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Multifunctional nano-hybrid compound integrating CT imaging and phototherapy and its preparation method

A nano-hybrid, CT imaging technology, applied in the field of medicine, can solve the problems such as the preparation method and application of multi-functional nano-hybrid, and achieve good photothermal stability, good water solubility, and easy-to-obtain raw materials

Active Publication Date: 2019-10-15
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are no reports on multifunctional nano-hybrids, preparation methods and uses integrating CT imaging and phototherapy.

Method used

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  • Multifunctional nano-hybrid compound integrating CT imaging and phototherapy and its preparation method
  • Multifunctional nano-hybrid compound integrating CT imaging and phototherapy and its preparation method
  • Multifunctional nano-hybrid compound integrating CT imaging and phototherapy and its preparation method

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Embodiment 1

[0033] A method for preparing a multifunctional nano-hybrid compound integrating CT imaging and phototherapy, comprising the following steps:

[0034] (1) Preparation of molybdenum disulfide nanoplates modified with mercapto polyethylene glycol:

[0035] Add 90mg of molybdenum disulfide powder to 100mL of nitrogen methyl pyrrolidone, ultrasonically disperse at 20kHz for 6 hours; let stand for 4 hours, take 60mL of supernatant and centrifuge at 1000rpm for 10 minutes; add 10mL of ethyl acetate to precipitate out the precipitate , filtered, and the obtained solid is a molybdenum disulfide nanoplate; the molybdenum disulfide nanoplate and 8 mg of mercaptopolyethylene glycol 2000 are put into 3 mL of water, and stirred for 10 hours to obtain a molybdenum disulfide nanoplate modified with mercaptopolyethylene glycol water dispersion;

[0036] (2) Preparation of gold nanoparticles modified by 2-mercaptopyridine:

[0037]Add 120 μL of 10M chloroauric acid aqueous solution to a cont...

Embodiment 2

[0041] A method for preparing a multifunctional nano-hybrid compound integrating CT imaging and phototherapy, comprising the following steps:

[0042] (1) Preparation of molybdenum disulfide nanosheets (MoS) modified with mercapto polyethylene glycol 2 ):

[0043] Proportionally, add 100mg of molybdenum disulfide powder into 100mL of nitrogen methyl pyrrolidone, and disperse ultrasonically for 4 hours at a power of 30kHz; let stand for 5 hours, take 70mL of the supernatant and centrifuge at 2000rpm for 8 minutes; add 13mL of ethyl acetate The ester precipitates and precipitates, filtered, and the resulting solid is molybdenum disulfide nanoplate; put the molybdenum disulfide nanoplate and 9mg mercaptopolyethylene glycol 2000 into 4mL water, stir for 11 hours, and obtain mercaptopolyethylene glycol modified disulfide Aqueous dispersion of molybdenum nanoplate;

[0044] (2) Preparation of 2-mercaptopyridine modified gold nanoparticles (AuNPs):

[0045] Add 125 μL of 10M chlor...

Embodiment 3

[0049] A method for preparing a multifunctional nano-hybrid compound integrating CT imaging and phototherapy, comprising the following steps:

[0050] (1) Preparation of molybdenum disulfide nanoplates modified with mercapto polyethylene glycol:

[0051] According to the proportion, add 110mg molybdenum disulfide powder into 100mL nitrogen methyl pyrrolidone, disperse ultrasonically for 3 hours under the condition of power of 40kHz; let stand for 6 hours, take 80mL supernatant and centrifuge at 3000rpm for 5 minutes; add 15mL ethyl acetate The ester precipitates and precipitates, is filtered, and the obtained solid is a molybdenum disulfide nanoplate; the molybdenum disulfide nanoplate and 10 mg mercaptopolyethylene glycol 2000 are put into 5 mL of water, and stirred for 12 hours to obtain a mercaptopolyethylene glycol modified disulfide Aqueous dispersion of molybdenum nanoplate;

[0052] (2) Preparation of gold nanoparticles modified by 2-mercaptopyridine:

[0053] Add 130...

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Abstract

The invention discloses a multifunctional nanometer hybrid integrated CT imaging and phototherapy and a preparing method. The nanometer hybrid is shown through MoS2-AuNPs-Ce6, wherein MoS2 is the abbreviation of a molybdenum disulfide nano-plate modified by thiol-polyethylene glycol, AuNPs is the abbreviation of gold nano-particles modified by 2-mercaptopyridine, and Ce6 is the abbreviation of chlorine e6. The preparing technology of the nanometer hybrid MoS2-AuNPs-Ce6 is simple, reaction controllability is high, energy consumption is low, large scale is easy to achieve, raw materials for use are easy to obtain, and the price is low; the nanometer hybrid can be used for CT imaging; good water solubility and good biocompatibility are shown, high near infrared absorption and good photo-thermal stability are achieved, and the hybrid can be used for photo-thermal treatment and infrared thermal imaging at the same time; and a strong photodynamic therapy function is achieved, and an inhibiting function is achieved on tumor cells.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a nano-hybrid compound integrating CT imaging and phototherapy, a preparation method and an application. Background technique [0002] Photothermal therapy is a minimally invasive tumor treatment technology developed in recent years. It mainly uses near-infrared light to directly irradiate the tumor site with light-absorbing photothermal therapeutic agent to increase the local temperature to kill the tumor. cells, greatly reducing systemic toxicity, so photothermal therapy is seen as one of the very potential alternative techniques for surgical treatment of tumors. Since water and proteins in biological tissues have weak absorption of near-infrared light, an ideal photothermal therapeutic agent should have strong absorption in the near-infrared light region (650-950nm). [0003] For tumor treatment, there are many limitations in single treatment methods. In order to achieve b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K41/04A61P35/00
Inventor 李楠刘丽王金平谭潇潇庞晓娟游青孙琪
Owner TIANJIN UNIV
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