44 results about "Addition elimination" patented technology

The invention relates to a quinoline nitrile derivative. A method comprises the following steps of: reacting 2-methylquinoline serving as an initial raw material with the corresponding alkyl halide to obtain quaternary ammonium salt, performing Michael addition-elimination reaction on the quaternary ammonium salt and malononitrile, and performing Knoevenagel condensation reaction on the obtained compound and the corresponding aromatic aldehyde to obtain a target product. The aggregate or solid substance of the derivative has strong fluorescence and large wavelength, is a good aggregation-induced emission material, and has considerable application prospects in the fields of electroluminescent devices, fluorescent probes, intelligent materials, organism imaging and the like.

The invention discloses preparation of near-infrared dye based on aza-fluoroborane and application. The near-infrared dye is prepared from thiophene-containing groups and a basic aza-fluoroborane framework. The aza-fluoroborane dye is prepared by the following steps: (1) synthesis of ketene: the ketene is obtained by addition-elimination reaction of aldehyde and ketone under an alkali condition; (2) ketene and nitromethane conduct addition reaction under the alkali condition; (3) ring-forming reaction: under the condition with existence of an ammonia source, two times of equivalent ketene andnitromethane conduct ring-forming reaction; (4) coordination reaction: products obtained in the step (3) and metal or boron difluoride are coordinated to obtain a target product. The preparation and the application disclosed by the invention have the advantages that the target dye has strong near-infrared absorption (the molar light absorption coefficient is more than 100000M<-1>cm<-1>), high singlet oxygen yield and good photothermal effect, and can be used for photodynamic and photothermal synergy with single-wavelength excitation for tumor treatment under the guidance of photothermal imaging, photoacoustic imaging and fluorescence imaging.

The invention relates to a method for synthesizing 2, 3, 5 (Z)-trienol containing fluorine in a high-zone and stereoselectivity way, i.e. 2, 3, 5 (Z)-trienol compound containing fluorine is synthesized through the addition-elimination reaction of Grignard reagent and 5-perfluoroalkyl-4(E)-olefin-2-alkyne-1-alcohol. The method is simple to operate and easy to obtain raw materials and reagent; the reaction has high-zone and stereoselectivity without participation of noble metal, can simultaneously introduce a plurality of substitutional groups, has high yield and easy separation and purification of the product, and is suitable for synthesizing various 2, 3, 5 (Z)-trienols containing fluorine.

The present invention relates to a new synthetic method of nafamostat mesylate intermediate - 6-amidino-2-naphthol mesylate. The new method uses 6-hydroxyl-2-naphthaldehyde as a raw material, and uses dimethyl sulfoxide as a reaction solvent to react with hydroxylamine hydrochloride for addition and elimination to obtain 6-cyano-2-naphthol, 6-cyano-2-naphthol A pinner reaction occurs in HCl / methanol solution to obtain 6-hydroxyl-2-naphthiminomethyl ester hydrochloride, and then feed ammonia to carry out ammonolysis reaction to obtain 6-amidino-2-naphthol, 6-amidino ‑2‑naphthol is successively reacted with sodium bicarbonate and methanesulfonic acid to be converted into 6‑amidino‑2‑naphthol mesylate. In the new synthetic method, the preparation of the first step 6-cyano-2-naphthol adopts a brand-new method, which avoids the use of highly toxic copper cyanide in the traditional method, and is simple to operate and mild in condition; the second step adopts an improved The pinner method uses the reaction of acetyl chloride and methanol to generate HCl instead of directly passing HCl gas into the reaction system. The improved method is more operable and easier to realize industrialization.

An isolongifolenone oxime ether derivative is prepared by the following steps of: taking isolongifolenone as the raw material, synthesizing isolongifolenone oxime through addition-elimination reaction, and performing alkylation reaction of the isolongifolenone oxime. Simultaneously, the isolongifolenone oxime ether derivative disclosed by the invention can inhibit bacteria, such as staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, bacillus proteus vulgaris and pseudomonas aeruginosa, and fungus, such as Aspergillus niger, exserohilum turcicum, corn sheath blight, alternaria musae Bovr.et Bat. and colletotrichum musae; and the isolongifolenone oxime ether derivative has the excellent insecticidal action for insect pests, such as aphid and rice planthopper.

A method of preparing (S)-2-amino-5-methoxytetralin hydrochloride[(S)-2-amino-5-methoxyl-1,2,3,4-tetrahydronaphthalene hydrochloride], comprising the steps of: (1) producing a compound (I) by addition-elimination reaction of 5-methoxy-2-tetralone and R-(+)-a-phenylethylamine; (2) producing a compound (II) by reduction reaction of the compound (I) with a reducing agent; and (3) producing a compound (II) hydrochloride by reacting the compound (II) with a salt-forming agent, then carrying out reduction reaction with a palladium-carbon catalyst to produce (S)-2-amino-5-methoxytetralin hydrochloride. The method can significantly increase the yield of (S)-2-amino-5-methoxytetralin hydrochloride with short synthetic path, low preparation cost and less pollution, which is environmentally friendly and is suitable for medical industrialized production. The structural formulae of the compound (I) and the compound (II) are:respectively.