37results about How to "Strong near-infrared absorption" patented technology

The invention discloses a tin selenide nano material, a preparation method and application thereof. Tin selenide is synthesized by utilizing a simple, mild and green method, further, hydrophilic ligands are modified in an ultrasonic method and tin selenide nano-sheets with good water dispersibility are synthesized. The nano material has strong near-infrared absorption property and is capable of converting effective near-infrared laser into thermal energy; the photo-thermal conversion efficiency is up to 29.8%; meanwhile, the nano material has good photo-thermal stability and can be applied to light-heat treatment for cancer cells. Meanwhile, the nano material has big specific surface area of a two-dimensional laminated structure and higher medicine-carrying capacity; the nano medicine complex is capable of realizing medicine release effects of pH value response and photo-thermal response and can be utilized as a medicine carrier for chemotherapy of cancer cells. The nano material can be applied to photoacoustic imaging and infrared thermal imaging and realizes photo-thermal and medicine integrated treatment of imaging guidance.

The invention discloses a bimetal-doped VIB-group metal oxide nano-material, a preparation method therefor and an application of the bimetal-doped VIB-group metal oxide nano-material. A chemical formula of the VIB-group metal oxide nano-material disclosed by the invention is AxByMO3, wherein M is a VIB group element, A and B are dope elements present in the form of metal cations, O is an oxygen element, x is not smaller than 0 and not greater than 1, y is not smaller than 0 and not greater than 1, and the A and the B are one of different and self-existent main-group or subgroup elements. The metal oxide nano-material is prepared from a VIB-group metal element containing compound, a reducer and A-and-B-containing substances under hydrothermal conditions. The prepared bimetal-doped VIB-group oxide nanoparticles have very high near-infrared screening capacity and can be applied to the fields of photo-control materials and devices, glass energy saving and the like.

The invention discloses a mesoporous polydopamine liquid-state fluorine-carbon-entrapped ultrasonic contrast medium and a preparation method thereof. Through a template method, dopamine hydrochloride,a block copolymer F-127 and 1,3,5-trimethylbenzene are used as basic raw materials for preparing liquid-state fluorine-carbon-entrapped mesoporous polydopamine solution (the MPDA ultrasonic contrastmedium) with different particle diameters. The prepared mesoporous polydopamine (MPDA) has good biocompatibility and a mesoporous structure, liquid-state fluorine-carbon can enter a mesoporous pore channel, and under heating and irradiation of an ultrasonic wave, bubbles are generated to reinforce the ultrasonic contrast effect. The ultrasonic contrast medium is controllable in particle diameter,and simple in preparation method, expected to be further applied for tumor diagnosis and treatment integration after synergistically wrapped with a drug, and has a high research value and extensive application prospect.

The invention relates to an amphiphilic aza-BODIPY fluorescent dye and a preparation method thereof. The preparation method comprises the following steps: reacting p-propynyloxy acetophenone with dodecyloxy phenylacetaldehyde to obtain chalcone; performing nitromethane nitration to obtain 4'-propynyloxy-4-dodecyloxy-2-nitromethylene-chalcone; carrying out coupling under an ammonium acetate condition, reacting the coupling product with boron trifluoride-ether to obtain an aza-BODIPY structure; and introducing different hydrophilic groups into the opposite alkynes of benzene with substituted 3rd and 5th positions of the parent structure of aza-BODIPY through click reactions so as to obtain the amphiphilic molecule. The provided synthesis method has the advantages of few steps, simple conditions, and high yield. Prominent aggregation phenomenon of amphiphilic BODIPY dye in water can be observed, the UV absorption of the dye is near 800 nm, the UV absorption peak is sharp, and the strength is extremely high.

