61 results about "Dihydropyridine derivatives" patented technology

A photosensitive resin composition contains a component (A) and at least one of a component (B) and a component (C). In addition, in the circuit board with metal support including: a metal support; a base insulating layer; a conductive layer formed of a wiring circuit pattern; and a cover insulating layer, at least one of the above-mentioned base insulating layer and cover insulating layer is made of the above-mentioned photosensitive resin composition.

• (A) a 1,4-dihydropyridine derivative represented by the following general formula (1)

where R₁ represents an alkyl group having 1 to 3 carbon atoms; and R₂ and R₃ each represent a hydrogen atom or an alkyl group having 1 or 2 carbon atoms and may be identical to or different from each other;

• (B) the following (x) and (y):
  • (x) a carboxyl group-containing linear polymer; and
  • (y) an epoxy resin
• (c) a linear polymer having a carboxyl group and an epoxy group

A photosensitive polyimide resin precursor composition capable of providing a polyimide resin that is not substantially colored, is transparent and has heat resistance, an optical polyimide resin obtained from the composition, and an optical waveguide using the polyimide resin. The photosensitive polyimide resin precursor composition contains (a) 100 parts by weight of a polyamic acid obtained from a tetracarboxylic acid dianhydride and a diamine, (b) 0.01 parts by weight or more and less than 5 parts by weight of a 1,4-dihydropyridine derivative, (c) 5-50 parts by weight of a glycol (ether). The optical polyimide resin is obtained by irradiating the photosensitive resin precursor composition with UV light, followed by exposure, heating, development, and then heating. The optical waveguide comprises a core layer comprising the optical polyimide resin, and a cladding layer thereof.

The invention discloses a method for asymmetric synthesis of levorotation menthol. The method comprises the following steps: citral is taken as an initial raw material, a dihydropyridine derivant is taken as a negative hydrogen source, chiral amine serves as a chiral auxiliary agent for catalytic and asymmetric hydrogenization synthesis of dextrorotation citronellal, the dextrorotation citronellal is catalyzed by Lewis acid for ring-closing synthesis of levorotation isopulegol, and the levorotation isopulegol is subject to catalytic hydrogenation to finally produce the levorotation menthol. The total yield of the levorotation menthol produced by adopting the method is larger than 60 percent, and the ee (enantiomeric excess) value is larger than 90 percent. The method has the characteristics of mild reaction conditions, simple synthetic process, simplicity in catalyst preparation, convenience in catalyst recovery and the like and is suitable for large-scale industrial production of levorotation menthol.

The invention relates to the field of probes, in particular to an application of a 1,4-dihydropyridine derivative as a NO fluorescent probe. According to the invention, based on the specific effect of the 1,4-dihydropyridine derivative and nitric oxide, (aromatization, resulting in the changes of electronic structure distribution and molecular conformation in the probes) features of corresponding pyridine derivatives are produced, to realize the response of the fluorescent probe to nitric oxide. Based on the changes of the fluorescence in nature before and after the detection (changes in fluorescence emission intensity, fluorescence emission wavelength, fluorescence emission service life and the like), the detection for the nitric oxide is realized.

The invention discloses an asymmetric synthesis method of dextral citronellal. The method takes citral as a starting material, dihydropyridine derivative as a negative hydrogen source, and chiral amine salt as a chiral auxiliary agent, and asymmetric hydrogenation reaction is generated in a bi-catalytic system to synthesize dextral citronellal. By adopting the synthesis method disclosed by the invention for the synthesis of dextral citronellal, the total yield is more than 85%, and the ee (enantiomeric excess) value is greater than 80%; the synthesis method has the characteristics of mild reaction conditions, simple synthesis process, simple catalyst preparation, convenience in recycling and the like, and is suitable for industrial production of dextral citronellal.

The invention belongs to the field of organic catalysis, and discloses a novel 1, 4-dihydropyridine bifunctional chiral catalyst and a preparation method and application thereof. The general chemicalstructure formula of the chiral catalyst is shown in formula (I) as shown in specification. According to the invention, a 1, 4-dihydropyridine derivative and a chiral tetrahydropyrrole derivative areused as raw materials, and finally, the novel 1, 4-dihydropyridine bifunctional chiral catalyst is synthesized. The method has mild synthesis reaction conditions and high yield. The operation steps are simple, safe and reliable; the catalyst is environment-friendly, and can be applied to the fields of asymmetric catalytic transfer hydrogenation, chiral fine chemical synthesis, chiral drug or drugintermediate synthesis, chiral new materials, chiral functional molecule synthesis and the like; and the application prospect is wide.

A process of producing a polymer optical waveguide, including (a) a step of forming an undercladding layer on a substrate; (b) a step of forming a photosensitive resin composition layer containing a 1,4-dihydropyridine derivative and a resin on the undercladding layer; (c) a step of irradiating a region of the photosensitive resin composition layer corresponding to a core pattern with UV light through a mask to form UV light-exposed areas and UV light-unexposed areas on the photosensitive resin composition layer; (d) a step of heating the UV light-exposed areas and UV light-unexposed areas of the photosensitive resin composition layer; and (e) a step of forming an overcladding layer on the photosensitive resin composition layer after heating.

