Room temperature aqueous phase synthesis method of multi-functional Prussian blue nanocubes

A technology of nanocube and Prussian blue, which is applied in the field of multifunctional Prussian blue nanocube and its synthesis, can solve the problems of complex preparation process, short preparation cycle, and long preparation cycle, and achieve simple preparation process, short preparation cycle and low material cost. Poison effect

Inactive Publication Date: 2018-06-15
NANJING UNIV OF POSTS & TELECOMM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] Technical problem to be solved: In order to overcome the deficiencies in the prior art, this application proposes a room temperature aqueous phase synthesis method of multifunctional Prussian blue nanocubes, which is green, convenient and easy to operate, and the obtained multifunctional Prussian blue nano The size of the cube is uniform, the preparation process is simple, the number of equipment is small, the preparation cycle is short, the energy consumption is low, the environment is friendly, and it is easy to promote, and solves the technical problems of complex preparation process, long preparation cycle and high energy consumption in the prior art

Method used

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Embodiment 1

[0038] Such as figure 1 Shown, a room temperature aqueous phase synthesis method of multifunctional Prussian blue nanocubes, comprising the following steps:

[0039] Step 1: At room temperature, weigh tannic acid and dissolve it in 40 mL of purified water, stir and dissolve at room temperature to obtain a 0.1 mM aqueous solution of tannic acid;

[0040] The second step: adding the ferric chloride solution to the tannic acid aqueous solution obtained in the first step, stirring and mixing at room temperature to obtain a tannic acid solution with a concentration of 0.5 mM ferric chloride;

[0041] Step 3: Add 0.5 mM potassium ferrocyanide solution dropwise to the tannic acid solution of 0.5 mM ferric chloride prepared in the second step, stir rapidly at room temperature, and the stirring reaction speed is 800r / min to obtain Tannic acid solution of ferrocyanide and ferric ion;

[0042] The fourth step: react the mixed solution obtained in the third step for 30 minutes under stirr...

Embodiment 2

[0046] Such as figure 2 Shown, a room temperature aqueous phase synthesis method of multifunctional Prussian blue nanocubes, comprising the following steps:

[0047] Step 1: At room temperature, weigh tannic acid and dissolve it in 40 mL of purified water, stir and dissolve at room temperature to obtain a 0.1 mM aqueous solution of tannic acid;

[0048] The second step: adding the ferric chloride solution to the tannic acid aqueous solution obtained in the first step, stirring and mixing at room temperature to obtain a tannic acid solution with a concentration of 0.5 mM ferric chloride;

[0049] Step 3: Add 0.5 mM potassium ferrocyanide solution dropwise to the tannic acid solution of 0.5 mM ferric chloride prepared in the second step, stir rapidly at room temperature, and the stirring reaction speed is 800r / min to obtain Tannic acid solution of ferricyanide and ferric ions;

[0050] The fourth step: react the mixed solution obtained in the third step for 30 min under stirr...

Embodiment 3

[0054] A room temperature aqueous phase synthesis method of multifunctional Prussian blue nano cubes, comprising the following steps:

[0055] Step 1: Dissolve gallic acid in 40 mL of purified water at room temperature, stir and dissolve at room temperature to obtain 0.1 mM gallic acid aqueous solution;

[0056] The second step: adding the ferric chloride solution to the gallic acid aqueous solution obtained in the first step, stirring and mixing at room temperature to obtain a gallic acid solution with a concentration of 0.5 mM ferric chloride;

[0057] Step 3: Add 0.5 mM potassium ferrocyanide solution dropwise to the gallic acid solution of 0.5 mM ferric chloride prepared in the second step, stir rapidly at room temperature, and the stirring reaction speed is 800r / min to obtain Gallic acid solution of cyanide and ferric ions;

[0058] The fourth step: react the mixed solution obtained in the third step for 30 min under stirring at room temperature, the stirring reaction sp...

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Abstract

The invention discloses a room temperature aqueous phase synthesis method of multi-functional Prussian blue nanocubes. The method comprises dissolving plant polyphenol in purified water, adding a ferric ion solution into the solution, carrying out uniform mixing, slowly adding the ferrous cyanide solution into the solution drop by drop, and carrying out stirring at the room temperature for a reaction for 5-60min to obtain the Prussian blue nanocubes with uniform sizes and excellent biocompatibility and stability. Through use of the reduction and complexing effects of external plant polyphenol,the functions of the Prussian blue nanoparticles are developed so that the multi-functional Prussian blue nanocubes are obtained. Through research on the in-vitro imaging of the multi-functional Prussian blue nanocubes, the results show that the material has a good application prospect in the multi-mode bio-imaging. The method has simple and mild conditions, low energy consumption and a short preparation period, is easy to realize and is an ideal method for preparing multi-functional Prussian blue nanocubes.

Description

technical field [0001] The invention belongs to the technical field of preparation of nanometer imaging probes, and in particular relates to a multifunctional Prussian blue nanocube and a synthesis method thereof. Background technique [0002] Plant polyphenols are polymer compounds containing polyphenolic hydroxyl groups. Because its molecular structure contains many phenolic hydroxyl groups, it can undergo complexation reactions with various metal ions. In addition, plant polyphenols are widely used in medicine due to their ability to react with proteins, alkaloids, polysaccharides, etc. in the body and their antioxidant properties. Plant polyphenols have many biological functions, such as antibacterial, antimutagenic, antiviral, anticancer, anti-inflammatory, analgesic, self-balance, etc. The high reactivity of its free radicals makes it important in chronic and degenerative diseases such as allergies, diabetes, Parkinson's disease, Alzheimer's disease, cancer and car...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/22A61K49/18A61K49/10A61K49/04A61K41/00A61P35/00
CPCA61K41/0052A61K49/04A61K49/101A61K49/18A61K49/222
Inventor 沈清明吴晨晖管慧文范曲立黄维
Owner NANJING UNIV OF POSTS & TELECOMM
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