The invention discloses a preparation method of a reduced molybdenum oxide quantum dot material.The method particularly comprises the following steps that 1 g-3 g of metal molybdenum powder is dissolved in 10 ml of 30% hydrogen peroxide, under magnetic stirring, mixing is conducted till the powder is completely dissolved, 0.5 g-5 g of reducing agent is added, a crystallization reaction is conducted at 60 DEG C to 160 DEG C in a reaction kettle for 6 h to 48 h, after the reaction is finished, powder samples are centrifuged, washed and vacuum-dried, and the powder samples are obtained.According to the preparation method of the reduced molybdenum oxide quantum dot material, mixed valence state molybdenum oxide quantum dots are uniform in morphology, the size is smaller than 5 nm, and the excellent and stable near infrared absorption performance is achieved.

The invention discloses a preparation method and application of a hyaluronic acid modified ruthenium nano photo-thermal material. The preparation method comprises the following steps: firstly, enabling hyaluronic acid and cysteine hydrochloride to carry out an amidation reaction so as to obtain cysteine modified hyaluronic acid; secondly, enabling the cysteine modified hyaluronic acid to react with ruthenium chloride under reaction of sodium borohydride, thereby obtaining a water-soluble hyaluronic acid modified ruthenium nano photo-thermal material. The preparation method is easy in preparation raw material obtaining, simple in process and small in environment pollution; meanwhile, the hyaluronic acid has the property of targeting cancer cells with over-expressed CD44, so that a high-efficiency photo-thermal material with a targeting function can be prepared, and the material has an application value in cancer treatment; due to targeting photo-thermal treatment of the hyaluronic acidmodified ruthenium nano photo-thermal material, the cancer cell killing rate is increased, and the material has wide application prospects in photo-thermal treatment, functional materials, tissue engineering, and the like.

The invention discloses a room temperature aqueous phase synthesis method of multi-functional Prussian blue nanocubes. The method comprises dissolving plant polyphenol in purified water, adding a ferric ion solution into the solution, carrying out uniform mixing, slowly adding the ferrous cyanide solution into the solution drop by drop, and carrying out stirring at the room temperature for a reaction for 5-60min to obtain the Prussian blue nanocubes with uniform sizes and excellent biocompatibility and stability. Through use of the reduction and complexing effects of external plant polyphenol,the functions of the Prussian blue nanoparticles are developed so that the multi-functional Prussian blue nanocubes are obtained. Through research on the in-vitro imaging of the multi-functional Prussian blue nanocubes, the results show that the material has a good application prospect in the multi-mode bio-imaging. The method has simple and mild conditions, low energy consumption and a short preparation period, is easy to realize and is an ideal method for preparing multi-functional Prussian blue nanocubes.

The invention discloses an asymmetric near-infrared cyanine dye and a preparing method and application thereof. The structural formula of the asymmetric near-infrared cyanine dye is shown as the formula I. The preparing method of the asymmetric near-infrared cyanine dye includes the following steps that 1, a compound shown as the formula II and a compound shown as the formula III are subjected to a condensation reaction to obtain a compound shown as the formula V; 2, the compound shown as the formula V and a compound shown as the formula IV are subjected to a condensation reaction to obtain the asymmetric near-infrared cyanine dye shown as the formula I. According to the asymmetric near-infrared cyanine dye, the conjugated system is large, high near-infrared absorption is achieved, the fluorescence quantum yield is low, the probability of nonradiative jumping is large, and therefore good photo-thermal conversion efficiency is achieved; the asymmetric near-infrared cyanine dye is further wrapped with BSA with good biocompatibility, the water solubility of the dye is improved, the retention time in the body is prolonged, and the asymmetric near-infrared cyanine dye can serve as a photo-thermal therapeutic agent for photo-thermal treatment and has the very important effect in the tumor treating aspect.

