37results about How to "Strong near-infrared absorption" patented technology

The invention discloses a tin selenide nano material, a preparation method and application thereof. Tin selenide is synthesized by utilizing a simple, mild and green method, further, hydrophilic ligands are modified in an ultrasonic method and tin selenide nano-sheets with good water dispersibility are synthesized. The nano material has strong near-infrared absorption property and is capable of converting effective near-infrared laser into thermal energy; the photo-thermal conversion efficiency is up to 29.8%; meanwhile, the nano material has good photo-thermal stability and can be applied to light-heat treatment for cancer cells. Meanwhile, the nano material has big specific surface area of a two-dimensional laminated structure and higher medicine-carrying capacity; the nano medicine complex is capable of realizing medicine release effects of pH value response and photo-thermal response and can be utilized as a medicine carrier for chemotherapy of cancer cells. The nano material can be applied to photoacoustic imaging and infrared thermal imaging and realizes photo-thermal and medicine integrated treatment of imaging guidance.

The invention discloses a molybdenum disulfide nanodot and polyaniline nanohybrid and a preparation method and application. The preparation method comprises the steps that 1, molybdenum disulfide nanodot powder is prepared; 2, an aqueous solution of aniline and an aqueous solution of sodium dodecyl sulfate are taken and mixed to be uniform, a mixed solvent is obtained, and the molybdenum disulfide nanodot powder and povidone are added into the mixed solvent to be stirred; 3, an ammonium persulfate solution is dropwise added into liquid obtained in the second step, stirring and centrifuging are conducted, green precipitate is obtained, freeze drying is conducted, and the molybdenum disulfide nanodot and polyaniline nanohybrid is obtained. The molybdenum disulfide nanodot and polyaniline nanohybrid has water solubility and biocompatibility, can encapsulate a large quantity of molybdenum disulfide nanodots, can be used for CT imaging, displays good and high near infrared absorption and good light and thermal stability and can be used for light and thermal treatment and infrared thermal imaging simultaneously. The preparation method is simple, the reaction condition is mild, the controllability is high, energy consumption is low, large scale is easy to achieve, and the cost is low.

The invention discloses a multifunctional nanometer hybrid integrated CT imaging and phototherapy and a preparing method. The nanometer hybrid is shown through MoS2-AuNPs-Ce6, wherein MoS2 is the abbreviation of a molybdenum disulfide nano-plate modified by thiol-polyethylene glycol, AuNPs is the abbreviation of gold nano-particles modified by 2-mercaptopyridine, and Ce6 is the abbreviation of chlorine e6. The preparing technology of the nanometer hybrid MoS2-AuNPs-Ce6 is simple, reaction controllability is high, energy consumption is low, large scale is easy to achieve, raw materials for use are easy to obtain, and the price is low; the nanometer hybrid can be used for CT imaging; good water solubility and good biocompatibility are shown, high near infrared absorption and good photo-thermal stability are achieved, and the hybrid can be used for photo-thermal treatment and infrared thermal imaging at the same time; and a strong photodynamic therapy function is achieved, and an inhibiting function is achieved on tumor cells.

The invention relates to an amphiphilic aza-BODIPY fluorescent dye and a preparation method thereof. The preparation method comprises the following steps: reacting p-propynyloxy acetophenone with dodecyloxy phenylacetaldehyde to obtain chalcone; performing nitromethane nitration to obtain 4'-propynyloxy-4-dodecyloxy-2-nitromethylene-chalcone; carrying out coupling under an ammonium acetate condition, reacting the coupling product with boron trifluoride-ether to obtain an aza-BODIPY structure; and introducing different hydrophilic groups into the opposite alkynes of benzene with substituted 3rd and 5th positions of the parent structure of aza-BODIPY through click reactions so as to obtain the amphiphilic molecule. The provided synthesis method has the advantages of few steps, simple conditions, and high yield. Prominent aggregation phenomenon of amphiphilic BODIPY dye in water can be observed, the UV absorption of the dye is near 800 nm, the UV absorption peak is sharp, and the strength is extremely high.

