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Examination indexes of SonoVue ultrasonic contrast technology in diagnosis and treatment of tumor angiogenesis mimicry

A tumor angiogenesis and contrast-enhanced ultrasound technology, which is applied in the field of clinical tumor vascular ultrasound examination, and can solve the problems of blank stage, inability to qualitatively distinguish between endothelial blood vessels and angiogenesis mimicry, and lack of SonoVue contrast-enhanced ultrasound technology.

Inactive Publication Date: 2016-08-24
JIANGNAN UNIV
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  • Application Information

AI Technical Summary

Problems solved by technology

At present, contrast-enhanced ultrasound can only evaluate the overall blood supply of tumor tissue, and cannot qualitatively distinguish and quantitatively analyze endothelial vessels and angiogenesis mimicry in tumor tissue, which largely limits the application of SonoVue contrast-enhanced ultrasound in tumor tissue. Development and application in benign and malignant diagnosis
[0006] After investigation, there is no relevant literature report on SonoVue contrast-enhanced ultrasound technology in the diagnosis and treatment of tumor angiogenesis mimicry (from CNKI, VIP China Journal Network), so this research field is still in a blank stage

Method used

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  • Examination indexes of SonoVue ultrasonic contrast technology in diagnosis and treatment of tumor angiogenesis mimicry
  • Examination indexes of SonoVue ultrasonic contrast technology in diagnosis and treatment of tumor angiogenesis mimicry
  • Examination indexes of SonoVue ultrasonic contrast technology in diagnosis and treatment of tumor angiogenesis mimicry

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Experimental program
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Embodiment 1

[0010] 1. Preparation of 1H22 tumor-derived mice

[0011] Take out the frozen mouse H22 cell line from the ultra-low temperature refrigerator at -80°C, thaw it quickly at a water bath temperature of 39°C, dilute the cell suspension with physiological saline under sterile conditions, count under an optical microscope, and adjust the cell concentration to 2×10 7 -4×10 7 individual / mL. Draw 0.3mL cell diluent with a 1mL syringe and inoculate into the peritoneal cavity of ICR mice, and raise them routinely to make H22 tumor-derived mice.

[0012] 1. Preparation of 2H22 tumor-bearing mouse model

[0013] After the H22 tumor-derived mice were bred for 7 days, the mice with obvious abdominal swelling were selected and sacrificed by neck dislocation. Tumor-derived mice with bloody ascites were excluded. Under aseptic conditions, use scissors to cut the abdominal skin of the mouse, cut a small hole in the peritoneum, and then use a 1 mL needle-free syringe to extract ascites, and p...

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Abstract

The invention discloses examination indexes of a SonoVue ultrasonic contrast technology in diagnosis and treatment of tumor angiogenesis mimicry and belongs to the technical field of clinical tumor vessel ultrasonic examination. The situation that ultrasonic examination indexes including the rising time, the time to peak and the average transition time can be used for clinical diagnosis and treatment of tumor angiogenesis mimicry is found for the first time, a basis is provided for clinical early noninvasive diagnosis of tumor angiogenesis mimicry, the grade malignancy, the blood supply mode and other characters of a tumor of a patient can be clinically diagnosed easily, and a diagnosis basis is provided for drug selection or operation treatment.

Description

Technical field: [0001] The invention belongs to the technical field of clinical tumor blood vessel ultrasonography, and relates to providing inspection indicators for early clinical non-invasive diagnosis of tumor angiogenesis mimicry, which is helpful for clinical diagnosis of tumor malignancy and blood supply mode characteristics of patients, and for drug selection or surgery. Treatment provides the basis for diagnosis. Background technique: [0002] Blood vessels play an important role in tumorigenesis and progression. Blood vessels not only provide oxygen and nutrients for tumor cells, carry away toxic metabolites, but also provide blood channels for tumor cell metastasis. Tumor blood vessel research began in 1971. Folkman first connected blood vessels with tumors, and proposed the theory of "anti-tumor blood vessel therapy" predictively. Since then, with the progress of basic tumor research, the classification of tumor vessels has become more refined, including: endo...

Claims

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Application Information

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IPC IPC(8): A61K49/22
CPCA61K49/223
Inventor 邱丽颖冯磊王旭蔡维维刘艳玲侯豹
Owner JIANGNAN UNIV
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