The invention discloses a polydopamine-coated Prussian blue and silver-loaded nano-composite material, and a preparation method and an application thereof. The composite material is formed by coatingPrussian blue with polydopamine and then growing nano-silver on the polydopamine in situ, and the particle size of the composite material is 100-150 nm. The preparation method comprises the followingsteps: reacting potassium ferricyanide with polyvinylpyrrolidone to obtain Prussian blue, adding dopamine into a Tris-HCl solution of Prussian blue to prepare polydopamine-coated Prussian blue, and mixing and stirring the obtained polydopamine-coated Prussian blue dispersion, ammonia water, a reducing agent and a silver nitrate solution to react in order to make nano-silver grows on the coating layer polydopamine in situ in order to obtain the product. The nano-composite material has a good antibacterial effect, is not prone to causing drug resistance of bacteria, has good stability and dispersity, the preparation method has the advantages is simple and mild, short in time consumption, low in energy consumption and easy to realize large-scale production, and the nano-composite material canbe used for preparing photo-thermal antibacterial drugs or chronic traumatic infection treatment drugs.

The invention discloses phospholipid-polyaniline nanoparticles for photoacoustic imaging and / or photothermal therapy and a preparation method. The preparation method comprises the steps that 1, eigenstate polyaniline is prepared; 2, phospholipid-coated polyaniline nanoparticles are synthesized, wherein eigenstate polyaniline and sodium dodecyl benzene sulfonate are dissolved into chloroform, stirring is performed to obtain a green conductive polyaniline solution, the conductive polyaniline solution, chloroform, DPPC, DSPE-PEG2000 and FA-DSPE-PEG2000 are added into a container, ultrasonic dispersion is performed, chloroform is removed through evaporation, water is added, ultrasonic dispersion and centrifugation are performed, supernate is a clear and bright green solution, and then freeze drying is performed. The preparation method has the advantages of being simple, high in reaction controllability, low in energy dissipation and capable of easily achieving scalization and easily obtaining the raw materials; the prepared nanoparticles show the good water solubility and biocompatibility, the high near-infrared absorption performance and the good light and thermal stability and can be simultaneously used for photothermal therapy, photoacoustic imaging and infrared thermal imaging.

The invention discloses a dual-imaging-guided photothermal therapy multifunctional nano-hybrid and a preparation method. The preparation steps are: (1) preparing bismuth selenide nanoplate powder by solvent method: hyaluronic acid doped polypyrrole coated bismuth selenide Nanoplate: dissolve bismuth selenide nanoplate powder and polyvinylpyrrolidone with an average molecular weight of k13-18 in water, add pyrrole, stir, transfer to ice bath, add ferric chloride aqueous solution drop by drop, add hyaluronic acid Acid aqueous solution, reaction; dialyzed polymer solution, centrifuged, and dried precipitate, that is. The hybrid compound of the present invention has good physical stability, and exhibits good water solubility, biocompatibility, strong near-infrared absorption and good photothermal stability, and can be used for photothermal therapy guided by CT and PA imaging; Good in vivo targeting; simple preparation process, mild reaction conditions, strong reaction controllability, low toxicity, easy scale-up, readily available raw materials, and cheap prices.

The invention provides a perylene bisimide compound, the structure of the compound is shown in a formula (I), wherein, R is methoxy (-OCH3), amino (-NH2), maleic anhydride (-MAL), nitrine (-N3) or hydroxy (-OH); n represents repeating unit number of polyethylene glycol, which can be an integer between 10 and 120; f and k are respectively the integers between 1 and 50, which preferably selects the integers between 2 and 20 and most preferably between 7 and 9. The invention also provides the perylene bisimide nano particles through self assembly of the perylene bisimide compound, the size of the nano particles is adjustable, the structure is uniform, through surface modification, multi-mode imaging and multifunctional targeting are realized. The invention also provides a preparation method of the perylene bisimide compound and an application of the perylene bisimide nano particles in prepataion of a diagnostic reagent for focus parts of tumour, inflammation, thrombus and lymph system and / or a treatment medicine.

