Method and device for constructing biological information database

Abstract

The invention discloses a method and device for constructing a biological information database. The method comprises the steps that according to a disease list, reference abstract resources related to a disease name are acquired from a network; each reference abstract is decomposed, so that abstract information containing abstract contents is acquired; gene and mutation information in the abstract contents is extracted and classified according to a gene list and a mutation regular expression semantic database, and classified results of each type are filtered and / or noted in combination with human genome reference sequences; a related word semantic database corresponding to the disease is established, and a gene mutation score is determined according to the related word semantic database; and data obtained at previous steps is arranged, and the biological information database is established. The method and device disclosed by the invention are characterized in that a biomedicine reference database is excavated by a text excavation algorithm, and mutation information and relations related to the disease are extracted from the database, so that the biological information database especially a human disease outbreak database which is based on research fronts, has comprehensive and reliable data and can be updated rapidly can be established.

Description

technical field [0001] The invention relates to the field of biological information data, in particular to a method and device for constructing a biological information database, especially a human disease emergency database. Background technique [0002] The development of second-generation sequencing technology has brought life science into the genome era quickly. More and more evidence shows that the variation from the genome is the main cause of human diseases. For example, single nucleotide polymorphism (SNP, Single Nucleotide Polymorphism), which is the most common type of human heritable variation, accounting for more than 90% of all known polymorphisms, mainly refers to the single nucleotide polymorphism at the genome level. DNA sequence polymorphism caused by acid variation. SNP has become the third-generation genetic marker because of its large number, wide distribution, and suitability for rapid and large-scale screening. . In addition, there are various genom...

AI Technical Summary

Problems solved by technology

At the same time, due to the large amount of mutation information and the fast update speed, manual collection is not only costly and slow, but also has problems such as information omission and low reliability.

In these two aspects, the application of the above database is still insufficient

Moreover, due to problems such as charges in some databases, users are limited in obtaining the latest data

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