A kind of preparation method of protein iron supplement iron

An iron supplement and protein iron technology, applied in the field of blood supplements, can solve the problems that users are difficult to take for a long time, not easy for consumers to accept, interfere with drug metabolism, etc., so as to reduce side effects and adverse reactions, and reduce side effects and adverse reactions. , the effect of reducing costs

Active Publication Date: 2018-12-25
HUAZHONG AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, there are dozens of types of commonly used iron supplements, but the existing iron supplements have some disadvantages: they have a heavy iron smell, which is not easily accepted by consumers; it is easy to cause gastrointestinal discomfort, and users are very It is difficult to take it consistently for a long time, and the tolerance is poor; some iron supplements will interfere with the metabolism of drugs

Method used

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  • A kind of preparation method of protein iron supplement iron
  • A kind of preparation method of protein iron supplement iron

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] (1) Disperse the commercially available magnetic iron oxide nanoparticles (average particle size less than 100nm) based on ferroferric oxide (average particle size less than 100nm) in a phosphate buffer solution with a pH of 8 at a ratio of 0.3g / mL, and then press the buffer solution Add 2.5% glutaraldehyde to the volume, and stir for 3 hours in the dark to cross-link the glutaraldehyde and magnetic iron oxide nanoparticles, wash off the uncross-linked glutaraldehyde molecules with distilled water, and disperse the nanoparticles by ultrasonic treatment for 10 s, then Ferric ions (FeCl 3 , 20mmol / L), stirred and reacted for 5h, washed away excess iron ions with distilled water, and prepared as a magnetic nanoparticle carrier;

[0022] (2) Dilute the egg white 8 times, adjust the pH to 8.5, then add the magnetic nanoparticle carrier by 0.5% of the solution weight, stir for 10 minutes, and make the ovotransferrin in the solution and the ferric iron on the magnetic nanopart...

Embodiment 2

[0026] (1) is identical with the step (1) of embodiment 1;

[0027] (2) Milk is diluted 5 times, and the pH of the solution is adjusted to 6.8, then the magnetic nanoparticle carrier is added by 0.02% of the solution weight, and stirred for 5 minutes, so that the transferrin in the solution and the ferric ion on the magnetic nanoparticle carrier combined;

[0028] (3) Adsorb the magnetic nanoparticle carrier that has absorbed transferrin to the bottom of the solution with a magnet, discard the upper layer solution, wash the lower floor solid with a buffer solution with a pH of 6.8, then transfer to a buffer solution with a pH of 3.2, and stir for 60 Minutes, the combined transferrin is released from the magnetic nanoparticle carrier; the magnetic nanoparticle carrier is separated from the solution with a magnet again, and FeCl is added to the solution 3 (20mmol / L) reaction, obtain iron binding transferrin after drying;

[0029] (4) Take 100g of iron-bound transferrin, 0.1g o...

Embodiment 3

[0031] (1) is identical with the step (1) of embodiment 1;

[0032] (2) Dilute the egg white 10 times, adjust the pH of the solution to 9.5, then add the magnetic nanoparticle carrier by 1% of the solution weight, stir for 60 minutes, and make the transferrin in the solution and the ferric iron on the magnetic nanoparticle carrier ion binding;

[0033] (3) Adsorb the magnetic nanoparticle carrier that has absorbed transferrin to the bottom of the solution with a magnet, discard the upper layer solution, wash the lower floor solid with a buffer solution with a pH of 9.5, then transfer to a buffer solution with a pH of 4.8, and stir for 5 Minutes, the combined transferrin is released from the magnetic nanoparticle carrier; the magnetic nanoparticle carrier is separated from the solution with a magnet again, and FeCl is added to the solution 3 (5mmol / L) reaction, obtain iron binding transferrin after drying;

[0034] (4) Take 100g of iron-binding transferrin, 0.5g of ferrous fu...

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Abstract

The invention discloses a preparation method of a transferrin and Fe combined Fe supplementing agent. According to the preparation method, a magnetic nanoparticle carrier is subjected to a reaction with a sample solution, transferrin in the sample solution is enabled to be bound with Fe<3+> on the magnetic nanoparticle carrier; then the magnetic nanoparticle carrier with the transferrin adsorbed is separated from the solution by a magnet, through regulation of the pH value, the bound transferrin is released again from the magnetic nanoparticle carrier to be reacted with FeCl3, and Fe-binding transferrin is obtained after drying; the Fe-binding transferrin is mixed with ferrous fumarate, L-ascorbic acid, a blood supplementing traditional Chinese medicine extract and a pharmaceutically acceptable carrier, and the transferrin and Fe combined Fe supplementing agent is prepared. The preparation method has the advantages that the Fe supplementing effect is good, few side effects and adverse reactions are produced and the like.

Description

technical field [0001] The invention belongs to the field of blood supplements, and in particular relates to a preparation method of protein iron supplements. Background technique [0002] Iron ion is an essential trace element for the human body. It participates in the synthesis of hemoglobin and is the guarantee for the body to transport and supply oxygen. Iron deficiency is an important factor that causes anemia. More than 50% of anemia (i.e. iron deficiency anemia, IDA) is caused by iron deficiency, and nutritional fortification of iron deficiency groups through iron supplements is an important method for prevention and treatment. Effective measures for iron deficiency and iron deficiency anemia. [0003] At present, there are dozens of types of commonly used iron supplements, but the existing iron supplements have some disadvantages: they have a heavy iron smell, which is not easily accepted by consumers; it is easy to cause gastrointestinal discomfort, and users are v...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/26A61K47/64A61P7/06A61K35/36A61K36/725A61K36/815
CPCA61K33/26A61K35/36A61K36/725A61K36/815A61K2300/00
Inventor 马美湖耿放袁小军任国栋何恩祺付星王一博
Owner HUAZHONG AGRI UNIV
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