The invention relates to an amphiphilic aza-BODIPY near-infrared dye and a preparation method thereof; through molecular design, hydrophilic chain oligomeric glycol ether groups and hydrophobic chaindodecyloxy group chains with different numbers and positions are connected into 1,3,5,7-tetramethyl aza-BODIPY derivatives to regulate aza-BODIPY properties so as to research aza-BODIPY self-assemblybehaviors, and the photothermal property provides an effective synthesis method guarantee. The method has the advantages of few synthesis steps, simple reaction conditions, high product yield and stable structure. Ultraviolet absorption is carried out at 705-7XX nm in a dichloromethane solution, and red shift of ultraviolet absorption in a polar solvent is carried out to 809-8XX nm. The self-assembly has regular morphology, is expected to have high photo-thermal conversion efficiency under the action of proper near-infrared laser, and has potential application prospect as a new photo-thermal reagent.

The invention discloses a preparation method and application of molybdenum oxide nanoparticles used for targeted photo-thermal and photodynamic therapy. The nanoparticles are synthesized from hyaluronic acid, ammonium heptamolybdate and glucose through the one-step method. The method is easy and convenient to operate, and raw materials are low in price and easy to obtain. The prepared nanoparticles modified by hyaluronic acid have the advantages of being low in cell toxicity, good in biocompatibility and the like. Besides, the molybdenum oxide nanoparticles have good absorption in infrared and near-infrared areas, water solubility of the nanoparticles modified by hyaluronic acid is better, and photothermal conversion efficiency is good. The nanoparticles have photosensitization and can generate active oxygen under irradiation of infrared or near-infrared light. The prepared molybdenum oxide nanoparticles can be used for photo-thermal and photodynamic cancer treatment in a targeted mode, and have wide application prospects in the field of cancer treatment.

The invention discloses a tin selenide nano material, a preparation method and application thereof. Tin selenide is synthesized by utilizing a simple, mild and green method, further, hydrophilic ligands are modified in an ultrasonic method and tin selenide nano-sheets with good water dispersibility are synthesized. The nano material has strong near-infrared absorption property and is capable of converting effective near-infrared laser into thermal energy; the photo-thermal conversion efficiency is up to 29.8%; meanwhile, the nano material has good photo-thermal stability and can be applied to light-heat treatment for cancer cells. Meanwhile, the nano material has big specific surface area of a two-dimensional laminated structure and higher medicine-carrying capacity; the nano medicine complex is capable of realizing medicine release effects of pH value response and photo-thermal response and can be utilized as a medicine carrier for chemotherapy of cancer cells. The nano material can be applied to photoacoustic imaging and infrared thermal imaging and realizes photo-thermal and medicine integrated treatment of imaging guidance.

The invention discloses a preparation method and application of metal-polyphenol nano-particles. The preparation method comprises the following steps: weighing a certain amount of tannic acid and a certain amount of ammonium metavanadate, separately dissolving the tannic acid and the ammonium metavanadate into distilled water, and uniformly stirring for subsequent use; heating an ammonium metavanadate solution, and stirring to obtain a golden yellow solution, namely a vanadium oxide solution; adding the vanadium oxide solution in a tannic acid solution, and heating and reacting to obtain a black solution; and carrying out dialysis to obtain the final product. The product has biodegradability, and the preparation method is a novel method for preparing the metal-polyphenol nano-particles forphotothermal therapy. The preparation method is simple and convenient to operate, and the raw materials are cheap and easily obtained. The metal-polyphenol nano-particles prepared by the method not only can be absorbed well in a near-infrared region like a traditional photothermal reagent and can be used for photothermal therapy of cancers, but also particularly has biodegradability, facilitatesinternal excretion, is not residual in a living body, and has wide application prospect.

