Crystal form B of anisodine hydromide and preparation method and application of crystal form B
A kind of technology of anisodine hydrobromide and crystal form, applied in the crystal form B of anisodine hydrobromide and the field of preparation and use, can solve the problem that no patent discloses the preparation method of anisodine hydrobromide crystal form, etc. problem, to achieve the effects of low cost, good stability, and simple operation of the preparation process
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[0052] Example 1
[0053] Preparation method of anisodine hydrobromide crystal form B:
[0054] Weigh 21.4 mg of anisodine hydrobromide solid, dissolve it in 0.3 mL of methanol, add 6.0 mL of anti-solvent ethyl acetate dropwise to it, and solid precipitate, centrifuge and dry. The solid was collected, and after testing, the obtained solid was crystal form B.
[0055] The X-ray powder diffraction data of the crystal form obtained in this example is shown in Table 1. Its XRPD diagram is like figure 1 , Its DSC graph is like figure 2 , The TGA diagram is as image 3 .
[0056] Table 1
[0057] 2theta
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[0058] Example 2
[0059] Preparation of anisodine hydrobromide crystal form B by anti-solvent addition method:
[0060] Weigh 9.6 mg of anisodine hydrobromide solid and dissolve it in 0.2 mL of methanol, add 3.0 mL of anti-solvent ethyl acetate dropwise to it, and solid precipitate, centrifuge and dry. The solid was collected, and after testing, the obtained solid was crystal form B.
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