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Externally applied medicinal gel for treating onychomycosis and preparation method thereof

A technology for external application of medicine and gel, applied in the field of medicine, can solve the problems of easy recurrence, long treatment time, pain, etc., and achieve the effects of improving blood circulation, high cure rate and short course of treatment

Inactive Publication Date: 2016-08-31
郑州雷曼药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

You will feel more pain after the operation, and because the symptoms are not cured, the effect is not ideal, and it is easy to re-infect and recur
2. Oral drugs: taking antifungal drugs alone, such as fluconazole, griseofulvin, etc., has a certain effect, but because these drugs must reach the deck where the fungus parasitizes, they can exert antibacterial effects; and the dosage is large, Long medication time
However, the medicaments currently on the market not only take a long time to treat, but also are difficult to cure, and are prone to relapse after half a year.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The above-mentioned external drug gel for the treatment of onychomycosis preferably comprises the raw materials of following weight ratio:

[0021] Hibiscus bark extract 1g, flavescens extract 0.5g, ginger root extract 1g, povidone iodine 3g, acetylsalicylic acid 12g, hydroxyethyl cellulose 1.5g, absolute ethanol 38.95g, water 26g, acetic acid 0.05g, macrogol 400 15g and laurocapram 1g.

[0022] The preparation method of the external drug gel for the above-mentioned treatment of onychomycosis, it comprises the steps:

[0023] 1) Take each raw material in proportion, add absolute ethanol, polyethylene glycol 400, acetylsalicylic acid and povidone-iodine into the container, and stir evenly;

[0024] 2) Dissolve Hibiscus bark extract, Sophora flavescens extract and Ginger root extract respectively with appropriate amount of water, and then add them into the container;

[0025] 3) Add hydroxyethyl cellulose and the rest of the water, and stir well;

[0026] 4) Add acetic...

Embodiment 2

[0028] A kind of external medicine gel for the treatment of onychomycosis, it comprises the raw material of following weight ratio:

[0029] Hibiscus bark extract 2g, flavescens extract 0.5g, ginger root extract 2g, povidone iodine 2g, acetylsalicylic acid 10g, hydroxyethyl cellulose 2g, ethanol 40g, water 20.65g, acetic acid 0.05g, Macrogol 400 20g and laurocaprone 0.8g.

[0030] The preparation method of the above-mentioned external drug gel for treating onychomycosis can refer to Example 1.

Embodiment 3

[0032] A kind of external medicine gel for the treatment of onychomycosis, it comprises the raw material of following weight ratio:

[0033] Hibiscus bark extract 1g, flavescens extract 1.5g, ginger root extract 3g, povidone iodine 4g, acetylsalicylic acid 15g, hydroxyethyl cellulose 1g, ethanol 35g, water 27.95g, acetic acid 0.05g, Macrogol 400 10g and laurocaprone 1.5g.

[0034] The preparation method of the above-mentioned external drug gel for treating onychomycosis can refer to Example 1.

[0035] When used for the treatment of onychomycosis, first use a knife to scrape off the brittle nail surface or thin nails (with no pain or bleeding), and then apply an appropriate amount of the gel of the present invention evenly on the onychomycosis (about 2- 3mm thick), massage for a while to help absorption, 5-6 times a week, two weeks is a course of treatment, usually 2 to 8 courses of treatment can be cured. Notes are as follows:

[0036] 1) This product is for external use o...

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PUM

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Abstract

The invention relates to externally applied medicinal gel for treating onychomycosis. The gel is prepared from the following raw materials by weight: 0.5-3g of cortex pseudolaricis extract, 0.3-1.5g of radix flavescentis extract, 0.5-3g of ginger root extract, 2-5g of povidone iodine, 10-15g of acetylsalicylic acid, 1-2g of hydroxyethyl cellulose, 35-40g of ethanol, 20-30g of water, 0.03-0.07g of acetic acid, 10-20g of polyethylene glycol 400 and 0.5-1.5g of laurocapram. The externally applied medicinal gel can be used for quickly healing deformed, thickened, discolored, sunk and tarnished nails caused by candida albicans, staphylococcus aureus, escherichia coli and the like, has the advantages of quick response, short course of treatment and high cure rate, and has a total effective rate of 97.5 percent.

Description

Technical field [0001] The present invention is a drug technology field, which involves an external drug gel agent and its preparation methods that treat ash nails. Background technique [0002] The onychomycosis is a common dermatology. The medical name is "mooria". The cause is caused by fungal infection (toe) nails.After suffering from nailing, the nails gradually thickened and deformed, and the color occurred abnormally. It was yellowish or gray -black. There was no gloss that (toe) nails should have.The surface of the deck is uneven, and sometimes it is raised or bending downward, which is extremely ugly, affecting the appearance of the hands and feet, and damaging the image. [0003] At present, the treatment of onychomycosis is mostly divided into three categories: 1. Surgical armor: Under local anesthesia, the affected armor is removed.This method is large and bleeding, which is easy to cause infection.It will feel more painful after surgery, and because the cure is not c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9068A61K9/06A61P17/00A61P31/10A61P31/04A61K31/79A61K31/616
CPCA61K9/0014A61K9/06A61K31/616A61K31/79A61K36/15A61K36/489A61K36/9068A61K47/34A61K2300/00Y02A50/30
Inventor 施永杰张烨倩
Owner 郑州雷曼药业有限公司
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