The invention provides a heptamethine indocyanine dye as well as a preparation method and an application thereof, and belongs to the technical field of fine chemical engineering. The heptamethine indocyanine dye provided by the invention has a structure as shown in a formula 1, has strong near-infrared absorption in a near-infrared region, and has good light stability and photo-thermal conversion efficiency, and the photo-thermal conversion rate and photo-thermal stability of the heptamethine indocyanine dye are obviously improved compared with indocyanine green. Meanwhile, the heptamethine indocyanine dye provided by the invention has a good fluorescence property. The heptamethine indocyanine dye disclosed by the invention belongs to small organic molecules, has low cytotoxicity and multiple chemical sites, and is easy to further design and synthesize functional molecules; and has good biocompatibility, is easy to remove in a living body, has a clear biodegradation pathway, and can be applied to the fields of biomarkers, optical imaging, photo-thermal imaging, photo-acoustic imaging, photodynamic therapy and photo-thermal therapy.

The invention discloses hyaluronic acid-copper (II) composite nanoparticles and a preparation method thereof. The copper (II) composite nanoparticles are prepared by using hyaluronic acid subjected tofiber-bridging and modification of diethylenetriamine, and copper (II) salt as raw materials. The preparation method disclosed by the invention is simple and convenient to operate, and the raw materials are cheap and easy to obtain; the hyaluronic acid modified copper (II) composite nanoparticles have targeting properties on cancer cells, good biocompatibility and lower toxic and side effects. Besides, diethylenetriamine modified hyaluronic acid-copper (II) composite nanoparticles have favorable absorption in near infrared regions, and have the possibility of photothermal conversion. The optothermal property research confirms that the hyaluronic acid-copper (II) composite nanoparticles have favorable optothermal properties. The prepared hyaluronic acid-copper (II) composite nanoparticlescan be used for optothermal treatment and have great application prospects in the field of cancer treatment.

The invention discloses a preparation method and application of a boron-doped black zirconium dioxide nanoparticle. The preparation method is characterized in that nanometer zirconium and sodium borohydride are taken as raw materials, 3-aminopropyltriethoxysilane and hyaluronic acid are adopted for modification to prepare the black zirconium dioxide nanoparticle, and the prepared black zirconium dioxide nanoparticle can enter a tumor cell to take the effect of photothermal and photodynamic therapy. The raw materials required for preparation are low in price and easily accessible. The preparation method is simple. The obtained product has favorable biocompatibility and water solubility, has strong absorption in ultraviolet, visible-light and near-infrared regions and favorable photothermalconversion efficiency, and can produce active oxygen under a light radiation condition so as to be used for photothermal and photodynamic therapy. The prepared boron-doped black zirconium dioxide nanoparticle has a wide application prospect in photothermal and photodynamic therapy.

The invention discloses a molybdenum disulfide nanodot and polyaniline nanohybrid and a preparation method and application. The preparation method comprises the steps that 1, molybdenum disulfide nanodot powder is prepared; 2, an aqueous solution of aniline and an aqueous solution of sodium dodecyl sulfate are taken and mixed to be uniform, a mixed solvent is obtained, and the molybdenum disulfide nanodot powder and povidone are added into the mixed solvent to be stirred; 3, an ammonium persulfate solution is dropwise added into liquid obtained in the second step, stirring and centrifuging are conducted, green precipitate is obtained, freeze drying is conducted, and the molybdenum disulfide nanodot and polyaniline nanohybrid is obtained. The molybdenum disulfide nanodot and polyaniline nanohybrid has water solubility and biocompatibility, can encapsulate a large quantity of molybdenum disulfide nanodots, can be used for CT imaging, displays good and high near infrared absorption and good light and thermal stability and can be used for light and thermal treatment and infrared thermal imaging simultaneously. The preparation method is simple, the reaction condition is mild, the controllability is high, energy consumption is low, large scale is easy to achieve, and the cost is low.

