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62 results about "Dihydropyridine derivatives" patented technology
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Photosensitive resin composition and circuit board with metal support using the same
InactiveUS20120067626A1Curing shrinkage is smallSatisfactory photosensitivityPhotosensitive materialsPhotomechanical apparatusEpoxyDihydropyridine
A photosensitive resin composition contains a component (A) and at least one of a component (B) and a component (C). In addition, in the circuit board with metal support including: a metal support; a base insulating layer; a conductive layer formed of a wiring circuit pattern; and a cover insulating layer, at least one of the above-mentioned base insulating layer and cover insulating layer is made of the above-mentioned photosensitive resin composition.(A) a 1,4-dihydropyridine derivative represented by the following general formula (1)where R1 represents an alkyl group having 1 to 3 carbon atoms; and R2 and R3 each represent a hydrogen atom or an alkyl group having 1 or 2 carbon atoms and may be identical to or different from each other;(B) the following (x) and (y):(x) a carboxyl group-containing linear polymer; and(y) an epoxy resin(c) a linear polymer having a carboxyl group and an epoxy group
Owner:NITTO DENKO CORP
Photosensitive polyimide resin precursor composition, optical polyimide obtained from the composition, optical waveguide using the polyimide, and process for producing the optical waveguide
A photosensitive polyimide resin precursor composition capable of providing a polyimide resin that is not substantially colored, is transparent and has heat resistance, an optical polyimide resin obtained from the composition, and an optical waveguide using the polyimide resin. The photosensitive polyimide resin precursor composition contains (a) 100 parts by weight of a polyamic acid obtained from a tetracarboxylic acid dianhydride and a diamine, (b) 0.01 parts by weight or more and less than 5 parts by weight of a 1,4-dihydropyridine derivative, (c) 5-50 parts by weight of a glycol (ether). The optical polyimide resin is obtained by irradiating the photosensitive resin precursor composition with UV light, followed by exposure, heating, development, and then heating. The optical waveguide comprises a core layer comprising the optical polyimide resin, and a cladding layer thereof.
Owner:NITTO DENKO CORP
Method for asymmetric synthesis of levorotation menthol
InactiveCN103044204AEasy to makeMild reaction conditionsPreparation by hydrogenationLewis acid catalysisDihydropyridine derivatives
The invention discloses a method for asymmetric synthesis of levorotation menthol. The method comprises the following steps: citral is taken as an initial raw material, a dihydropyridine derivant is taken as a negative hydrogen source, chiral amine serves as a chiral auxiliary agent for catalytic and asymmetric hydrogenization synthesis of dextrorotation citronellal, the dextrorotation citronellal is catalyzed by Lewis acid for ring-closing synthesis of levorotation isopulegol, and the levorotation isopulegol is subject to catalytic hydrogenation to finally produce the levorotation menthol. The total yield of the levorotation menthol produced by adopting the method is larger than 60 percent, and the ee (enantiomeric excess) value is larger than 90 percent. The method has the characteristics of mild reaction conditions, simple synthetic process, simplicity in catalyst preparation, convenience in catalyst recovery and the like and is suitable for large-scale industrial production of levorotation menthol.
Owner:GUANGDONG FOOD IND INST +1
Application of 1,4-dihydropyridine derivative as NO fluorescent probe
The invention relates to the field of probes, in particular to an application of a 1,4-dihydropyridine derivative as a NO fluorescent probe. According to the invention, based on the specific effect of the 1,4-dihydropyridine derivative and nitric oxide, (aromatization, resulting in the changes of electronic structure distribution and molecular conformation in the probes) features of corresponding pyridine derivatives are produced, to realize the response of the fluorescent probe to nitric oxide. Based on the changes of the fluorescence in nature before and after the detection (changes in fluorescence emission intensity, fluorescence emission wavelength, fluorescence emission service life and the like), the detection for the nitric oxide is realized.
