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A Novel Copper Ion Fluorescent Molecular Probe and Its Application

A technology of fluorescent probes and ions, which is applied in the direction of fluorescence/phosphorescence, material analysis and material analysis through optical means, and can solve the problems of interfering ions, inability to detect on-site in real time, expensive instruments, etc.

Active Publication Date: 2017-11-28
WENZHOU MEDICAL UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, there are more or less defects in these methods, such as complicated sample preparation steps, serious influence of interfering ions, expensive instruments, long detection time, and inability to perform real-time on-site detection.

Method used

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  • A Novel Copper Ion Fluorescent Molecular Probe and Its Application
  • A Novel Copper Ion Fluorescent Molecular Probe and Its Application
  • A Novel Copper Ion Fluorescent Molecular Probe and Its Application

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Embodiment Construction

[0021] figure 1 It is the fluorescence spectrum diagram of the interaction between the fluorescent probe and different metal ions. As can be seen from the fluorescence curve in the figure, the fluorescent probe itself has almost no fluorescence. When 4 times the equivalent of copper ions are added, the fluorescence intensity is significantly enhanced, and 10 times the equivalent of alkali metal (K + , Na + , Li + ), alkaline earth metals (Ca 2+ ) and transition metals (Mn 2+ , Al 3+ ,Co 2+ , Pb 2+ ) did not cause significant changes in the spectrum, so the Cu 2+ Ions show a specific recognition effect.

[0022] figure 2 It is a histogram of the change in fluorescence intensity of fluorescent probes interacting with different metal ions at 455nm. It can be seen from the figure that the fluorescence intensity of fluorescent probes at 455nm is enhanced by 35 times with the addition of only 4 times the amount of copper ions. This is because the N atom on the C=N double ...

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Abstract

The invention provides a fluorescent probe for bivalent copper ions and a preparation method of the fluorescent probe. The method comprises the steps of dissolving 6-methoxyl-2-naphthaldehyde in a reaction flask by taking methanol as a solvent, and heating up to 40-50 DEG C; dissolving carbohydrazide by taking water as a solvent, then dropwise adding the dissolved carbohydrazide into the reaction flask, and carrying out reflux reaction for 3h; after the reaction, filtering and drying a mixed solution for removing the solvents to obtain the Schiff base fluorescent probe for the copper ions. The method is simple in operation, convenient and fast, low in cost of a needed intermediate and easy in control of reaction process; the product is easy to separate, high in yield and high in purity. The fluorescent probe has special recognition performance for the copper ions, thus having wide application prospect in the aspects of sensor technologies, photochemistry, electroluminescent devices, and the like.

Description

technical field [0001] The invention relates to the technical field of fluorescent sensor preparation, and in particular provides a method for quickly, sensitively and conveniently detecting low-concentration copper ions in aqueous solution and biological applications. Background technique [0002] Life activities are the result of various chemical reactions in which many biologically active substances participate, and metal ions are one of the important ones. The essential trace metal elements in organisms directly participate in almost all physiological processes in the organism, and they play an important role in maintaining the basic structure of biological macromolecules such as proteins, nucleic acids, peptides and hormones and realizing their normal functions. And some other metal elements, especially heavy metal elements, will produce greater toxicity and damage to organisms when the concentration is low. In recent years, with the rapid development of science and te...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C281/14C09K11/06G01N21/64
CPCC07C281/14C09K11/06C09K2211/1011G01N21/6428G01N21/643
Inventor 王旸孙聪聪黄烨炜王涛丛维涛金利泰
Owner WENZHOU MEDICAL UNIV
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