An excellent medicine for the treatment or prevention of hypertension or the like is provided. A specific acid addition salt of (R)-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3- yl)ester 5-isopropyl ester is useful as a medicine for the treatment or prevention of hypertension or the like.

The invention discloses a method for catalytically synthesizing a 1,4-dihydropyridine derivative through cooperation of zirconocene dichloride and benzoic acid ligands. According to the method, with the zirconocene dichloride as a catalyst and 3-nitrophthalic acid, 4-nitrophthalic acid, 5-methoxysalicylic acid, 5-nitrosalicylic acid, 3,5-dinitrosalicylic acid and the like as the ligands, intermolecular ring closure is performed between enamine ester and cinnamaldehyde to produce the 1,4-dihydropyridine derivative. By the method, a reaction condition is mild, the operation is simple, the reaction time is short, a reaction product is single, the atomic economy is high, and after the reaction, the 1,4-dihydropyridine derivative with wide biological activity and a high medicinal value can be obtained at a relatively high yield only through simple column chromatographic separation of the product.

The invention relates to a preparation method for a 1, 2-dihydropyridine derivative, particularly a new method for preparation of the 1, 2-dihydropyridine derivative from a 3-aza-1, 5-eneyne derivative under the promotion (catalysis) of protonic acid through cyclization reaction. The method takes the 3-aza-1, 5-eneyne derivative as the raw material to generate the 1, 2-dihydropyridine derivative under two conditions. According to the condition A, alcohol is adopted as a solvent (also serving as a catalyst), other catalysts or additives are unnecessary, and reaction is carried out at a temperature ranging from room temperature to 140DEG C; or according to the condition B, alcohol, phenol or protonic acid is added into another organic solvent to serve as a catalyst. The yield of 1, 2-dihydropyridine derivative can reach up to 97%.

The invention relates to a method for preparing 1, 4-dihydropyridine derivatives. In the presence of a resin catalyst, a compound of formula II and a compound of formula III are reacted for 1 to 36 hours at a temperature between 0 and 150 DEG C to obtain the 1, 4-dihydropyridine derivatives represented by formula I, wherein R1 is hydrogen; C1-5 is alkyl and the like; R2 is phenyl or substituted phenyl; R3 is C1-5 alkyl or C1-5 alkanoyl and the like; and X is halogen, nitryl, cyano, sulfonic alkyl or hydroxyl. The catalyst used by the method has high catalytic activity, reaction conditions are mild and separation of product is easy; the method has no environment pollution, no erosion to equipment, and simple post treatment; the catalyst can be repeatedly used and regenerated, the reaction is easy to control, and good yield can be maintained; and the prepared product has good quality, and the method is suitable for mass production, in particular for large-scale production and preparation of raw material drugs or medicine.

The present invention pertains to the field of oral pharmaceutical composition of dihydropyridine derivatives. In particular, present invention relates to oral solution formulations of dihydropyridines with non-aqueous solvent and antioxidant having improved stability.

The invention disclosed some 1,4-dihydropiridine derivative chemically with guaiacoxypropanolamine based phenoxypropanolamine moiety and pharmacologically with beta-adrenoceptor blocking and partial beta2-agonist activities, is now emerging. The compound of 1,4-dihydropiridine derivative wherein has the formula I, wherein R selected from four group as follow R1 selected from X, H, NO2 saturated C1-C6 alkyl chain, unsaturated C6-C6 alkyl chain, R2 selected from H, CH3 R3 and R4 are individually selected from saturated C1-C6 alkyl chain, unsaturated C1-C6 alkyl chain; R5 selected from OH, saturated C1-C6 alkyl chain, unsaturated C1-C6 alkyl chain.

The invention provides 1,4-dihydropyridine derivatives of formula (I) wherein R¹ is optionally substituted C_6-24aryl group or 5 to 6 membered heteroaryl group comprising 1 to 3 nitrogen atoms or other heteroatoms like oxygen and sulphur, and combinations thereof; R² and R³ are independently hydrogen or C_1-6alkyl group; R⁴ and R⁵ are independently hydrogen, C_1-6alkyl group optionally substituted with amino, mono- or di(C_1-6alkyl)amino, or with 5 to 24 membered optionally fused heterocyclic ring attached by nitrogen and optionally comprising additional 1 to 3 N, O, S heteroatoms and optionally substituted with C_1-6alkyl group or C_1-6 alkoxy group; R⁶ is C_1-6alkyl, C_3-7cycloalkyl, C_3-7cycloalkylC_1-6alkyl or arylC_1-6alkyl group; and stereoisomers including enantiomers, diastereomers, racemic mixtures, mixture of enantiomers and combination thereof, as well as polymorphs, pharmaceutically acceptable salts, solvates, esters and prodrugs thereof for use in the therapeutic or prophylactic treatment of a disorder mediated by heat shock proteins.