The invention discloses a multifunctional nanometer hybrid integrated CT imaging and phototherapy and a preparing method. The nanometer hybrid is shown through MoS2-AuNPs-Ce6, wherein MoS2 is the abbreviation of a molybdenum disulfide nano-plate modified by thiol-polyethylene glycol, AuNPs is the abbreviation of gold nano-particles modified by 2-mercaptopyridine, and Ce6 is the abbreviation of chlorine e6. The preparing technology of the nanometer hybrid MoS2-AuNPs-Ce6 is simple, reaction controllability is high, energy consumption is low, large scale is easy to achieve, raw materials for use are easy to obtain, and the price is low; the nanometer hybrid can be used for CT imaging; good water solubility and good biocompatibility are shown, high near infrared absorption and good photo-thermal stability are achieved, and the hybrid can be used for photo-thermal treatment and infrared thermal imaging at the same time; and a strong photodynamic therapy function is achieved, and an inhibiting function is achieved on tumor cells.

The invention relates to an amphiphilic aza-BODIPY fluorescent dye and a preparation method thereof. The preparation method comprises the following steps: reacting p-propynyloxy acetophenone with dodecyloxy phenylacetaldehyde to obtain chalcone; performing nitromethane nitration to obtain 4'-propynyloxy-4-dodecyloxy-2-nitromethylene-chalcone; carrying out coupling under an ammonium acetate condition, reacting the coupling product with boron trifluoride-ether to obtain an aza-BODIPY structure; and introducing different hydrophilic groups into the opposite alkynes of benzene with substituted 3rd and 5th positions of the parent structure of aza-BODIPY through click reactions so as to obtain the amphiphilic molecule. The provided synthesis method has the advantages of few steps, simple conditions, and high yield. Prominent aggregation phenomenon of amphiphilic BODIPY dye in water can be observed, the UV absorption of the dye is near 800 nm, the UV absorption peak is sharp, and the strength is extremely high.

The invention provides a heptamethine indocyanine dye and a preparation method and application thereof, belonging to the technical field of fine chemicals. The heptamethine indole cyanine dye provided by the present invention has a structure shown in formula 1, which has strong near-infrared absorption in the near-infrared region, and has good photostability and photothermal conversion efficiency. Thermal stability is significantly improved compared to indocyanine green. At the same time, the heptamethine indocyanine dye provided by the invention has good fluorescence performance. The heptamethine indole cyanine dye in the present invention belongs to small organic molecules, has low cytotoxicity and many chemical sites, and is easy to further design and synthesize functional molecules; it has good biocompatibility, is easy to remove in organisms, and has clear biodegradation The approach can be applied in the fields of biomarkers, optical imaging, photothermal imaging, photoacoustic imaging, photodynamic therapy and photothermal therapy.

The invention discloses phospholipid-polyaniline nanoparticles for photoacoustic imaging and / or photothermal therapy and a preparation method. The preparation method comprises the steps that 1, eigenstate polyaniline is prepared; 2, phospholipid-coated polyaniline nanoparticles are synthesized, wherein eigenstate polyaniline and sodium dodecyl benzene sulfonate are dissolved into chloroform, stirring is performed to obtain a green conductive polyaniline solution, the conductive polyaniline solution, chloroform, DPPC, DSPE-PEG2000 and FA-DSPE-PEG2000 are added into a container, ultrasonic dispersion is performed, chloroform is removed through evaporation, water is added, ultrasonic dispersion and centrifugation are performed, supernate is a clear and bright green solution, and then freeze drying is performed. The preparation method has the advantages of being simple, high in reaction controllability, low in energy dissipation and capable of easily achieving scalization and easily obtaining the raw materials; the prepared nanoparticles show the good water solubility and biocompatibility, the high near-infrared absorption performance and the good light and thermal stability and can be simultaneously used for photothermal therapy, photoacoustic imaging and infrared thermal imaging.

The invention discloses anano-drug delivery system for photothermal-sclerosis combined therapy, the system is characterized in that the drug delivery system is composed of a drug carrier, a hardening agent and a plant polyphenol iron complex, and is specifically prepared by coating the hardening agent and the plant polyphenol iron complex with the drug carrier. The hardening agent and the drug carrier are included through electrostatic adsorption, and the plant polyphenol iron complex is formed by complexing plant polyphenol and ferric iron Fe (III) and is coated in the drug carrier due to high surface energy. The drug delivery system provided by the invention is a photothermal-sclerosis synergistic treatment system based on nanometer co-loading, accurate drug delivery to an affected part under the guidance of photoacoustic imaging can be realized, photo-thermal treatment and sclerosis treatment are combined for application, and the treatment effect on lymphangial malformation is better.

