Method for determining tobacco-specific N-nitrosamine and polycyclic aromatic hydrocarbons in mainstream smoke of cigarettes simultaneously

Abstract

The invention belongs to the technical field of chemical tests on cigarette smoke and particularly discloses a method for determining tobacco-specific N-nitrosamine and polycyclic aromatic hydrocarbons in mainstream smoke of cigarettes simultaneously. According to the method, a smoking machine smokes cigarettes, a Cambridge filter traps the mainstream smoke of the cigarettes, the filter is filtered by solutions containing interior labels, and an extraction solution is directly detected by an on-line gel chromatography-gas chromatography-tandem mass spectrometer after being filtered. Compared with a standard method, the method has the advantages that two compounds are determined together and the test efficiency is improved; all that is need for detection is to filter the smoke extraction solution, so that the method is convenient to operate, quick and efficient; the on-line gel chromatography-gas chromatography-tandem mass spectrometer is used for detection, and thus the automation degree is high and organic solvent consumption is low.

Description

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AI Technical Summary

Benefits of technology

This patented describes an improved testing technique that involves processing samples extracted by burning cigarettes with different types of nicotine or other chemical substances found on them. These techniques use specific molecules called ninitrosoaminets (NTA) which are small compounds made up mostly amino acids). By measuring these levels during smoking, researchers have been able to identify potential health hazards associated with exposure to harmful materials such as certain pesticides.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving testing accuracy during the development of new drugs or chemical compounds used in industry due to the complexity involved with analyzing them through various techniques such as gaschromatographic separation and ion mobility spectroscopy.

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