32 results about "2-naphthaldehyde" patented technology

The present invention relates to a new synthetic method of nafamostat mesylate intermediate - 6-amidino-2-naphthol mesylate. The new method uses 6-hydroxyl-2-naphthaldehyde as a raw material, and uses dimethyl sulfoxide as a reaction solvent to react with hydroxylamine hydrochloride for addition and elimination to obtain 6-cyano-2-naphthol, 6-cyano-2-naphthol A pinner reaction occurs in HCl / methanol solution to obtain 6-hydroxyl-2-naphthiminomethyl ester hydrochloride, and then feed ammonia to carry out ammonolysis reaction to obtain 6-amidino-2-naphthol, 6-amidino ‑2‑naphthol is successively reacted with sodium bicarbonate and methanesulfonic acid to be converted into 6‑amidino‑2‑naphthol mesylate. In the new synthetic method, the preparation of the first step 6-cyano-2-naphthol adopts a brand-new method, which avoids the use of highly toxic copper cyanide in the traditional method, and is simple to operate and mild in condition; the second step adopts an improved The pinner method uses the reaction of acetyl chloride and methanol to generate HCl instead of directly passing HCl gas into the reaction system. The improved method is more operable and easier to realize industrialization.

The invention belongs to the field of organic chemistry, and in particular relates to 6'-hydroxyl naphthyl-2-cyanoacrylate. The chemical structure of the 6'-hydroxyl naphthyl-2-cyanoacrylate is shown in formula (I) which is as shown in the description, wherein R is methyl, ethyl, propyl and butyl, 2-(2-methoxy ethyoxyl) ethyoxyl or 2-(N,N-dimethyl) aminoethyl. The 6'-hydroxyl naphthyl-2-cyanoacrylate is obtained by performing reaction on 6'-hydroxyl-2-naphthaldehyde and 2-cyan-acetic ester. The 6'-hydroxyl naphthyl-2-cyanoacrylate has fluorine ion fluorescence recognition performance and can be used for detecting fluorine ions in cells.

The invention discloses a synthesis method of high-temperature-resistant polyarylene ether nitrile resin. The synthesis method is characterized by comprising the following steps: placing 2-naphthaldehyde, 2,6-xylenol and toluene in a reaction kettle, dropwise adding a sulfuric acid aqueous solution and 3-thiohydracrylic acid under nitrogen atmosphere, heating and concentrating after washing by deionized water and toluene, separating out a crystal and drying to obtain a bisphenol functional monomer; adding 2,6-dichlorobenzonitrile, a diphenol monomer, the bisphenol functional monomer, anhydrous potassium carbonate, N, N-dimethylpyrrolidine and toluene to the reaction kettle, carrying out heat preservation to obtain a polycondensation product; adding the polycondensation product to deionized water or the sulfuric acid aqueous solution to be boiled, performing suction filtration, washing a solid by deionized water and then drying the solid to prepare the high temperature resistant polyarylene ether nitrile resin. According to the invention, the bisphenol monomer of which the side group contains a naphthalene ring structure is introduced into molecules of the traditional polyarylene ether nitrile, so that the prepared polyarylene ether nitrile resin has good heat resistance and processing properties.