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Three-dimensional bionic nanometer material for capturing circulating tumor cells and preparation method thereof

A tumor cell, biomimetic nanotechnology, applied in nanotechnology for materials and surface science, tumor/cancer cells, animal cells, etc., can solve the problems of poor identification selectivity and low purity, reduce mis-selection and enhance cell The effect of adhesion, efficient identification and capture

Active Publication Date: 2016-07-20
上海揽微赛尔生物科技有限公司
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Problems solved by technology

In the application of the nano-dot and nano-wire array structures that have been used, the excellent characteristics of nano-structured materials have been verified, but there are still problems of poor recognition selectivity and low purity.

Method used

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  • Three-dimensional bionic nanometer material for capturing circulating tumor cells and preparation method thereof
  • Three-dimensional bionic nanometer material for capturing circulating tumor cells and preparation method thereof
  • Three-dimensional bionic nanometer material for capturing circulating tumor cells and preparation method thereof

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Embodiment Construction

[0026] The present invention will be described in further detail below in conjunction with the accompanying drawings and specific embodiments, but not as a limitation of the present invention.

[0027] The nanometer functional material with a three-dimensional structure of the invention can be used for the identification and effective capture of circulating tumor cells in peripheral blood samples. The whole structure is composed of three layers of materials, which are silicon base material 1, porous graphene 2, and silicon microspheres 3. The three materials are combined through a self-assembly process to form a complex three-dimensional array structure. After chemical modification, the E-selectin protein molecule 22 and the recognition ligand 32 for cell recognition can be immobilized on the surface of graphene and silicon microspheres respectively, so as to realize a biomimetic effect and improve the recognition ability of rare tumor cell objects , enhances adherent fixatio...

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Abstract

The invention provides a three-dimensional bionic nanometer material for capturing circulating tumor cells and a preparation method thereof.The material is composed of porous graphene, microballoon spheres and a silicon substrate, a three-dimensional array structure is formed through electrostatic adsorption and self-assembly, chemical modification is carried out on the surfaces of the graphene and the microballoon spheres, E-selectin protein molecules and ligands used for cell capturing are modified and fixed, and a bionic structure for enhancing cell recognition is achieved.The material can be integrated in a micro-fluidic chip, recognition and capturing of the chip for the circulating tumor cells is are enhanced, separation efficiency is improved, and the captured cells can be detected and analyzed conveniently; a fixed recognition ligand is changed, the material can also be used for effectively capturing different types of cells, and rare tumor cells can be recognized and captured from peripheral blood samples.

Description

【Technical field】 [0001] The invention relates to a nano functional material for processing peripheral blood cells, in particular to a three-dimensional bionic nano material for capturing circulating tumor cells and a preparation method thereof. 【Background technique】 [0002] Circulating tumor cells are tumor cells that fall off from the original tumor tissue and infiltrate into the blood circulation system, and circulate in the body with the blood. Although people still lack a clear understanding of the mechanism and process of cancer metastasis, the role of circulating tumor cells is directly related to cancer metastasis, which has been consistently confirmed. Therefore, the number and morphology of circulating tumor cells can be used as the basis for predicting the development of the patient's disease, such as the diagnosis of the disease, postoperative monitoring, pathological research, etc. However, it is very difficult to obtain tumor cells from peripheral blood samp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36C12N5/09B82Y30/00
CPCA61M1/362A61M1/3679C12N5/0693B82Y30/00A61M2207/00A61M2205/02
Inventor 王小章王朝晖张群明
Owner 上海揽微赛尔生物科技有限公司
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