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Antiasthmatic drug composition and double-pulse controlled-release pellet capsules thereof and preparation method

A technology of micro-pill capsule and composition is applied in the field of pharmaceutical compositions containing ephedra and bitter almond extracts to achieve the effects of reducing drug resistance, controlling asthma symptoms and improving safety

Inactive Publication Date: 2016-09-28
蚌埠丰原涂山制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After retrieval, domestic and foreign patents have not yet seen reports on double-pulse preparations of albuterol sulfate, ephedra and bitter almonds

Method used

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  • Antiasthmatic drug composition and double-pulse controlled-release pellet capsules thereof and preparation method
  • Antiasthmatic drug composition and double-pulse controlled-release pellet capsules thereof and preparation method
  • Antiasthmatic drug composition and double-pulse controlled-release pellet capsules thereof and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1 double-pulse controlled-release pellet capsule

[0043] Table 1, embodiment 1 prescription

[0044]

[0045]

[0046] Preparation

[0047] 1) Extraction of Chinese medicinal materials:

[0048] Ephedra was extracted with 5 times the amount of 0.001mol / L hydrochloric acid ethanol, refluxed 4 times, each time for 1h, the extract was concentrated, dried and pulverized. Bitter almonds are crushed into coarse powder, extracted with 8 times the amount of 90% ethanol (mass fraction, the same below) under reflux for 1.5 h, the extract is concentrated, dried and pulverized.

[0049] 2) Micropill 1 preparation: get the active ingredient (principal drug) mixture of the mixed albuterol sulfate, ephedra extract and bitter almond extract, make the ball core with 80% ethanol together with the ball core auxiliary materials, and use 4% swelling material coated with ethanol solution and dried to obtain skeleton type sustained-release pellets 1.

[0050] 3) Preparatio...

Embodiment 2

[0052] Embodiment 2: Double-pulse controlled-release pellet capsule

[0053] Table 2, embodiment 2 prescription

[0054]

[0055]

[0056] 2. Preparation method

[0057] 1) Extraction of Chinese medicinal materials:

[0058] Ephedra was extracted with 6 times the amount of 0.001mol / L hydrochloric acid ethanol, refluxed for 3 times, each time for 1.5h, the extract was concentrated, dried and pulverized. Bitter almonds are crushed into coarse powder, extracted with 7 times the amount of 95% ethanol under reflux for 1 hour, the extract is concentrated, dried and crushed.

[0059] 2) Micropill 1 preparation: take the mixed main drug mixture of salbutamol sulfate, ephedra extract and bitter almond extract, make a pellet core with 80% ethanol together with the pellet core auxiliary materials, and wrap it with 4% ethanol solution of swelling material coat and dry to obtain skeleton type sustained-release pellets 1.

[0060] 3) Preparation of micropill 2: take the mixed main...

Embodiment 3

[0063] Embodiment 3: Double-pulse controlled-release pellet capsule

[0064] Table 3: Example 3 prescription

[0065]

[0066]

[0067] 2. Preparation method

[0068] 1) Extraction of Chinese medicinal materials:

[0069] Ephedra was extracted with 4 times the amount of 0.001mol / L hydrochloric acid ethanol, refluxed 6 times, 2 hours each time, the extract was concentrated, dried and pulverized. Bitter almonds are crushed into coarse powder, extracted with 10 times the amount of 85% ethanol under reflux for 2 hours, the extract is concentrated, dried and crushed.

[0070] 2) Micropill 1 preparation: take the mixed main drug mixture of salbutamol sulfate, ephedra extract and bitter almond extract, make a pellet core with 80% ethanol together with the pellet core auxiliary materials, and wrap it with 4% ethanol solution of swelling material coat and dry to obtain skeleton type sustained-release pellets 1.

[0071] 3) Preparation of micropill 2: take the mixed main drug ...

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Abstract

The invention belongs to the field of pharmaceutical compositions, and provides an antiasthmatic drug composition. The effective ingredients of the antiasthmatic drug composition are composed of, by mass, 5 parts of salbutamol sulfate, 1-5 parts of herba ephedra extract and 1-5 parts of semen armeniacae amarae extract. The invention further provides double-pulse controlled-release pellet capsules containing the antiasthmatic drug composition. The pharmaceutical composition combines traditional Chinese medicine with western medicine, can achieve synergistic interaction, decrease the dosage and reduce the toxic and side effects of salbutamol sulfate and generation of the drug resistance and not only can control the asthma symptoms, but also can treat root causes.

Description

technical field [0001] The invention belongs to the field of pharmaceutical compositions, in particular to a pharmaceutical composition containing extracts of ephedra and bitter almonds. Background technique [0002] Bronchial asthma (abbreviated as asthma) is a common respiratory disease, caused by bronchial smooth muscle spasm, airway obstruction, more common with bronchial asthma, asthmatic bronchitis. In recent years, the prevalence of asthma has been increasing year by year worldwide. Asthma is a chronic inflammatory disease of the airway involving a variety of cells, including inflammatory cells, structural cells and cellular components of the airway. This chronic inflammation leads to airway hyperresponsiveness, often with airway obstruction, and causes recurrent episodes of wheezing, shortness of breath, chest tightness, or coughing [0003] beta 2 Receptor agonists are the first-choice drugs to control the acute attack of asthma, mainly through the β on the surfa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61K9/62A61K9/58A61P11/06A61K31/137A61K36/17
CPCA61K9/5026A61K9/5042A61K9/5084A61K31/137A61K36/17A61K36/736A61K2300/00
Inventor 马其胜李保琴孙鹏陈雪峰
Owner 蚌埠丰原涂山制药有限公司
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