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Hyaluronic acid-copper (II) composite nanoparticles and preparation method thereof

A technology of composite nanoparticles and hyaluronic acid, which is applied in wave energy or particle radiation treatment materials, drug combinations, pharmaceutical formulations, etc., can solve problems such as difficult formation of coordination, and achieve cheap raw materials, strong near-infrared absorption, good The effect of near-infrared absorption

Active Publication Date: 2020-02-07
GUANGXI NORMAL UNIV
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Problems solved by technology

However, the coordination of hyaluronic acid and cupric ions at the molecular level is difficult to form

Method used

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  • Hyaluronic acid-copper (II) composite nanoparticles and preparation method thereof
  • Hyaluronic acid-copper (II) composite nanoparticles and preparation method thereof

Examples

Experimental program
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Embodiment

[0029] Prepare hyaluronic acid-copper (II) composite nanoparticles, comprising the steps of:

[0030] 1) Weigh 1.613 g (4 mmol) of hyaluronic acid (HA), transfer it to a beaker, then add 100 mL of secondary water and stir to fully dissolve, take 1 mL;

[0031] 2) Add 0.38 g (2 mmol) of 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS) in step 1) 0.23 g (2 mmol) was stirred and activated for 3 hours;

[0032] 3) Add 0.4 g (2 mmol) of diethylenetriamine to the activation solution obtained in step 2) and stir for 24 hours;

[0033] 4) The solution obtained in step 3) was dialyzed with a dialysis bag with a molecular weight of 3000 Da for 48 h and then freeze-dried to obtain the hyaluronic acid diethylenetriamine ligand;

[0034] 5) Preparation of CuCL 2 Ion mother solution, take CuCl 2 26.5 mg was dissolved in 5 mL of secondary water, and 1 mL was pipetted with a pipette gun;

[0035] 6) Prepare the sample according to the mola...

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Abstract

The invention discloses hyaluronic acid-copper (II) composite nanoparticles and a preparation method thereof. The copper (II) composite nanoparticles are prepared by using hyaluronic acid subjected tofiber-bridging and modification of diethylenetriamine, and copper (II) salt as raw materials. The preparation method disclosed by the invention is simple and convenient to operate, and the raw materials are cheap and easy to obtain; the hyaluronic acid modified copper (II) composite nanoparticles have targeting properties on cancer cells, good biocompatibility and lower toxic and side effects. Besides, diethylenetriamine modified hyaluronic acid-copper (II) composite nanoparticles have favorable absorption in near infrared regions, and have the possibility of photothermal conversion. The optothermal property research confirms that the hyaluronic acid-copper (II) composite nanoparticles have favorable optothermal properties. The prepared hyaluronic acid-copper (II) composite nanoparticlescan be used for optothermal treatment and have great application prospects in the field of cancer treatment.

Description

technical field [0001] The invention relates to copper composite nanoparticles, in particular to a preparation method and application of diethylenetriamine-modified hyaluronic acid-copper (II) composite nanoparticles. Background technique [0002] Copper-containing photothermal materials, as one of the most popular research directions in photothermal therapy, still need further research. At present, copper-containing photothermal materials are mainly inorganic photothermal materials. For example: Copper-based semiconductor nanomaterials, CuS, Cu 3 BY 3 Wait. However, these inorganic photothermal materials often have some shortcomings in experimental research. For example: toxic reactions induced by semiconducting carbon materials, poor biocompatibility, and long-term toxicity. [0003] Hyaluronic acid, a natural biopolysaccharide, is widely used in the design of biomaterials. In tumor therapy, hyaluronic acid can be used as a precise delivery carrier for functional sma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/36A61P35/00C08B37/08
CPCA61K41/0052A61K47/36A61P35/00C08B37/0072
Inventor 沈星灿蒋邦平郭政玺朱成元杨爱佳
Owner GUANGXI NORMAL UNIV
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