Owner:NAT INST FOR FOOD & DRUG CONTROL
Asymmetric synthesis method of dextral citronellal
InactiveCN103724170AEasy to makeMild reaction conditionsOrganic compound preparationCarbonyl compound preparationHydrogenDihydropyridine
The invention discloses an asymmetric synthesis method of dextral citronellal. The method takes citral as a starting material, dihydropyridine derivative as a negative hydrogen source, and chiral amine salt as a chiral auxiliary agent, and asymmetric hydrogenation reaction is generated in a bi-catalytic system to synthesize dextral citronellal. By adopting the synthesis method disclosed by the invention for the synthesis of dextral citronellal, the total yield is more than 85%, and the ee (enantiomeric excess) value is greater than 80%; the synthesis method has the characteristics of mild reaction conditions, simple synthesis process, simple catalyst preparation, convenience in recycling and the like, and is suitable for industrial production of dextral citronellal.
Owner:GUANGDONG FOOD IND INST +1
1, 4-dihydropyridine bifunctional chiral catalyst and preparation method and application thereof
InactiveCN109824652AAvoid residueReduce pollutionCarboxylic acid nitrile preparationOrganic compound preparationDihydropyridineBifunctional
The invention belongs to the field of organic catalysis, and discloses a novel 1, 4-dihydropyridine bifunctional chiral catalyst and a preparation method and application thereof. The general chemicalstructure formula of the chiral catalyst is shown in formula (I) as shown in specification. According to the invention, a 1, 4-dihydropyridine derivative and a chiral tetrahydropyrrole derivative areused as raw materials, and finally, the novel 1, 4-dihydropyridine bifunctional chiral catalyst is synthesized. The method has mild synthesis reaction conditions and high yield. The operation steps are simple, safe and reliable; the catalyst is environment-friendly, and can be applied to the fields of asymmetric catalytic transfer hydrogenation, chiral fine chemical synthesis, chiral drug or drugintermediate synthesis, chiral new materials, chiral functional molecule synthesis and the like; and the application prospect is wide.
Owner:广西九圣新材料有限公司
Process of producing polymer optical waveguide
InactiveUS6800425B2Originals for photomechanical treatmentOptical waveguide light guideDihydropyridinePolymer optical waveguide
A process of producing a polymer optical waveguide, including (a) a step of forming an undercladding layer on a substrate; (b) a step of forming a photosensitive resin composition layer containing a 1,4-dihydropyridine derivative and a resin on the undercladding layer; (c) a step of irradiating a region of the photosensitive resin composition layer corresponding to a core pattern with UV light through a mask to form UV light-exposed areas and UV light-unexposed areas on the photosensitive resin composition layer; (d) a step of heating the UV light-exposed areas and UV light-unexposed areas of the photosensitive resin composition layer; and (e) a step of forming an overcladding layer on the photosensitive resin composition layer after heating.
Owner:NITTO DENKO CORP
Process of producing polymer optical waveguide
InactiveUS20040013816A1Cladded optical fibrePretreated surfacesDihydropyridinePolymer optical waveguide
Owner:NITTO DENKO CORP
Acid addition salt of optically active dihydropyridine derivative
InactiveCN101316842AExcellent blood pressure lowering effectImprove bioavailabilityOrganic active ingredientsOrganic chemistryDihydropyridineMedicine
An excellent medicine for the treatment or prevention of hypertension or the like is provided. A specific acid addition salt of (R)-2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5- pyridinedicarboxylic acid 3-(1-diphenylmethylazetidin-3- yl)ester 5-isopropyl ester is useful as a medicine for the treatment or prevention of hypertension or the like.
