Method for determining tobacco-specific N-nitrosamine and polycyclic aromatic hydrocarbons in mainstream smoke of cigarettes simultaneously

A technology for cigarette mainstream smoke and polycyclic aromatic hydrocarbons, which is applied in the field of chemical testing of cigarette smoke, can solve the problems of instrument analysis conditions and parameter differences, and achieve the effects of simple operation, high test throughput, and high degree of automation

Active Publication Date: 2016-06-15
CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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Benefits of technology

This patented describes an improved testing technique that involves processing samples extracted by burning cigarettes with different types of nicotine or other chemical substances found on them. These techniques use specific molecules called ninitrosoaminets (NTA) which are small compounds made up mostly amino acids). By measuring these levels during smoking, researchers have been able to identify potential health hazards associated with exposure to harmful materials such as certain pesticides.

Problems solved by technology

This patented technical problem addressed in this patents relates to improving testing accuracy during the development of new drugs or chemical compounds used in industry due to the complexity involved with analyzing them through various techniques such as gaschromatographic separation and ion mobility spectroscopy.

Method used

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  • Method for determining tobacco-specific N-nitrosamine and polycyclic aromatic hydrocarbons in mainstream smoke of cigarettes simultaneously
  • Method for determining tobacco-specific N-nitrosamine and polycyclic aromatic hydrocarbons in mainstream smoke of cigarettes simultaneously
  • Method for determining tobacco-specific N-nitrosamine and polycyclic aromatic hydrocarbons in mainstream smoke of cigarettes simultaneously

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Embodiment 1

[0019] A method for measuring tobacco-specific N-nitrosamines and polycyclic aromatic hydrocarbons in mainstream smoke of cigarettes, the specific steps of operation are:

[0020]The first step is the preparation of standard series solutions: using ethyl acetate and acetone with a volume ratio of 1:1 as solvents, four tobacco-specific N-nitrosamines (NAB, NAT, NNN and NNK) and three polycyclic aromatic hydrocarbons (BaP, BaA, and Chry) standard products are solutes, NAB-d4, NAT-d4, NNN-d4, NNK-d4, and BaP-d12 are internal standards, and standard series solutions containing internal standards with different concentrations are prepared;

[0021] The second step, the preparation of the sample solution: smoke the balanced and screened cigarettes with a linear smoking machine according to the standard conditions specified in GB / T19609-2004, ISO4387:2000, and smoke 5 cigarettes for each experiment. Put the filter that has captured the total particle phase of mainstream smoke into a ...

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Abstract

The invention belongs to the technical field of chemical tests on cigarette smoke and particularly discloses a method for determining tobacco-specific N-nitrosamine and polycyclic aromatic hydrocarbons in mainstream smoke of cigarettes simultaneously. According to the method, a smoking machine smokes cigarettes, a Cambridge filter traps the mainstream smoke of the cigarettes, the filter is filtered by solutions containing interior labels, and an extraction solution is directly detected by an on-line gel chromatography-gas chromatography-tandem mass spectrometer after being filtered. Compared with a standard method, the method has the advantages that two compounds are determined together and the test efficiency is improved; all that is need for detection is to filter the smoke extraction solution, so that the method is convenient to operate, quick and efficient; the on-line gel chromatography-gas chromatography-tandem mass spectrometer is used for detection, and thus the automation degree is high and organic solvent consumption is low.

Description

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Claims

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Application Information

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Owner CHINA NAT TOBACCO QUALITY SUPERVISION & TEST CENT
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