Preparation method and application of high-amoxicillin-content soluble powder

A soluble powder, amoxicillin technology, applied in powder delivery, pharmaceutical formulations, medical preparations with non-active ingredients, etc., can solve the problems of easy agglomeration, discoloration, affecting use and efficacy, etc.

Active Publication Date: 2016-07-06
RINGPU TIANJIN BIOLOGICAL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, amoxicillin has poor solubility, slightly bitter taste, and low bioavailability
At present, the content of amoxicillin is mainly 10%. Due to the low concentration, poor stability, agglomeration and discoloration are easy to occur, and the shelf life is short,

Method used

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  • Preparation method and application of high-amoxicillin-content soluble powder
  • Preparation method and application of high-amoxicillin-content soluble powder
  • Preparation method and application of high-amoxicillin-content soluble powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017]

[0018] Preparation method: crush amoxicillin, sodium citrate, sodium dihydrogen phosphate, sodium alginate, and lactose in the prescribed amount and pass through an 80-mesh sieve. Granulate with a mesh sieve and dry at 60°C to obtain a high-content amoxicillin soluble powder.

Embodiment 2

[0020]

[0021]

[0022] Preparation method: Grind amoxicillin, sodium citrate, sodium dihydrogen phosphate, sodium alginate and lactose in the formula and pass through a 80-mesh sieve, mix evenly, add 75% ethanol and mix to make a soft material, pass through a 50-mesh sieve Granulate and dry at 60°C to obtain high-content amoxicillin soluble powder.

Embodiment 3

[0024]

[0025] Preparation method: Grind amoxicillin, sodium citrate, sodium dihydrogen phosphate, sodium alginate, and lactose in the formula and pass through an 80-mesh sieve in sequence, after mixing evenly, add 75% ethanol and mix to make a soft material, pass through a 50-mesh sieve Sieve and granulate, and dry at 60°C to obtain high-content amoxicillin soluble powder.

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PUM

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Abstract

The invention relates to high-amoxicillin-content soluble powder, and a preparation method and application thereof, and belongs to the field of a veterinary drug. The problem that an amoxicillin aqueous solution is low in dissolvability and poor in stability, which affects a therapeutic effect and application of the amoxicillin aqueous solution is solved. The powder comprises amoxicillin, a co-solvent, a stabilizing agent, a corrigent, and a soluble filler, and is used for treating porcine intestinal and respiratory tract infection due to bacteria such as escherichia coli and salmonella.

Description

Technical field: [0001] The invention belongs to the field of veterinary medicine, and relates to a high-content amoxicillin soluble powder, a preparation method and an application. Background technique: [0002] Amoxicillin, also known as amoxicillin, was first introduced to the market by BEECHAM in 1968. It is a semi-synthetic β-lactam antibiotic. Due to the β-lactam ring in its molecule Unstable, vulnerable to nucleophilic and electrophilic attacks, under the action of acids, alkalis, certain metal ions and oxidants, the β-lactam ring can be opened and molecular rearrangement can occur. Amoxicillin has a strong effect on Gram-negative bacteria such as Neisseria gonorrhoeae, influenza bacillus, pertussis bacilli, Escherichia coli, Brucella, etc., and is mainly used for infections of the urinary system, respiratory system, and biliary tract in human clinical practice. [0003] Amoxicillin is currently mainly used to treat poultry colibacillosis, salmonellosis, pasteurellos...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K31/43A61K47/36A61K47/26A61P31/04A61P1/00A61P11/00
Inventor 吕晓静孟小宾张晓鹏
Owner RINGPU TIANJIN BIOLOGICAL PHARMA
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