Owner:UBE IND LTD
Method for catalytically synthesizing 1,4-dihydropyridine derivative through cooperation of zirconocene dichloride and benzoic acid ligands
PendingCN110003093AMild reaction conditionsEasy to operateOrganic chemistryChromatographic separationBenzoic acid
The invention discloses a method for catalytically synthesizing a 1,4-dihydropyridine derivative through cooperation of zirconocene dichloride and benzoic acid ligands. According to the method, with the zirconocene dichloride as a catalyst and 3-nitrophthalic acid, 4-nitrophthalic acid, 5-methoxysalicylic acid, 5-nitrosalicylic acid, 3,5-dinitrosalicylic acid and the like as the ligands, intermolecular ring closure is performed between enamine ester and cinnamaldehyde to produce the 1,4-dihydropyridine derivative. By the method, a reaction condition is mild, the operation is simple, the reaction time is short, a reaction product is single, the atomic economy is high, and after the reaction, the 1,4-dihydropyridine derivative with wide biological activity and a high medicinal value can be obtained at a relatively high yield only through simple column chromatographic separation of the product.
Owner:SHAANXI NORMAL UNIV
Method for manufacturing optical waveguide and connecting structure of optical device
Owner:NITTO DENKO CORP
Tricyclic and tetracyclic systems with activity on the central nervous and vascular systems
The present invention relates to chemistry and pharmacy and, in particular, to the production of novel molecular entities, tricyclic and tetracyclic derivatives of benzodiazepine, pyridodiazepine and pyrimidodiazepine type fused with 1,4-dihydropyridine derivatives, having an effect on the central-nervous and vascular systems. Derivatives containing a dihydropyridine ring are used, by means of reactions with compounds of the ortho-phenylenediamine, ortho-diaminopyridine and ortho-diaminopyrimidine type, and also subsequent conversions to some thereof, to obtain tricyclic and tetracyclic derivatives of general formula I-XII that contain a diazepine or diazepinone nucleus fused to a 1,4-dihydropyridine nucleus, in which the A ring is a substituted or unsubstituted benzene, pyridine or pyrimidine ring. These molecular entities exhibit GABAergica and modulating action in the case of calcium channels which can be used in the treatment of cardiovascular, cerebrovascular, neurodegenerative, neuropsychiatric and neurological disorders.
Owner:CENT DE INVESTIGACION & DESARROLLO DE MEDICAMENTOS CIDEM +1
Preparation method for 1, 2-dihydropyridine derivative
InactiveCN103804283AEasy to operateAtom economy is highOrganic chemistryOrganic solventDihydropyridine
The invention relates to a preparation method for a 1, 2-dihydropyridine derivative, particularly a new method for preparation of the 1, 2-dihydropyridine derivative from a 3-aza-1, 5-eneyne derivative under the promotion (catalysis) of protonic acid through cyclization reaction. The method takes the 3-aza-1, 5-eneyne derivative as the raw material to generate the 1, 2-dihydropyridine derivative under two conditions. According to the condition A, alcohol is adopted as a solvent (also serving as a catalyst), other catalysts or additives are unnecessary, and reaction is carried out at a temperature ranging from room temperature to 140DEG C; or according to the condition B, alcohol, phenol or protonic acid is added into another organic solvent to serve as a catalyst. The yield of 1, 2-dihydropyridine derivative can reach up to 97%.
Owner:DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
Method of preparing 1,4-dihydrogen pyridine derivatives
InactiveCN101508672AHigh catalytic activityMild reaction conditionsOrganic chemistryOrganic-compounds/hydrides/coordination-complexes catalystsPhenyl groupPollution
The invention relates to a method for preparing 1, 4-dihydropyridine derivatives. In the presence of a resin catalyst, a compound of formula II and a compound of formula III are reacted for 1 to 36 hours at a temperature between 0 and 150 DEG C to obtain the 1, 4-dihydropyridine derivatives represented by formula I, wherein R1 is hydrogen; C1-5 is alkyl and the like; R2 is phenyl or substituted phenyl; R3 is C1-5 alkyl or C1-5 alkanoyl and the like; and X is halogen, nitryl, cyano, sulfonic alkyl or hydroxyl. The catalyst used by the method has high catalytic activity, reaction conditions are mild and separation of product is easy; the method has no environment pollution, no erosion to equipment, and simple post treatment; the catalyst can be repeatedly used and regenerated, the reaction is easy to control, and good yield can be maintained; and the prepared product has good quality, and the method is suitable for mass production, in particular for large-scale production and preparation of raw material drugs or medicine.