The invention discloses an asymmetric near-infrared cyanine dye and a preparing method and application thereof. The structural formula of the asymmetric near-infrared cyanine dye is shown as the formula I. The preparing method of the asymmetric near-infrared cyanine dye includes the following steps that 1, a compound shown as the formula II and a compound shown as the formula III are subjected to a condensation reaction to obtain a compound shown as the formula V; 2, the compound shown as the formula V and a compound shown as the formula IV are subjected to a condensation reaction to obtain the asymmetric near-infrared cyanine dye shown as the formula I. According to the asymmetric near-infrared cyanine dye, the conjugated system is large, high near-infrared absorption is achieved, the fluorescence quantum yield is low, the probability of nonradiative jumping is large, and therefore good photo-thermal conversion efficiency is achieved; the asymmetric near-infrared cyanine dye is further wrapped with BSA with good biocompatibility, the water solubility of the dye is improved, the retention time in the body is prolonged, and the asymmetric near-infrared cyanine dye can serve as a photo-thermal therapeutic agent for photo-thermal treatment and has the very important effect in the tumor treating aspect.

The invention discloses a modified vanadium carbide nanodot for chemical power and photo-thermal synergistic antibiosis as well as a preparation method and application thereof, and the modified vanadium carbide nanodot is a stabilizer modified vanadium carbide nanodot with the size of 1-4 nm. The nano preparation disclosed by the invention has chemical kinetic characteristics and can be converted into high-toxicity active oxygen hydroxyl radicals under the action of hydrogen peroxide molecules in a body; meanwhile, due to high photothermal conversion efficiency, the preparation can cooperate with photothermal and chemical power, and effective treatment on bacteria such as gram-negative bacteria and gram-positive bacteria is achieved.

The invention discloses an ultrasonic contrast agent containing liquid fluorocarbon in mesoporous polydopamine and a preparation method thereof. Mesoporous polydopamine solutions (MPDA ultrasound contrast agents) with different particle sizes loaded with liquid fluorocarbons were prepared by template method using dopamine hydrochloride, block copolymer F-127 and 1,3,5-trimethylbenzene as basic raw materials . The mesoporous polydopamine (MPDA) prepared by the invention has excellent biocompatibility and mesoporous structure, and liquid fluorocarbons can enter into the mesoporous channels, and under heating and ultrasonic irradiation, bubbles are generated to enhance the ultrasound contrast effect. The particle size of the ultrasonic contrast agent is controllable, and the preparation method is simple. Co-packaging with drugs is expected to be further applied to the integration of tumor diagnosis and treatment, and has high research value and broad application prospects.

The invention discloses a preparation method and application of metal-polyphenol nano-particles. The preparation method comprises the following steps: weighing a certain amount of tannic acid and a certain amount of ammonium metavanadate, separately dissolving the tannic acid and the ammonium metavanadate into distilled water, and uniformly stirring for subsequent use; heating an ammonium metavanadate solution, and stirring to obtain a golden yellow solution, namely a vanadium oxide solution; adding the vanadium oxide solution in a tannic acid solution, and heating and reacting to obtain a black solution; and carrying out dialysis to obtain the final product. The product has biodegradability, and the preparation method is a novel method for preparing the metal-polyphenol nano-particles forphotothermal therapy. The preparation method is simple and convenient to operate, and the raw materials are cheap and easily obtained. The metal-polyphenol nano-particles prepared by the method not only can be absorbed well in a near-infrared region like a traditional photothermal reagent and can be used for photothermal therapy of cancers, but also particularly has biodegradability, facilitatesinternal excretion, is not residual in a living body, and has wide application prospect.