Thiourea compounds
A compound, thiourea technology, applied in the preparation of organic compounds, active ingredients of heterocyclic compounds, organic chemistry, etc., can solve problems such as low success rate, high price, and low patient acceptance
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Embodiment 1
[0083] Example 1, preparation of compound 1: 1-(3-(5-phenylpentyloxy)phenyl)thiourea (1-(3-(5-phenylpentyloxy)phenyl)thiourea)
[0084]
[0085] First, 1.2 g of potassium carbonate (8.7 mmol) was added to a stirred mixture consisting of 0.8 g of 3-nitrophenol (5.8 mmol), 1.32 g of (5-bromo-pentyl)-benzene (5.8 mmol), 0.96 g of potassium iodide (5.8 mmol) and 15 ml of N-methylpyrrolidone in a suspension. The above mixture was stirred at 90°C for 4 hours. After the reaction mixture was cooled to room temperature, 30 mL of water was added to terminate the reaction, and then extracted with ethyl acetate (30 mL×3). The combined organic phases were washed with brine and concentrated under vacuum. After the obtained residue was subjected to silica gel column chromatography, 1.4 g of 1-nitro-3-(5-phenylpentyloxy)benzene (4.93 mmol, yield 85%) was obtained as a colorless oil.
[0086] 5.57 g of tin(II) chloride (24.7 mmol) was added to a solution consisting of 1.4 g of 1-nitro-3-...
Embodiment 2
[0088] Example 2, preparation of compound 2: 1-(3-(4-phenylbutoxy)phenyl)thiourea (1-(3-(4-phenylbutoxy)phenyl)thiourea)
[0089] Its preparation method is similar to Example 1. EI-MS (M+1): 301
Embodiment 3
[0090] Example 3, preparation of compound 3: 1-(3-(3-phenylpropoxy)phenyl)thiourea (1-(3-(3-phenylpropoxy)phenyl)thiourea)
[0091] Its preparation method is similar to Example 1. EI-MS (M+1): 287
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