Owner:武汉同源药业有限公司
Oral solution of dihydropyridine derivatives
InactiveUS20180303811A1Improve stabilityCost effectiveOrganic active ingredientsDispersion deliveryDihydropyridineAntioxidant
The present invention pertains to the field of oral pharmaceutical composition of dihydropyridine derivatives. In particular, present invention relates to oral solution formulations of dihydropyridines with non-aqueous solvent and antioxidant having improved stability.
Owner:FTF PHARMA
1,4-dihydropyridine derivative with a guaiacoxypropanolamine and/or phenoxypropanolamine moiety
The invention disclosed some 1,4-dihydropiridine derivative chemically with guaiacoxypropanolamine based phenoxypropanolamine moiety and pharmacologically with beta-adrenoceptor blocking and partial beta2-agonist activities, is now emerging. The compound of 1,4-dihydropiridine derivative wherein has the formula I, wherein R selected from four group as follow R1 selected from X, H, NO2 saturated C1-C6 alkyl chain, unsaturated C6-C6 alkyl chain, R2 selected from H, CH3 R3 and R4 are individually selected from saturated C1-C6 alkyl chain, unsaturated C1-C6 alkyl chain; R5 selected from OH, saturated C1-C6 alkyl chain, unsaturated C1-C6 alkyl chain.
Owner:CHEN ING JUN
1,4- dihydropyridine derivatives with HSP modulating activity
InactiveUS20140315893A1Little and no effectReduce riskBiocideNervous disorderDiseaseProphylactic treatment
Owner:RICHTER GEDEON NYRT
Dihydropyridine derivative
ActiveCN102372692AStrong inhibitory activityLittle side effectsOrganic active ingredientsOrganic chemistryDihydropyridineTreatment hypertension
The invention belongs to the technical field of medicine, particularly relates to a dihydropyridine derivative disclosed in a general formula (I) and clinically-acceptable salt thereof, wherein R1, R2, R3, R4, R5, X or n is defined as in a specification. The invention also relates to a preparation method of the compounds and the application of the compounds in preparing medicines capable of treating hypertension.
Owner:XUANZHU BIOPHARMACEUTICAL CO LTD
Dihydropyridine derivative for treating cancer or a pre-cancerous condition and other conditions
The use of dihydropyridine-5-phosphonic acid cyclic propylene ester derivatives of formula (I), a prodrug thereof, or a pharmaceutically acceptable salt of said compound or prodrug in the treatment of cancers, pre-cancerous conditions and other conditions is disclosed, wherein each of R1-R8 are the same or different, are hydrogen or C1-C6 alkyl; one of X1 and X2 is nitro while the other is hydrogen; each of Y1 and Y2 may be the same or different, is phenyl which may be substituted by chlorine, fluorine or alkoxy; and m and n are integers from 0-4, a prodrug thereof, or a pharmaceutically acceptable salt thereof.
Owner:TAU THERAPEUTICS LLC
Positive photosensitive resin composition
InactiveUS20060199102A1Weak elasticityImprove heat resistanceRadiation applicationsPhotomechanical apparatusHydrogenDihydropyridine
A positive photosensitive resin composition comprising (A) a polyamic acid, (B) a 1,4-dihydropyridine derivative represented by the general formula (II): wherein R2 is a monovalent organic group; each of R3, R4, R5, and R6 is independently hydrogen or a monovalent organic group; and Ar—NO2 is an aromatic hydrocarbon group having a nitro group at ortho-position, and (C) an amine compound.
Owner:NITTO DENKO CORP
Dihydropyridine derivative
Dihydropyridine derivatives of the following formula, analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel. They are used as remedies for various diseases relating to the N-type calcium channel such as encephalopathies caused by the ischemia in the acute phase after the onset of cerebral infarction, cerebral hemorrhage or the like, Alzheimer's disease, etc.