The invention belongs to the technical field of medicine, particularly relates to a dihydropyridine derivative disclosed in a general formula (I) and clinically-acceptable salt thereof, wherein R1, R2, R3, R4, R5, X or n is defined as in a specification. The invention also relates to a preparation method of the compounds and the application of the compounds in preparing medicines capable of treating hypertension.

The use of dihydropyridine-5-phosphonic acid cyclic propylene ester derivatives of formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of said compound or prodrug in the treatment of cancers, pre-cancerous conditions and other conditions is disclosed, wherein each of R₁-R₈ are the same or different, are hydrogen or C₁-C₆ alkyl; one of X₁ and X₂ is nitro while the other is hydrogen; each of Y₁ and Y₂ may be the same or different, is phenyl which may be substituted by chlorine, fluorine or alkoxy; and m and n are integers from 0-4, a prodrug thereof, or a pharmaceutically acceptable salt thereof.

A positive photosensitive resin composition comprising (A) a polyamic acid, (B) a 1,4-dihydropyridine derivative represented by the general formula (II):

wherein R² is a monovalent organic group; each of R³, R⁴, R⁵, and R⁶ is independently hydrogen or a monovalent organic group; and Ar—NO₂ is an aromatic hydrocarbon group having a nitro group at ortho-position, and (C) an amine compound.

Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel such as encephalopathies caused by the ischemia in the acute phase after the onset of cerebral infarction, cerebral hemorrhage or the like, Alzheimer's disease, etc.

The invention provides a preparation method of 2,6-pyridinedicarboxylic acid. The preparation method comprises the following steps: taking 1,7-pimelic acid or 1,7-pimelic acid diester (I) as a raw material to carry out a halogenation reaction to obtain 2,2,6,6-tetrahalide (II), then carrying out a cyclization reaction with ammonia to prepare a dihydropyridine derivative (III), and carrying out oxidation by an oxidizing agent or carrying out oxidation-hydrolysis to obtain the 2,6-pyridinedicarboxylic acid. According to the method disclosed by the invention, raw materials are cheap and easily available, and the preparation method is simple, is easy to implement, and is safe and environmentally friendly. The amount of wastewater is small, cost is low, the yield and selectivity are high, byproducts are fewer, and the preparation method is suitable for industrial production.

Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula:

analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.

The present invention discloses amphiphilic 1,4-dihydropyridine derivatives useful for the preparation of a composition for delivering nucleotide containing compounds into a target cell and/or its nucleus. Said composition comprises 1,4-dihydropyridine derivatives having a good DNA condensing capacity and capability of self-association. Also disclosed are composition comprising said derivatives complexed with nucleotide containing compounds as well methods for the producing of said complexes. The invention is also related to the use of said 1,4-dihydropyridine derivatives for manufacturing systems for delivering nucleotide containing compounds useful in gene therapy and DNA vaccination.

The invention discloses a heat stabilizer composition for transparent PVC (polyvinyl chloride) and application thereof. The heat stabilizer composition at least contains a dihydropyridine derivative as a main heat stabilizer; and the heat stabilizer composition further comprises an amine anti-aging agent serving as an auxiliary heat stabilizer A, a phenolic antioxidant serving as an auxiliary heat stabilizer B and a phosphite antioxidant serving as an auxiliary heat stabilizer C. The prepared PVC has excellent static thermal stability and dynamic thermal stability, and the used materials meet the environmental protection requirement and have no peculiar smell.

The invention belongs to the technical field of catalytic organic synthesis, and particularly relates to a preparation method and application of a novel ionic beta-naphthol aldehyde Schiff base zirconium complex. Zirconium atoms are coordinated with a beta-naphthol aldehyde Schiff base ligand and water molecules, and two perfluoroalkyl (aryl) sulfonic acid groups are combined with central atom zirconium through covalent bonds and ionic bonds respectively. The preparation method comprises the following steps: dissolving beta-naphthol aldehyde Schiff base zirconium dichloride in a solvent, adding a silver salt under the protection of N2, reacting the mixture for 1-4 hours in a dark place at room temperature, performing filtration, adding n-hexane into filtrate until layering, putting the solution into a refrigerator, and freezing the solution for 24 hours to separate out the beta-naphthol aldehyde Schiff base zirconium complex. The beta-naphthol aldehyde Schiff base zirconium complex hashigh air stability and strong Lewis acidity, and can efficiently catalyze the Hantzsch reaction of aldehyde, beta-ketoester and ammonium acetate to synthesize 1,4-dihydropyridine derivatives.

The present invention relates to Chemistry, Pharmaceutical and in particular to the preparation of formulations from derivatives of phenolic or polyphenolic compounds and from derivatives of phenolic or polyphenolic compounds combined with tricyclic systems of the benzodiazepine type fused to derivatives of 1,4-dihydropyridines with action on the Central Nervous and Vascular Systems.

These pharmaceutical compositions exhibit GABAergic, antiglutamatergic, calcium channel modulating, mitoprotective, anti-oxidant, anti-inflammatory, and antiapoptotic action, usable in the treatment of cardiovascular, cerebrovascular, neurodegenerative, neuropsychiatric and neurological diseases.