For example, individual output signals may be averaged such that the signal-to-noise ratio (SNR) of the composite output signal is improved by as much as the square root of the number of individual output signals. Additionally, the composite output signal can compensate for differences between the values ​​of the individual output signals caused by changes in chemical sensor performance that would otherwise complicate downstream signal processing. Thanks to the techniques described...

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Abstract

A device comprising a material defining a reaction zone. The device includes a plurality of chemically sensitive field effect transistors (chemFETs), each having a common floating gate (370) in communication with the reaction region. The device also includes circuitry to obtain respective output signals from the chemically sensitive field effect transistor indicative of an analyte within the reaction zone.

Description

[0001] Related applications [0002] This application claims priority to US Provisional Application No. 61 / 833,375, filed June 10, 2013, which is incorporated herein by reference. technical field [0003] The present invention relates to sensors for chemical analysis and to methods for manufacturing such sensors. Background technique [0004] Various types of chemical sensors have been used in the detection of chemical processes. One type is the chemically sensitive field effect transistor (chemFET). A chemFET contains a source and drain separated by a channel region and a chemically sensitive region coupled to the channel region. The operation of a chemFET is based on the modulation of the channel conductance caused by changes in charge at the sensitive region due to chemical reactions occurring nearby. Modulation of the channel conductance changes the chemFET's threshold voltage, which can be measured to detect and / or characterize a chemical reaction. Threshold voltag...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/414
CPCG01N27/414G01N27/4148G01N27/4145C12Q1/6874H01L29/66825
Inventor J.罗斯伯格K.菲费J.布斯蒂洛J.奥文斯
Owner LIFE TECH CORP
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