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Traditional Chinese medicine composition for preventing and treating pancreatic fibrosis and application thereof

A technology of pancreatic fibrosis and composition, which is applied in the field of traditional Chinese medicine composition for preventing and treating pancreatic fibrosis, can solve the problem of less application of pancreatic fibrosis, achieve the effects of cheap raw materials, simple preparation, and broad market prospects

Inactive Publication Date: 2016-06-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there are few reports on the application of traditional Chinese medicine compound prescriptions in the prevention and treatment of pancreatic fibrosis. Only the Chinese patent application CN201510218207.0, the application publication number is CN104825812A, discloses the application of a Chinese medicine composition in the preparation of drugs for the prevention or treatment of pancreatic fibrosis. The traditional Chinese medicine composition is 18 parts of wolfberry grass, 12 parts of heather vine, 12 parts of purple larkspur, 15 parts of pig's long ginseng, and 20 parts of wild gooseberry

Method used

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  • Traditional Chinese medicine composition for preventing and treating pancreatic fibrosis and application thereof
  • Traditional Chinese medicine composition for preventing and treating pancreatic fibrosis and application thereof
  • Traditional Chinese medicine composition for preventing and treating pancreatic fibrosis and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1: The effect of the traditional Chinese medicine compound of the present invention on pancreatic fibrosis rats

[0050] 1. Laboratory animals

[0051] 32 Wistar rats aged 12 weeks, male, 270-290g, purchased from Institute of Zoology, Chinese Academy of Sciences (experimental animal license number SCXK (Shanghai) 2007-0005), breeding conditions: constant temperature 25℃±0.5℃, relative humidity 40% -60%, constant light conditions (light hours from 7 am to 7 pm), reared under clean conditions, eat and water normally.

[0052] 2. Experimental drugs

[0053] Experimental drugs: 60 parts of Pinellia, 60 parts of Southern Star, 45 parts of dried tangerine peel, 45 parts of Poria, 45 parts of Gallus gallus domesticus, 30 parts of Zedoary Turmeric, 15 parts of Roasted Licorice; hereinafter referred to as "Chinese medicine group".

[0054] The specific preparation method is as follows: Weigh 60g of Pinellia ternata, 60g of Southern Star, 45g of dried tangerine peel, 45g of Poria,...

Embodiment 2

[0093] Example 2: Study on the effect of the Chinese medicine compound preparation of the present invention on pancreatic fibrosis factors

[0094] 1. Experimental animals: the same as in Example 1.

[0095] 2. Experimental drugs:

[0096] The experimental drug is the traditional Chinese medicine compound preparation of the present invention, which is the same as in Example 1;

[0097] The positive control drug is pancreatin enteric-coated capsules, the same as in Example 1.

[0098] 3. Experimental reagents and equipment: the same as in Example 1.

[0099] 4. Experimental methods and results:

[0100] (1) Immunohistochemical detection of pancreatic laminin (LN) expression

[0101] LN is one of the important components of extracellular matrix. It is an excellent indicator of pancreatic fibrosis and has good reliability.

[0102] For the experimental method, please refer to the literature VogelmannR, RufD, WagnerM, et al.EffectsoffibrogenicmediatorsonthedevelopmentofpancreaticfibrosisinaTGF-...

Embodiment 3

[0125] Example 3: Study on the intervention of PSC cells by the traditional Chinese medicine compound preparation of the present invention

[0126] 1. Experimental cell: rat pancreatic stellate cell (PSC)

[0127] The cells are cultured in DMEM medium containing 10% FBS. The cell morphology is disordered before culture, and the cells are evenly distributed in a long spindle shape after culture. Figure 8 Shown.

[0128] 2. The experimental drug is a traditional Chinese medicine compound preparation prepared by the present invention, which is the same as in Example 1.

[0129] 3. Experimental methods and results

[0130] (1) Traditional Chinese medicine can inhibit the activation of Akt pathway and reduce the content of p-Akt

[0131] For the experimental method, please refer to the literature MickeyM.Martin, JessicaA. Buckenberger, JinmaiJiang, et al.

[0132] The results of this experiment are as Picture 9 As shown, the traditional Chinese medicine group can inhibit Akt protein phosphor...

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Abstract

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for preventing and treating pancreatic fibrosis and application thereof. The traditional Chinese medicine composition is mainly prepared from the following components in parts by weight: 10-60 parts of processed rhizoma pinelliae, 10-60 parts of processed rhizoma arisaematis, 5-60 parts of pericarpium citri reticulatae, 5-60 parts of poria cocos, 5-60 parts of endothelium corneum gigeriae galli, 1-30 parts of curcuma zedoary and the like. Cell experiments prove that the traditional Chinese medicine composition can be used for inhibiting PSC cell activation of rats and lowering to cause fibrosis factor expression; animal experiments prove that the composition can be used for improving the general condition of pancreatic fibrosis rats, increasing body weight, inhibiting expression of fibrosis promoting factors, improving anti-fibrosis factor expression and remarkably alleviating the pancreatic fibrosis degree of the rats; and clinical experiments prove that abdominal pain, diarrhea, dyspepsia and other symptoms caused by pancreatic fibrosis of patients can be quickly improved, and chronic pancreatitis and pancreatic fibrosis can be effectively treated. The traditional Chinese medicine compound preparation has the characteristics of no toxicity and long-term taking availability, and has a wide market prospect.

Description

Technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a traditional Chinese medicine composition for preventing and treating pancreatic fibrosis and its use. Background technique [0002] Pancreatic fibrosis is the main pathological manifestation of chronic pancreatitis. This dynamic pathological process can cause irreversible scar changes in the pancreatic parenchyma, often leading to the decline or loss of pancreatic internal and exocrine functions. Clinically it can be seen that patients have abdominal pain, diarrhea, indigestion and diabetes. And other performance. There are no effective drugs and methods for the treatment of pancreatic fibrosis. [0003] The most critical trigger point of pancreatic fibrosis is the activation of pancreatic stellate cells (PSC). Under normal circumstances, PSC is in a dormant state; but when cells are damaged and inflammatory substances accumulate, PSC is gradually activated to f...

Claims

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Application Information

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IPC IPC(8): A61K36/9066A61P1/18A23L33/105A61K35/57
CPCA61K35/57A61K36/076A61K36/484A61K36/752A61K36/8884A61K36/8888A61K36/9066A61K2300/00
Inventor 王丹
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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