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Mixed preparation of iron and vitamins and its preparation method

A vitamin and preparation technology, applied in the field of pharmacy, can solve the problems such as unsatisfactory effect of ferrous sulfate sustained-release control agent, affecting the absorption of ferrous sulfate, etc., and achieve the effects of being beneficial to absorption and increasing solubility

Active Publication Date: 2017-09-19
SHANGHAI YANAN PHARM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the slow release of slow controlled release, the drug can only be partially released in the stomach. With the transfer of ferrous sulfate in the digestive system, the pH value gradually increases and oxidizes and precipitates, which affects the absorption of ferrous sulfate.
Therefore, the effect of the unilateral ferrous sulfate sustained-release control agent is not ideal

Method used

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  • Mixed preparation of iron and vitamins and its preparation method
  • Mixed preparation of iron and vitamins and its preparation method
  • Mixed preparation of iron and vitamins and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] This example relates to a mixed preparation of iron and vitamins, whose components and proportions are shown in Table 1.

[0035] The preparation method of the mixed preparation of the iron and vitamins is as follows:

[0036] A. Put the liquid sugar into the ingredients pot.

[0037] B. After diluting part of the glycerin with boiling purified water, put it into the batching pot.

[0038] C. Sodium benzoate is dissolved in a small amount of boiling purified water and added to the batching pot.

[0039] D, boil solid sugar into 50% syrup, stir and reflux for 20min.

[0040] E. Dilute the syrup with boiling purified water, cool it, and throw water-soluble vitamins (vitamin B 6 , vitamin C), cysteine ​​hydrochloride, ferrous sulfate, sodium metabisulfite, stir evenly and reflux for 20 minutes, filter to obtain ferrous sulfate compound agent; add to the batching pot.

[0041] F. Sodium glutamate is dissolved in a small amount of boiling purified water and added to the ...

Embodiment 2

[0049] This example relates to a mixed preparation of iron and vitamins, whose components and proportions are shown in Table 1.

[0050] The preparation method of the mixed preparation of the iron and vitamins is as follows:

[0051] A. Put the liquid sugar into the ingredients pot.

[0052] B. After diluting part of the glycerin with boiling purified water, put it into the batching pot.

[0053] C. Sodium benzoate is dissolved in a small amount of boiling purified water and added to the batching pot.

[0054] D. Boil the solid sugar into 50% syrup, stir and reflux for 10min.

[0055] E. Dilute the syrup with boiling purified water, cool it, and throw water-soluble vitamins (vitamin B 6 , vitamin C), cysteine ​​hydrochloride, ferrous sulfate, sodium metabisulfite, stir and reflux for 30 minutes, filter to obtain ferrous sulfate compound; add to the batching pot.

[0056] F. Sodium glutamate is dissolved in a small amount of boiling purified water and added to the ingredien...

Embodiment 3

[0064] This example relates to a mixed preparation of iron and vitamins, whose components and proportions are shown in Table 1.

[0065] The preparation method of the mixed preparation of the iron and vitamins is as follows:

[0066] A. Put the liquid sugar into the ingredients pot.

[0067] B. After diluting part of the glycerin with boiling purified water, put it into the batching pot.

[0068] C. Sodium benzoate is dissolved in a small amount of boiling purified water and added to the batching pot.

[0069] D. Boil the solid sugar into 50% syrup, stir and reflux for 20min.

[0070] E. Dilute the syrup with boiling purified water, cool it, and throw water-soluble vitamins (vitamin B 6 , vitamin C), cysteine ​​hydrochloride, ferrous sulfate, sodium metabisulfite, stir evenly and reflux for 10 minutes, filter to obtain the ferrous sulfate compound; add to the batching pot.

[0071] F. Sodium glutamate is dissolved in a small amount of boiling purified water and added to th...

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Abstract

The invention discloses a mixed preparation of iron and vitamins and a preparation method thereof; the mixed preparation includes the following components in weight percent: ferrous sulfate compound 10-20%, vitamin B120.000125-1.5%, Glycerin 4-8%, liquid sugar 65-75%, sodium glutamate 0-1%, sodium benzoate 0-1%, ethanol 0.25-1%, single caramel color 0-1%, pigment 0-1%, Vanilla essence 0-1%, lemon essence 0-1%, water 5-10%. The ferrous sulfate compound agent is compounded by ferrous sulfate, vitamin B6, vitamin C, cysteine ​​hydrochloride, sodium metabisulfite and solid sugar. The mixed preparation of the present invention is a novel ferrous sulfate compound preparation based on ferrous sulfate with good absorption effect, no damage to gastrointestinal mucosa, stable absorption, and no side effects. While effectively improving iron deficiency anemia, it can also To achieve the purpose of supplementing multiple nutrients at the same time and effectively improving malnutrition.

Description

technical field [0001] The invention belongs to the field of pharmacy, and in particular relates to a mixed preparation of iron and vitamins and a preparation method thereof. Background technique [0002] Iron is one of the essential elements that make up the human body. Iron deficiency will affect the health and development of the human body. The biggest impact is iron deficiency anemia. The survey by the World Health Organization shows that about 50% of girls, 20 Iron deficiency anemia occurs in 40% of adult women and 40% of pregnant women. Iron supplementation is the process of supplementing the human body with necessary and appropriate amounts of inorganic iron or organic iron compounds through food or special nutrients, so as to supplement iron elements to achieve the purpose of strengthening the body, preventing or assisting the treatment of diseases. [0003] Clinically, ferrous sulfate is the drug of choice for the treatment of iron deficiency anemia, but the ordina...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K33/26A61P7/06A61P3/02A61K31/375A61K31/4415
Inventor 王学亮
Owner SHANGHAI YANAN PHARM
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