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A kind of tin selenide nano material and its preparation method and application

A nanomaterial, tin selenide technology, applied in the field of nanomaterial preparation and biomedicine, can solve the problems of complicated surface functionalization operation, high requirements for synthesis operation, inconvenient synthesis, etc. Conversion ability, simple and mild effect of preparation process

Inactive Publication Date: 2017-01-25
FUZHOU UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] So far, the methods for synthesizing tin selenide nanosheets reported in the literature generally require the participation of organic and inorganic sources such as oleylamine at high temperatures or the use of organic selenium sources, which makes the synthesis operation demanding, inconvenient, or high in cost. For biomedicine, cumbersome surface functionalization operations are required, which limits the further application of these methods in biomedicine

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  • A kind of tin selenide nano material and its preparation method and application
  • A kind of tin selenide nano material and its preparation method and application
  • A kind of tin selenide nano material and its preparation method and application

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Embodiment 1

[0037] Preparation of tin selenide nanomaterials:

[0038] Reaction solution A: Weigh 0.040g of selenium powder, add it to 10 ml of ultrapure water, then weigh 5.00 g of sodium hydroxide and add it to the selenium powder solution, stir magnetically at a medium speed until the selenium powder dissolves, during this process Due to the exothermic process of sodium hydroxide dissolution, the temperature of the solution rises to accelerate the dissolution of the selenium powder, and the final solution is wine red. Reaction solution B: Weigh 2.00 g of citric acid and fully dissolve it in 1 ml of ultrapure water, then weigh 0.21 g of tin dichloride dihydrate (SnCl 2 2H 2 O) Add to citric acid solution for ultrasonic dissolution. Under the condition of rapid stirring, take the reaction solution B and add it dropwise to the reaction solution A, the solution gradually becomes lighter from wine red to colorless to brown to brownish black, and sinks in the form of flocs. This process i...

Embodiment 2

[0041] Test the photothermal heating curve of tin selenide nanosheet solution: take 1 ml of tin selenide nanosheet solution to a constant quartz cuvette (optical path 1cm, area 1cm 2), the solution was irradiated with an 808 nm laser and the temperature change was recorded simultaneously. Using a temperature monitor equipped with a thermocouple microprobe (φ = 0.5 mm), immerse the microprobe in the solution in a position that avoids direct laser light and touches the bottom of the cuvette Or on the side, record the temperature of the solution every 1s through the connection software. Test the photothermal heating curve of different concentrations of tin selenide nanosheet solutions: prepare different concentrations (0-80μg·mL -1 ) tin selenide nanosheet solution, adjust the laser power density to 2 W cm -2 , measuring the temperature change curve of the solution between 0 and 600 seconds under the irradiation of 808 nm laser. Such as Figure 4 Shown is the photothermal hea...

Embodiment 3

[0043] HepG2 cells were used to examine the cytotoxicity of tin selenide nanosheets: the relative activity of cells was tested by the CCK-8 method. Specifically, HepG2 cells in exponential growth phase (approximately 1×10 4 Each well) was inoculated in 96-well plates and incubated in 100 μL of cell culture medium (RPMI-1640 medium containing 10% fetal bovine serum, 1% penicillin and 1% streptomycin) at 37 °C with 5% CO 2 Humidified atmosphere cell culture incubator for 24 hours. Afterwards, the culture medium was taken out, and 100 μL of cell culture medium containing different concentrations of tin selenide nanosheets was added, each concentration was paralleled three times, and the incubation was continued for 24 hours. After pipetting the culture medium, wash it twice with phosphate buffered saline, refer to the instructions of the CCK-8 kit, add 100 uL culture medium and 10 uL CCK-8 solution to each well (culture volume 10% CCK-8 solution) , placed in an incubator and in...

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Abstract

The invention discloses a tin selenide nano material, a preparation method and application thereof. Tin selenide is synthesized by utilizing a simple, mild and green method, further, hydrophilic ligands are modified in an ultrasonic method and tin selenide nano-sheets with good water dispersibility are synthesized. The nano material has strong near-infrared absorption property and is capable of converting effective near-infrared laser into thermal energy; the photo-thermal conversion efficiency is up to 29.8%; meanwhile, the nano material has good photo-thermal stability and can be applied to light-heat treatment for cancer cells. Meanwhile, the nano material has big specific surface area of a two-dimensional laminated structure and higher medicine-carrying capacity; the nano medicine complex is capable of realizing medicine release effects of pH value response and photo-thermal response and can be utilized as a medicine carrier for chemotherapy of cancer cells. The nano material can be applied to photoacoustic imaging and infrared thermal imaging and realizes photo-thermal and medicine integrated treatment of imaging guidance.

Description

technical field [0001] The invention belongs to the fields of nanomaterial preparation and biomedicine, and in particular relates to a tin selenide nanomaterial and its preparation method and application. Background technique [0002] In recent years, the application of nanomaterials in the field of biomedicine has attracted more and more attention from researchers, and has become an important direction for the development of nanotechnology. The introduction of nanomaterials into biomedicine may realize multiple functions in a single system at the same time, which is one of the important development trends in the field of nanomedicine. This kind of multifunctional nanomaterials integrates multiple purposes such as simultaneous imaging and treatment on a single nanomaterial, or integrates multiple components to achieve multiple target functions in order to achieve some advanced functions, which can reduce the side effects of multiple diagnosis and treatment. Better diagnosis...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01B19/04A61K47/04B82Y30/00
CPCY02P20/129
Inventor 杨黄浩张晓龙郑琤梁虹王丽萍
Owner FUZHOU UNIV
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