Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Preparation method and application of molybdenum oxide nanoparticles used for targeted photo-thermal and photodynamic therapy

A technology of photodynamic therapy and nanoparticles, which is applied in the field of photodynamic therapy materials and photothermal, and can solve the problems of molybdenum oxide nanoparticles without targeted modification, blindness of photothermal therapy, and failure of molybdenum oxide nanoparticles to accurately reach cancer cells. Cell location and other issues, to achieve good photodynamic effect, good near-infrared absorption, good photothermal conversion efficiency and photothermal stability

Active Publication Date: 2016-12-07
GUANGXI NORMAL UNIV
View PDF5 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, the synthesis of multifunctional molybdenum oxide nanoparticles has made great progress, but most of the synthesized molybdenum oxide nanoparticles have not been targetedly modified, which makes it impossible for the molybdenum oxide nanoparticles to reach accurately during the application process. The location of cancer cells, the process of photothermal therapy is blind
At the same time, the photodynamics of molybdenum oxide nanoparticles have not been reported yet.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1) Weigh 0.4g of hyaluronic acid, 0.48g of ammonium heptamolybdate, and 0.9g of glucose, add 15mL of water, and stir to dissolve completely into a transparent liquid;

[0028] 2) Add 4 drops of concentrated hydrochloric acid with a 3mL disposable dropper, heat the oil bath to 90°C, and react for 6 hours to obtain a dark blue solution;

[0029] 3) Add dehydrated ethanol, then centrifuge with a centrifuge at a centrifugal speed of 10000r / min, and centrifuge for 10min; the amount of dehydrated ethanol added is: the volume ratio of dehydrated ethanol to the blue solution is 2:1;

[0030] 4) Wash the solid obtained in step 3) several times with water, add absolute ethanol, and centrifuge to obtain a dark blue solid;

[0031] 5) Vacuum drying is used to obtain the hyaluronic acid-modified molybdenum oxide nanoparticles of the present invention.

Embodiment 2

[0033] 1) Weigh 0.4g of hyaluronic acid, 0.48g of ammonium heptamolybdate, and 0.9g of glucose, add 10mL of water, and stir to dissolve completely into a transparent liquid;

[0034] 2) Add 3 drops of concentrated hydrochloric acid with a 3 mL disposable dropper, heat the oil bath to 90°C, and react for 6 hours to obtain a dark blue solution;

[0035] 3) Add dehydrated ethanol, then centrifuge with a centrifuge at a centrifugal speed of 10000r / min, and centrifuge for 10min; the amount of dehydrated ethanol added is: the volume ratio of dehydrated ethanol to the blue solution is 2:1;

[0036] 4) Wash the solid obtained in 3) several times with water, add absolute ethanol, and centrifuge to obtain a dark blue solid;

[0037] 5) Vacuum drying is used to obtain the hyaluronic acid-modified molybdenum oxide nanoparticles of the present invention.

Embodiment 3

[0039] 1) Weigh 0.8g of hyaluronic acid, 0.96g of ammonium heptamolybdate, and 1.8g of glucose, add 15mL of water, and stir to dissolve completely into a transparent liquid;

[0040] 2) Add 4 drops of concentrated hydrochloric acid with a 3mL disposable dropper, heat the oil bath to 90°C, and react for 6 hours to obtain a dark blue solution;

[0041] 3) Add dehydrated ethanol, then centrifuge with a centrifuge at a centrifugal speed of 10000r / min, and centrifuge for 10min; the amount of dehydrated ethanol added is: the volume ratio of dehydrated ethanol to the blue solution is 2:1;

[0042] 4) Wash the solid obtained in 3) several times with water, add absolute ethanol, and centrifuge to obtain a dark blue solid;

[0043] 5) Vacuum drying is used to obtain the hyaluronic acid-modified molybdenum oxide nanoparticles of the present invention;

[0044] The products prepared in Examples 1, 2, and 3 can all be well dispersed in aqueous solution and can exist stably.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a preparation method and application of molybdenum oxide nanoparticles used for targeted photo-thermal and photodynamic therapy. The nanoparticles are synthesized from hyaluronic acid, ammonium heptamolybdate and glucose through the one-step method. The method is easy and convenient to operate, and raw materials are low in price and easy to obtain. The prepared nanoparticles modified by hyaluronic acid have the advantages of being low in cell toxicity, good in biocompatibility and the like. Besides, the molybdenum oxide nanoparticles have good absorption in infrared and near-infrared areas, water solubility of the nanoparticles modified by hyaluronic acid is better, and photothermal conversion efficiency is good. The nanoparticles have photosensitization and can generate active oxygen under irradiation of infrared or near-infrared light. The prepared molybdenum oxide nanoparticles can be used for photo-thermal and photodynamic cancer treatment in a targeted mode, and have wide application prospects in the field of cancer treatment.

Description

technical field [0001] The invention relates to photothermal and photodynamic therapy materials, in particular to a preparation method and application of molybdenum oxide nanoparticles with targeted photothermal and photodynamic therapy functions. Background technique [0002] Photothermal therapy for tumors (Photothermal therapy, PTT) is a therapy that converts light energy into heat energy through photothermal conversion agents to bring tumor tissue to a certain temperature and kill cancer cells. Photodynamic therapy (Photodynamic therapy, PDT) is a new cancer treatment method in which photodynamic reagents generate reactive oxygen species under laser irradiation, thereby increasing the level of reactive oxygen species in tumor tissue, and then killing cancer cells. Compared with traditional surgical treatment, chemotherapy and radiotherapy, PTT and PDT have the advantages of minimal trauma, low toxicity, and repeatable treatment. Therefore, these two therapies are promis...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K9/51A61K47/48A61P35/00
CPCA61K9/5161A61K41/0052A61K41/0057
Inventor 蒋邦平王源源沈星灿周波韦方棉
Owner GUANGXI NORMAL UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com