Molybdenum disulfide nano-dot/polyaniline nano-hybrid compound and its preparation method and application

A nano-hybrid, molybdenum disulfide technology, applied in the field of medicine, can solve the problem of not finding nano-hybrid, etc., and achieve the effects of good photothermal stability, strong near-infrared absorption, and easy scale.

Active Publication Date: 2019-12-13
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no reports on the preparation of this nano-hybrid and its use in CT imaging and photothermal therapy.

Method used

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  • Molybdenum disulfide nano-dot/polyaniline nano-hybrid compound and its preparation method and application
  • Molybdenum disulfide nano-dot/polyaniline nano-hybrid compound and its preparation method and application
  • Molybdenum disulfide nano-dot/polyaniline nano-hybrid compound and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The preparation method of molybdenum disulfide nano-dot / polyaniline nano-hybrid compound comprises the following steps:

[0032] (1) Add 1 g of molybdenum disulfide powder to 100 ml of nitrogen methyl pyrrolidone, ultrasonically disperse at 250W for 4 hours; let stand for 4 hours, take the supernatant and stir it at 140°C for 6 hours; centrifuge at 3000rpm for 5 Minutes; Get the supernatant and evaporate under reduced pressure at 75°C to remove nitrogen methylpyrrolidone, add 13 milliliters of ethyl acetate to separate out a yellow precipitate, filter, and dry to obtain yellow molybdenum disulfide nano-dot powder; (molybdenum disulfide nano-dot MoS for short 2 QDs)

[0033] (2) Get 30 milliliters of 20mM aniline aqueous solution and 6 milliliters of 400mM sodium lauryl sulfate aqueous solution and mix uniformly to obtain a mixed solvent; 0.01 gram of molybdenum disulfide nano-dot powder and 0.1 gram of polyvinylpyrrolidone are added to the mixed solvent, stirred for 3...

Embodiment 2

[0037] The preparation method of molybdenum disulfide nano-dot / polyaniline nano-hybrid compound comprises the following steps:

[0038](1) Add 1 g of molybdenum disulfide powder to 150 ml of nitrogen-methylpyrrolidone, disperse ultrasonically at 400W for 5 hours; let stand for 5 hours, take the supernatant and stir it at 130°C for 8 hours; centrifuge at 2000rpm for 10 Minutes; take the supernatant and evaporate under reduced pressure at 70°C to remove nitrogen methyl pyrrolidone, add 10 ml of ethyl acetate to precipitate a yellow precipitate, filter, and dry to obtain yellow molybdenum disulfide nano-dot powder;

[0039] (2) Get 30 milliliters of 10mM aniline aqueous solution and 6 milliliters of 300mM sodium lauryl sulfate aqueous solution and mix uniformly to obtain a mixed solvent; 0.01 gram of molybdenum disulfide nano-dot powder and 0.15 gram of polyvinyl pyrrolidone are added to the mixed solvent, stirred for 2 hours;

[0040] (3) Add 20 milliliters of 20mM ammonium per...

Embodiment 3

[0043] The preparation method of molybdenum disulfide nano-dot / polyaniline nano-hybrid compound comprises the following steps:

[0044] (1) Add 1 g of molybdenum disulfide powder to 200 ml of nitrogen-methylpyrrolidone, ultrasonically disperse at 500 W for 3 hours; let it stand for 2 hours, take the supernatant and stir it at 150 ° C for 6 hours; centrifuge at 4000 rpm for 5 Minutes; take the supernatant and evaporate under reduced pressure at 80°C to remove nitrogen-methylpyrrolidone, add 15 ml of ethyl acetate to precipitate a yellow precipitate, filter, and dry to obtain yellow molybdenum disulfide nano-dot powder;

[0045] (2) Get 30 milliliters of 30mM aniline aqueous solution and 6 milliliters of 500mM sodium lauryl sulfate aqueous solution and mix uniformly to obtain a mixed solvent; 0.01 gram of molybdenum disulfide nano-dot powder and 0.2 gram of polyvinylpyrrolidone are added to the mixed solvent, stirred for 4 hours;

[0046] (3) Add 20 milliliters of 40mM ammonium...

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Abstract

The invention discloses a molybdenum disulfide nanodot and polyaniline nanohybrid and a preparation method and application. The preparation method comprises the steps that 1, molybdenum disulfide nanodot powder is prepared; 2, an aqueous solution of aniline and an aqueous solution of sodium dodecyl sulfate are taken and mixed to be uniform, a mixed solvent is obtained, and the molybdenum disulfide nanodot powder and povidone are added into the mixed solvent to be stirred; 3, an ammonium persulfate solution is dropwise added into liquid obtained in the second step, stirring and centrifuging are conducted, green precipitate is obtained, freeze drying is conducted, and the molybdenum disulfide nanodot and polyaniline nanohybrid is obtained. The molybdenum disulfide nanodot and polyaniline nanohybrid has water solubility and biocompatibility, can encapsulate a large quantity of molybdenum disulfide nanodots, can be used for CT imaging, displays good and high near infrared absorption and good light and thermal stability and can be used for light and thermal treatment and infrared thermal imaging simultaneously. The preparation method is simple, the reaction condition is mild, the controllability is high, energy consumption is low, large scale is easy to achieve, and the cost is low.

Description

technical field [0001] The invention relates to a molybdenum disulfide nano-dot / polyaniline nano-hybrid, a preparation method and an application thereof, and belongs to the field of medicine. Background technique [0002] Photothermal therapy is a minimally invasive tumor treatment technology developed in recent years. It mainly kills tumor cells by directly irradiating light energy to the tumor site to increase its local temperature, which greatly reduces systemic toxicity. Therapy is regarded as one of the techniques for treating tumors that has great potential to replace surgery. To improve the efficiency and tumor selectivity of laser-induced photothermal therapy, photothermal therapeutic agents with light-absorbing properties are usually introduced into tumor sites. Since water and protein in biological tissues absorb near-infrared light relatively weakly, so near-infrared light has the best penetrability to tissue, an ideal photothermal therapeutic agent should have a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/00A61K49/04A61K41/00A61P35/00
CPCA61K41/0052A61K49/0013A61K49/0093A61K49/04
Inventor 李楠王金平谭潇潇庞晓娟刘丽谭丰苹
Owner TIANJIN UNIV
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