A thermosensitive hydrogel for skin heat damage and preparation method thereof
A temperature-sensitive hydrogel and heat-damaged technology, applied in the field of beauty repair materials, can solve the problems of increasing the number of treatment steps, not fully satisfying the user, and not being reliable and comfortable for the user, so as to improve the cross-linking strength and forming ability, and improve skin nutrition Metabolism, the effect of improving water retention and replenishment ability
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Embodiment 1
[0041]Taking 100g as the total amount, weigh 2g chitosan, 2g sodium hyaluronate, 28.8g sodium glycerophosphate, 3.5mg genipin, 3.8×10 -2 ng human epidermal growth factor EGF, 50mg arbutin, 1g aloin, 0.5g menthol, and the rest is distilled water.
[0042] Step 1, at a constant temperature of 4°C, chitosan, sodium hyaluronate, sodium glycerophosphate and genipin are mixed and stirred to form a gel precursor mixture;
[0043] Step 2, add human epidermal growth factor EGF, arbutin, aloin, menthol and distilled water in sequence to the gel precursor mixture, stir evenly, and obtain a thermosensitive hydrogel for skin heat damage, and store it at 4°C condition.
[0044] The prepared temperature-sensitive hydrogel for skin thermal injury, which contains 0.02g / ml chitosan, 0.02g / ml sodium hyaluronate, 0.288g / ml sodium glycerophosphate, 0.035mg / ml Beijing Nepin, and 3.8×10 -4 ng / ml of human epidermal growth factor EGF, 0.5mg / ml of arbutin, 0.01g / ml of aloin, 5mg / ml of menthol, and t...
Embodiment 2
[0046] Taking 100g as the total amount, weigh 5g chitosan, 4g sodium hyaluronate, 50g sodium glycerophosphate, 6mg genipin, 5×10 -2 ng human epidermal growth factor EGF, 100mg arbutin, 2g aloin, 1g menthol, and the rest is distilled water.
[0047] Step 1, at a constant temperature of 4°C, chitosan, sodium hyaluronate, sodium glycerophosphate and genipin are mixed and stirred to form a gel precursor mixture;
[0048] Step 2, add human epidermal growth factor EGF, arbutin, aloin, menthol and distilled water in sequence to the gel precursor mixture, stir evenly, and obtain a thermosensitive hydrogel for skin heat damage, and store it at 4°C condition.
[0049] The prepared thermosensitive hydrogel for skin thermal injury, which contains 0.05g / ml chitosan, 0.04g / ml sodium hyaluronate, 0.5g / ml sodium glycerophosphate, 0.06mg / ml genipin, and 5×10 -4 ng / ml human epidermal growth factor EGF, 1mg / ml arbutin, 20mg / ml aloin, 10mg / ml menthol, the rest is distilled water.
Embodiment 3
[0051] Taking 100g as the total amount, weigh 1g chitosan, 0.5g sodium hyaluronate, 10g sodium glycerophosphate, 1mg genipin, 2×10 -2 ng human epidermal growth factor EGF, 0.5g arbutin, 50mg aloin, 50mg menthol, and the rest is distilled water.
[0052] Step 1, at a constant temperature of 4°C, chitosan, sodium hyaluronate, sodium glycerophosphate and genipin are mixed and stirred to form a gel precursor mixture;
[0053] Step 2, add human epidermal growth factor EGF, arbutin, aloin, menthol and distilled water in sequence to the gel precursor mixture, stir evenly, and obtain a thermosensitive hydrogel for skin heat damage, and store it at 4°C condition.
[0054] The prepared thermosensitive hydrogel for skin thermal injury, which contains 0.01g / ml chitosan, 5mg / ml sodium hyaluronate, 0.1g / ml sodium glycerophosphate, 0.01mg / ml genipin, and 2 ×10 -4 ng / ml human epidermal growth factor EGF, 5mg / ml arbutin, 0.5mg / ml aloin, 0.5mg / ml menthol, and the rest is distilled water.
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