A kind of method that manganese compound catalyzes oxidation pyridine compound to synthesize ketone

Abstract

The invention discloses a method for synthesizing ketones or aldehydes by catalyzing the oxidation of pyridine compounds by manganese compounds. Pyridine compounds containing substituents are used as reaction substrates, manganese compounds are used as catalysts, and water, tert-butanol, acetonitrile, ethyl acetate or One or more than two kinds of dichloromethane as solvent, peroxide as oxygen source, react at 25-50°C for 12-48 h, so that the C-H bond of pyridine side chain is oxidized into ketone or aldehyde in one step, and the reaction The crude product was processed to obtain the final product. The preparation method of the invention has mild reaction conditions, less catalyst consumption, high atom economy, simple operation, wide application range of substrates and industrial applicability.

Description

A kind of method that manganese compound catalyzes oxidation pyridine compound to synthesize ketone technical field The invention belongs to the field of organic chemical synthesis, and in particular relates to a method for synthesizing ketones by catalytically oxidizing pyridine compounds with manganese compounds. Background technique The direct oxidation of C-H bonds to ketones or aldehydes is widely used in the fields of chemical industry and organic synthesis. However, the excess catalyst and high temperature and pressure reaction conditions limit its large-scale industrial application. There are not many reports on C–H bond oxidation reactions using catalytic amounts of transition metal catalysts and under mild conditions. Pyridine is a π-deficient heterocyclic ring, and its analogs are prone to reduction reactions, but difficult to undergo oxidation reactions. Therefore, the method of transition metal-catalyzed one-step oxidation of pyridine side chain C-H bonds to ...

AI Technical Summary

Problems solved by technology

The method is complicated to operate, the amount of catalyst is large, the reaction temperature is high, and acid needs to be added, so it is difficult to realize industrial application