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Targeted nano-drug delivery system for photothermal-sclerosis combined therapy

A delivery system and combined therapy technology, applied in the field of biomedicine, can solve the problems of embolism, extravasation, soft tissue injury, systemic venous return path, etc.

Active Publication Date: 2021-09-21
BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Those skilled in the art are aware that local injection of sclerosing agents carries the risk of extravasation, which can lead to localized soft tissue injury or embolization of systemic venous return pathways

Method used

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  • Targeted nano-drug delivery system for photothermal-sclerosis combined therapy
  • Targeted nano-drug delivery system for photothermal-sclerosis combined therapy
  • Targeted nano-drug delivery system for photothermal-sclerosis combined therapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Preparation of TA-BLM of Example 1 HA-Fe (Ⅲ) Embodiment

[0043] The HA (20 mM, 1 mL) was mixed with TA (5 mM, 1 mL) was dissolved in a neutral ultrapure water was added dropwise under magnetic stirring FeCl 3 Solution (100 mM, 250 μL), stirred for 10min, stirring continued BLM was added dropwise a solution state (20 mM, 300 μL), after purification by ultrafiltration magnetic stirring 1 h, to give the product HA-Fe (Ⅲ) TA-BLM.

Embodiment 2

[0044] Preparation Example 2 HA-Fe (Ⅲ) TA-PYM embodiment

[0045] The HA (20 mM, 1 mL) was mixed with TA (5 mM, 1 mL) was dissolved in a neutral ultrapure water was added dropwise under magnetic stirring FeCl 3 Solution (100 mM, 250 μL), stirred for 10min, stirring continued PYM added dropwise a solution state (20 mM, 300 μL), after purification by ultrafiltration magnetic stirring 1 h, to give the product HA-Fe (Ⅲ) TA-PYM.

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Abstract

The invention discloses anano-drug delivery system for photothermal-sclerosis combined therapy, the system is characterized in that the drug delivery system is composed of a drug carrier, a hardening agent and a plant polyphenol iron complex, and is specifically prepared by coating the hardening agent and the plant polyphenol iron complex with the drug carrier. The hardening agent and the drug carrier are included through electrostatic adsorption, and the plant polyphenol iron complex is formed by complexing plant polyphenol and ferric iron Fe (III) and is coated in the drug carrier due to high surface energy. The drug delivery system provided by the invention is a photothermal-sclerosis synergistic treatment system based on nanometer co-loading, accurate drug delivery to an affected part under the guidance of photoacoustic imaging can be realized, photo-thermal treatment and sclerosis treatment are combined for application, and the treatment effect on lymphangial malformation is better.

Description

Technical field [0001] The present invention is in the field of biomedicine, in particular to a light-heat - preparation method and application system and curing nano combination therapy targeted drug delivery. Background technique [0002] Vascular malformation is the most common soft tissue of human benign tumors or congenital malformations, in particular, occur in infants and young children, often violated facial skin, causing facial deformity and dysfunction, and secondary infection and bleeding, physical and mental health against humanity one of the important diseases. Currently, clinically used for the treatment of vascular diseases: surgery, laser therapy, sclerotherapy, radiofrequency ablation and transcatheter embolization. Wherein sclerotherapy are conservative treatment has better clinical therapeutic effects, such as bleomycin, bleomycin, etc. hardener is a first-line drug in current clinical. However, to date treatment, vascular disease remains a big challenge, a sin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/61A61K47/69A61K41/00A61K38/14A61P35/00A61P9/14A61K49/22
CPCA61K47/61A61K47/6939A61K41/0052A61K38/14A61P35/00A61P9/14A61K49/221A61K49/225A61K2300/00
Inventor 倪鑫张欣侯毅邰隽王生才郭永丽岳赛赛梁晓龙张沛森陈俊张杰张雪溪
Owner BEIJING CHILDRENS HOSPITAL AFFILIATED TO CAPITAL MEDICAL UNIV
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