Thermosensitive hydrogel for skin thermal damage and preparation method thereof

A temperature-sensitive hydrogel and heat-damaged technology, applied in the field of cosmetic repair materials, can solve the problems of increased treatment steps, short cooling duration, unreliable and comfortable users, etc., to improve cross-linking strength and forming ability, and improve continuous cooling ability , Improve the effect of water locking and replenishing ability

Inactive Publication Date: 2016-08-17
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current cold wet compress and 4°C pre-cooling mask can have a cooling effect within a few minutes to ten minutes after application, and the cooling effect is obvious only within a few minutes after use, and the cooling effect is greatly reduced over time, and the cooling continues. Time is short, unable to meet clinical requirements
[0007] (2) High liquid fluidity, poor water retention and replenishment
But this will increase the number of treatment steps and bring inconvenience to the user
[0009] (3) The usable area and location are limited
Existing products are mainly designed for facial skin, and thermal damage to the skin often occurs in other parts of life, such as: laser hair removal, armpit and other folds, irregular surface, poor affinity between the mask and the skin, and limited shape. It cannot meet the needs of various treatment positions and treatment areas, greatly reducing the operability
It cannot fully meet the needs of users, and cannot bring reliable and comfortable improvement effects to users.

Method used

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  • Thermosensitive hydrogel for skin thermal damage and preparation method thereof
  • Thermosensitive hydrogel for skin thermal damage and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041]Taking 100g as the total amount, weigh 2g chitosan, 2g sodium hyaluronate, 28.8g sodium glycerophosphate, 3.5mg genipin, 3.8×10 -2 ng human epidermal growth factor EGF, 50mg arbutin, 1g aloin, 0.5g menthol, and the rest is distilled water.

[0042] Step 1, at a constant temperature of 4°C, chitosan, sodium hyaluronate, sodium glycerophosphate and genipin are mixed and stirred to form a gel precursor mixture;

[0043] Step 2, add human epidermal growth factor EGF, arbutin, aloin, menthol and distilled water in sequence to the gel precursor mixture, stir evenly, and obtain a thermosensitive hydrogel for skin heat damage, and store it at 4°C condition.

[0044] The prepared temperature-sensitive hydrogel for skin thermal injury, which contains 0.02g / ml chitosan, 0.02g / ml sodium hyaluronate, 0.288g / ml sodium glycerophosphate, 0.035mg / ml Beijing Nepin, and 3.8×10 -4 ng / ml of human epidermal growth factor EGF, 0.5mg / ml of arbutin, 0.01g / ml of aloin, 5mg / ml of menthol, and t...

Embodiment 2

[0046] Taking 100g as the total amount, weigh 5g chitosan, 4g sodium hyaluronate, 50g sodium glycerophosphate, 6mg genipin, 5×10 -2 ng human epidermal growth factor EGF, 100mg arbutin, 2g aloin, 1g menthol, and the rest is distilled water.

[0047] Step 1, at a constant temperature of 4°C, chitosan, sodium hyaluronate, sodium glycerophosphate and genipin are mixed and stirred to form a gel precursor mixture;

[0048] Step 2, add human epidermal growth factor EGF, arbutin, aloin, menthol and distilled water in sequence to the gel precursor mixture, stir evenly, and obtain a thermosensitive hydrogel for skin heat damage, and store it at 4°C condition.

[0049] The prepared thermosensitive hydrogel for skin thermal injury, which contains 0.05g / ml chitosan, 0.04g / ml sodium hyaluronate, 0.5g / ml sodium glycerophosphate, 0.06mg / ml genipin, and 5×10 -4 ng / ml human epidermal growth factor EGF, 1mg / ml arbutin, 20mg / ml aloin, 10mg / ml menthol, the rest is distilled water.

Embodiment 3

[0051] Taking 100g as the total amount, weigh 1g chitosan, 0.5g sodium hyaluronate, 10g sodium glycerophosphate, 1mg genipin, 2×10 -2 ng human epidermal growth factor EGF, 0.5g arbutin, 50mg aloin, 50mg menthol, and the rest is distilled water.

[0052] Step 1, at a constant temperature of 4°C, chitosan, sodium hyaluronate, sodium glycerophosphate and genipin are mixed and stirred to form a gel precursor mixture;

[0053] Step 2, add human epidermal growth factor EGF, arbutin, aloin, menthol and distilled water in sequence to the gel precursor mixture, stir evenly, and obtain a thermosensitive hydrogel for skin heat damage, and store it at 4°C condition.

[0054] The prepared thermosensitive hydrogel for skin thermal injury, which contains 0.01g / ml chitosan, 5mg / ml sodium hyaluronate, 0.1g / ml sodium glycerophosphate, 0.01mg / ml genipin, and 2 ×10 -4 ng / ml human epidermal growth factor EGF, 5mg / ml arbutin, 0.5mg / ml aloin, 0.5mg / ml menthol, and the rest is distilled water.

...

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PUM

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Abstract

The invention relates to a cosmetic repair material, and specifically discloses a thermosensitive hydrogel for skin thermal damage and a preparation method thereof. The thermosensitive hydrogel comprises the following components: chitosan, sodium hyaluronate, genipin, arbutin, aloin, menthol, and the balance of distilled water. The preparation method is as below: first, mixing by stirring chitosan, hyaluronic acid and genipin at a constant temperature of 4 DEG C to form a gel precursor mixture; then, adding arbutin, aloin, menthol and distilled water in the gel precursor mixture, and stirring. The thermosensitive hydrogel has the following advantages: (1) continuous cooling; (2) good water lock and water supplement effect, and comfortable usage; (3) flexible use space and position; (4) good performances of improvement of inflammation response, burning, tightness, pain and discomfort, and promotion of skin repair.

Description

technical field [0001] The invention relates to a cosmetic repair material, in particular to a temperature-sensitive hydrogel for skin heat damage and a preparation method thereof. Background technique [0002] In daily life, almost everyone has experienced skin thermal damage (such as sunburn or non-selective thermal damage such as laser surgery). Among them, sunburn is the most common, often accompanied by symptoms such as diffuse bright red spots, tight discomfort, conscious burning or tingling sensation on the skin of the exposed part. Sunburn mainly adopts local therapy, which is based on the principles of cooling, hydrating, anti-inflammatory, appeasement, and pain relief. For sunburn, people often use wet towel cold compress or after-sun repair products (such as moisturizing, whitening, repairing mask) to improve discomfort symptoms. [0003] Thermal damage to the skin after laser cosmetic surgery is similar to sunburn and is the most common complication in the medi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/73A61K8/04A61K8/49A61K8/60A61K8/34A61K8/55A61K8/64A61Q19/00
CPCA61K8/042A61K8/34A61K8/498A61K8/55A61K8/602A61K8/64A61K8/735A61K8/736A61Q19/00
Inventor 孔亮秦东泽许珊珊齐亚平付乾梁建飞程兵坤郝英
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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