The invention provides a heptamethine indocyanine dye and a preparation method and application thereof, belonging to the technical field of fine chemicals. The heptamethine indole cyanine dye provided by the present invention has a structure shown in formula 1, which has strong near-infrared absorption in the near-infrared region, and has good photostability and photothermal conversion efficiency. Thermal stability is significantly improved compared to indocyanine green. At the same time, the heptamethine indocyanine dye provided by the invention has good fluorescence performance. The heptamethine indole cyanine dye in the present invention belongs to small organic molecules, has low cytotoxicity and many chemical sites, and is easy to further design and synthesize functional molecules; it has good biocompatibility, is easy to remove in organisms, and has clear biodegradation The approach can be applied in the fields of biomarkers, optical imaging, photothermal imaging, photoacoustic imaging, photodynamic therapy and photothermal therapy.

The invention discloses a preparation method and application of molybdenum oxide nanoparticles used for targeted photo-thermal and photodynamic therapy. The nanoparticles are synthesized from hyaluronic acid, ammonium heptamolybdate and glucose through the one-step method. The method is easy and convenient to operate, and raw materials are low in price and easy to obtain. The prepared nanoparticles modified by hyaluronic acid have the advantages of being low in cell toxicity, good in biocompatibility and the like. Besides, the molybdenum oxide nanoparticles have good absorption in infrared and near-infrared areas, water solubility of the nanoparticles modified by hyaluronic acid is better, and photothermal conversion efficiency is good. The nanoparticles have photosensitization and can generate active oxygen under irradiation of infrared or near-infrared light. The prepared molybdenum oxide nanoparticles can be used for photo-thermal and photodynamic cancer treatment in a targeted mode, and have wide application prospects in the field of cancer treatment.

The invention discloses phospholipid-polyaniline nanoparticles for photoacoustic imaging and / or photothermal therapy and a preparation method. The preparation method comprises the steps that 1, eigenstate polyaniline is prepared; 2, phospholipid-coated polyaniline nanoparticles are synthesized, wherein eigenstate polyaniline and sodium dodecyl benzene sulfonate are dissolved into chloroform, stirring is performed to obtain a green conductive polyaniline solution, the conductive polyaniline solution, chloroform, DPPC, DSPE-PEG2000 and FA-DSPE-PEG2000 are added into a container, ultrasonic dispersion is performed, chloroform is removed through evaporation, water is added, ultrasonic dispersion and centrifugation are performed, supernate is a clear and bright green solution, and then freeze drying is performed. The preparation method has the advantages of being simple, high in reaction controllability, low in energy dissipation and capable of easily achieving scalization and easily obtaining the raw materials; the prepared nanoparticles show the good water solubility and biocompatibility, the high near-infrared absorption performance and the good light and thermal stability and can be simultaneously used for photothermal therapy, photoacoustic imaging and infrared thermal imaging.

The invention discloses an ultrasonic contrast agent containing liquid fluorocarbon in mesoporous polydopamine and a preparation method thereof. Mesoporous polydopamine solutions (MPDA ultrasound contrast agents) with different particle sizes loaded with liquid fluorocarbons were prepared by template method using dopamine hydrochloride, block copolymer F-127 and 1,3,5-trimethylbenzene as basic raw materials . The mesoporous polydopamine (MPDA) prepared by the invention has excellent biocompatibility and mesoporous structure, and liquid fluorocarbons can enter into the mesoporous channels, and under heating and ultrasonic irradiation, bubbles are generated to enhance the ultrasound contrast effect. The particle size of the ultrasonic contrast agent is controllable, and the preparation method is simple. Co-packaging with drugs is expected to be further applied to the integration of tumor diagnosis and treatment, and has high research value and broad application prospects.

The invention discloses a preparation method and application of metal-polyphenol nano-particles. The preparation method comprises the following steps: weighing a certain amount of tannic acid and a certain amount of ammonium metavanadate, separately dissolving the tannic acid and the ammonium metavanadate into distilled water, and uniformly stirring for subsequent use; heating an ammonium metavanadate solution, and stirring to obtain a golden yellow solution, namely a vanadium oxide solution; adding the vanadium oxide solution in a tannic acid solution, and heating and reacting to obtain a black solution; and carrying out dialysis to obtain the final product. The product has biodegradability, and the preparation method is a novel method for preparing the metal-polyphenol nano-particles forphotothermal therapy. The preparation method is simple and convenient to operate, and the raw materials are cheap and easily obtained. The metal-polyphenol nano-particles prepared by the method not only can be absorbed well in a near-infrared region like a traditional photothermal reagent and can be used for photothermal therapy of cancers, but also particularly has biodegradability, facilitatesinternal excretion, is not residual in a living body, and has wide application prospect.