Owner:AJINOMOTO CO INC
Preparation method of 2,6-pyridinedicarboxylic acid
ActiveCN110229096AThe preparation method is safeRaw materials are cheap and easy to getOrganic chemistryCarboxylic acidHydrolysis
The invention provides a preparation method of 2,6-pyridinedicarboxylic acid. The preparation method comprises the following steps: taking 1,7-pimelic acid or 1,7-pimelic acid diester (I) as a raw material to carry out a halogenation reaction to obtain 2,2,6,6-tetrahalide (II), then carrying out a cyclization reaction with ammonia to prepare a dihydropyridine derivative (III), and carrying out oxidation by an oxidizing agent or carrying out oxidation-hydrolysis to obtain the 2,6-pyridinedicarboxylic acid. According to the method disclosed by the invention, raw materials are cheap and easily available, and the preparation method is simple, is easy to implement, and is safe and environmentally friendly. The amount of wastewater is small, cost is low, the yield and selectivity are high, byproducts are fewer, and the preparation method is suitable for industrial production.
Owner:XINFA PHARMA
Dihydropyridine derivatives
Compounds having a selective N-type calcium channel antagonistic activity are provided. Dihydropyridine derivatives represented by the following formula:analogs thereof and pharmaceutically acceptable salts thereof have an activity of selectively inhibiting the action of N-type calcium channel, and they are used as therapeutic agents for various diseases relating to N-type calcium channel.
Owner:AJINOMOTO CO INC
Cationic amphiphilic 1,4-dihydropyridine derivatives useful for delivery of nucleotide containing compounds
InactiveUS20030064954A1Safe and efficientHigh transfection efficiencyBiocideOrganic chemistryDNA vaccinationDihydropyridine
The present invention discloses amphiphilic 1,4-dihydropyridine derivatives useful for the preparation of a composition for delivering nucleotide containing compounds into a target cell and / or its nucleus. Said composition comprises 1,4-dihydropyridine derivatives having a good DNA condensing capacity and capability of self-association. Also disclosed are composition comprising said derivatives complexed with nucleotide containing compounds as well methods for the producing of said complexes. The invention is also related to the use of said 1,4-dihydropyridine derivatives for manufacturing systems for delivering nucleotide containing compounds useful in gene therapy and DNA vaccination.
Owner:SPONDULI SERVICES
Photosensitive resin composition and circuit board with metal support using the same
InactiveUS8877427B2Avoid changeCuring shrinkage is smallPhotosensitive materialsSemiconductor/solid-state device manufacturingEpoxyDihydropyridine
Owner:NITTO DENKO CORP
1,4-dihydropyridine derivatives as well as preparation method and application thereof
ActiveCN107382978AGreat research valueOrganic chemistry methodsForce measurement by measuring optical property variationChemical synthesisDihydropyridine
The invention belongs to the field of organic chemical synthesis and application and relates to 1,4-dihydropyridine derivatives as well as a preparation method and an application thereof. The preparation method of the 1,4-dihydropyridine derivatives comprises the following steps: (1) preparing an initial sample of the 1,4-dihydropyridine derivatives; (2) recrystallizing the initial sample of the 1,4-dihydropyridine derivatives in different ways to obtain three different crystalline compounds I-y, I-o and I-r, wherein the step (1) comprises the following steps: (11) forming an intermediate 2 from 2,6-dimethyl-4H-pyran-4-one 1 as an initial material as well as Meldrum's acid through an addition-elimination reaction; (12) forming an intermediate 3 from the intermediate 2 and 4-dimethylaminobenzaldehyde through a condensation reaction; (13) synthesizing the initial sample of the 1,4-dihydropyridine derivatives from the intermediate 3 and ethylamine through nucleophilic substitution.
