Preparation method and application of metal-polyphenol nano-particles

A nanoparticle and metal technology, applied in the field of nanoparticle preparation, can solve the problems of reduced photothermal treatment effect, weakened EPR effect, shortened cycle time, etc., and achieves the effects of good biodegradability, good absorption, and cheap raw materials

Active Publication Date: 2018-05-25
GUANGXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, a series of photothermal reagents have been studied, such as carbon-based materials, copper sulfide semiconductor materials, some organic compounds, etc. (Tian Q, Tang M, Sun Y, et al. Advanced Materials, 2011, 23(31): 3542 -3547.), however, due to the non-degradability of many nanomaterials, the long residual time in the body severely limits their clinical applications
Although the problem of long residence time in the body can be solved by synthesizing ultra-small nanoparticles, the ultra-small nanoparticles may lose certain "nano-scale advantages" and significantly shorten their circulation time in the blood. Excreted by the kidneys, the EPR effect is weakened, resulting in a significant decline in the photothermal treatment effect (Chen Y, Cheng L, Dong Z, et al. Angewandte Chemie, 2017.)

Method used

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  • Preparation method and application of metal-polyphenol nano-particles

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] A preparation method of metal-polyphenol nanoparticles, comprising the steps of:

[0022] 1) Weigh 2.5 g of tannic acid and dissolve in 70 mL of distilled water, and dissolve 0.1 g of ammonium metavanadate in 30 mL of distilled water, and stir them evenly for later use;

[0023] 2) Heat the ammonium metavanadate solution to 60°C and stir for 60 min to obtain a golden yellow solution, namely the vanadium oxide solution;

[0024] 3) After adding the vanadium oxide solution dropwise to the tannic acid solution, react at 60°C for 24 h to obtain a black solution;

[0025] 4) Dialyze the black solution obtained in the previous step, change the distilled water every 2-3 hours for the first 12 hours, and change the distilled water every 5-6 hours for the next 36 hours to obtain the final product.

[0026] 5) The storage temperature of the final product is 4°C.

Embodiment 2

[0028] A preparation method of metal-polyphenol nanoparticles, comprising the steps of:

[0029] 1) Weigh 2.5 g of tannic acid and dissolve in 70 mL of distilled water, and dissolve 0.1 g of ammonium metavanadate in 30 mL of distilled water, and stir them evenly for later use;

[0030] 2) Heat the ammonium metavanadate solution to 80°C and stir for 30 minutes to obtain a golden yellow solution, namely the vanadium oxide solution;

[0031] 3) After adding the vanadium oxide solution dropwise to the tannic acid solution, react at 80°C for 24 h to obtain a black solution;

[0032] 4) Dialyze the black solution obtained in the previous step, change the distilled water every 2-3 hours for the first 12 hours, and change the distilled water every 5-6 hours for the next 36 hours to obtain the final product.

[0033] 5) The storage temperature of the final product is 4°C.

Embodiment 3

[0035] A preparation method of metal-polyphenol nanoparticles, comprising the steps of:

[0036] 1) Weigh 2.5 g of tannic acid and dissolve in 70 mL of distilled water, and dissolve 0.1 g of ammonium metavanadate in 30 mL of distilled water, and stir them evenly for later use;

[0037] 2) Heat the ammonium metavanadate solution to 100°C and stir for 10 minutes to obtain a golden yellow solution, namely the vanadium oxide solution;

[0038] 3) After adding the vanadium oxide solution to the tannic acid solution dropwise, react at 100°C for 24 h to obtain a black solution;

[0039] 4) Dialyze the black solution obtained in the previous step, change the distilled water every 2-3 hours for the first 12 hours, and change the distilled water every 5-6 hours for the next 36 hours to obtain the final product.

[0040] 5) The storage temperature of the final product is 4°C.

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Abstract

The invention discloses a preparation method and application of metal-polyphenol nano-particles. The preparation method comprises the following steps: weighing a certain amount of tannic acid and a certain amount of ammonium metavanadate, separately dissolving the tannic acid and the ammonium metavanadate into distilled water, and uniformly stirring for subsequent use; heating an ammonium metavanadate solution, and stirring to obtain a golden yellow solution, namely a vanadium oxide solution; adding the vanadium oxide solution in a tannic acid solution, and heating and reacting to obtain a black solution; and carrying out dialysis to obtain the final product. The product has biodegradability, and the preparation method is a novel method for preparing the metal-polyphenol nano-particles forphotothermal therapy. The preparation method is simple and convenient to operate, and the raw materials are cheap and easily obtained. The metal-polyphenol nano-particles prepared by the method not only can be absorbed well in a near-infrared region like a traditional photothermal reagent and can be used for photothermal therapy of cancers, but also particularly has biodegradability, facilitatesinternal excretion, is not residual in a living body, and has wide application prospect.

Description

technical field [0001] The invention relates to a preparation method and application of nanoparticles, in particular to a preparation method and application of biodegradable metal-polyphenol nanoparticles. Background technique [0002] Tannic acid, also known as tannic acid and tannin, is also known as tannic acid and tannin in the Pharmacopoeia. Anti-oxidant, anti-bacterial, anti-viral, anti-tumor and anti-cancer effects, strong binding ability with protein, active reaction with alkaloids, enzymes, metal ions, etc., and strong surface activity , has a direct biological effect on some injuries and diseases of the human body. When tannic acid coordinates with metal ions, two adjacent phenolic hydroxyl groups in tannic acid can form stable five-membered ring chelates with metal ions in the form of oxygen anions, although the third phenolic hydroxyl group does not participate in complexation , but can promote the dissociation of the other two phenolic hydroxyl groups, thereby...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61P35/00A61K47/26A61K47/02B82Y5/00
CPCA61K41/0052A61K47/02A61K47/26B82Y5/00
Inventor 蒋邦平陈婷沈星灿周波孙婉莹
Owner GUANGXI NORMAL UNIV
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