Owner:WENZHOU UNIVERSITY
Heat stabilizer composition for transparent PVC (polyvinyl chloride) and application of heat stabilizer composition
PendingCN112778575AImprove stabilityMeet environmental protection requirementsBulk chemical productionPhosphoric Acid EstersDihydropyridine
The invention discloses a heat stabilizer composition for transparent PVC (polyvinyl chloride) and application thereof. The heat stabilizer composition at least contains a dihydropyridine derivative as a main heat stabilizer; and the heat stabilizer composition further comprises an amine anti-aging agent serving as an auxiliary heat stabilizer A, a phenolic antioxidant serving as an auxiliary heat stabilizer B and a phosphite antioxidant serving as an auxiliary heat stabilizer C. The prepared PVC has excellent static thermal stability and dynamic thermal stability, and the used materials meet the environmental protection requirement and have no peculiar smell.
Owner:XUZHOU COLLEGE OF INDAL TECH
New analogs as androgen receptor and glucocorticoid receptor modulators
The present invention relates to novel dihydropyridine derivatives of formula (I): as modulators of nuclear receptors selected from androgen receptor and glucocorticoid receptor, to processes for their preparation, to pharmaceutical compositions comprising said compounds and to the use of said for manufacturing a medicament for the treatment of pathological conditions or diseases that can improveby modulation of androgen receptor and / or glucocorticoid receptor, selected from cancer, metastasizing cancers, benign prostate hyperplasia, polycystic ovary syndrome (PCOS), hair loss, hirsutism, acne, hypogonadism, muscle wasting diseases,cachexia, Cushing's syndrome, anti-psychotic drug induced weight gain, obesity, post-traumatic stress disorder and alcoholism.
Owner:ONCOSTELLAE SL
Visible light preparation method for azatraasterane compounds
The invention discloses a visible light preparation method for azatraasterane compounds, belonging to the technical field of synthesis of organic compounds. According to the azatraasterane provided bythe invention, at least one selected from X in a ring 1 and X in a ring 2 is a nitrogen atom, and the other X is a carbon atom. The method comprises the following steps: with a 1,4-dihydropyridine derivative or / and a 1,4-dihydropyrazine derivative as a reaction substrate, dissolving the reaction substrate and a visible light catalyst in a solvent, and carrying out [2+2] photocyclization reactionunder the irradiation of visible light. The method has the advantages of simple synthetic route, simple and convenient operation, high chemical selectivity, high yield, environment friendliness, conservation of energy, cleanness and the like.
Owner:BEIJING UNIV OF TECH
Preparation method and application of novel ionic beta-naphthol aldehyde Schiff base zirconium complex
ActiveCN110483563AImprove stabilityHigh catalytic activityGroup 4/14 organic compounds without C-metal linkagesOrganic-compounds/hydrides/coordination-complexes catalystsFiltrationOrganic synthesis
The invention belongs to the technical field of catalytic organic synthesis, and particularly relates to a preparation method and application of a novel ionic beta-naphthol aldehyde Schiff base zirconium complex. Zirconium atoms are coordinated with a beta-naphthol aldehyde Schiff base ligand and water molecules, and two perfluoroalkyl (aryl) sulfonic acid groups are combined with central atom zirconium through covalent bonds and ionic bonds respectively. The preparation method comprises the following steps: dissolving beta-naphthol aldehyde Schiff base zirconium dichloride in a solvent, adding a silver salt under the protection of N2, reacting the mixture for 1-4 hours in a dark place at room temperature, performing filtration, adding n-hexane into filtrate until layering, putting the solution into a refrigerator, and freezing the solution for 24 hours to separate out the beta-naphthol aldehyde Schiff base zirconium complex. The beta-naphthol aldehyde Schiff base zirconium complex hashigh air stability and strong Lewis acidity, and can efficiently catalyze the Hantzsch reaction of aldehyde, beta-ketoester and ammonium acetate to synthesize 1,4-dihydropyridine derivatives.
Owner:SHANXI MEDICAL UNIV
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